ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 999 • 2012 ACR/ARHP Annual Meeting

    Identification of New Epistatic Interactions with the HLA Region in the Genetic Etiology of Psoriasis and Psoriatic Arthritis

    Sara Marsal1, Juan D. Cañete2, Jose Luis Fernandez-Sueiro3, Raimon Sanmarti2, Jesus Rodriguez Moreno4, Jordi Gratacós5, Rubén Queiro6, Carlos Montilla7, Juan Carlos Torre-Alonso8, Jose Perez Venegas9, Santiago Muñoz-Fernández10, Carlos M. Gonzalez11, Daniel Roig12, Alba Erra13, Isabel Acosta1, Antonio Fernández-Nebro14, Pedro Zarco15, Arnald Alonso16, María América López-Lasanta16, Raül Tortosa16 and Antonio Julià16, 1Rheumatology Service, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 2Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, 3Rheumatology Service, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, 4Rheumatology Service, Hospital Universitario de Bellvitge., Barcelona, Spain, 5Rheumatology Service, Hospital Universitari Parc Taulí, Sabadell (Barcelona), Spain, 6Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain, 7Rheumatology Service, Hospital Universitario de Salamanca, Salamanca, Spain, 8H. Monte Naranco, Oviedo, Spain, 9Rheumatology Service, Hospital del SAS de Jerez de la Frontera, Jerez De La Frontera, Spain, 10Unit Rheumatology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes (Madrid), Spain, 11Rheumatology, Hospital Gregorio Maranon, Madrid, Spain, 12Rheumatology Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat- Barcelona, Spain, 13Rheumatology Service, Hospital San Rafael, Barcelona, Spain, 14Rheumatology Service, Hospital Regional Universitario Carlos Haya, Málaga, Spain, 15Rheumatology Service, Fundación Hospital Alcorcon, Alcorcon, Madrid, Spain, 16Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain

    Background/Purpose: Psoriatic Arthritis (PsA) is a complex disease and is present in ~11% in patients with Psoriasis (Ps). Recently, Genomewide Association Studies (GWAS) have expanded…
  • Abstract Number: 2548 • 2012 ACR/ARHP Annual Meeting

    Global Molecular Effects of Tocilizumab Therapy in Synovial Biopsies of Early Rheumatoid Arthritis Patients

    Julie Ducreux1, Adrien Nzeusseu Toukap2, Frédéric A. Houssiau1, Patrick Durez3 and Bernard Lauwerys3, 1Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, 2Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 3Department of Rheumatology, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we…
  • Abstract Number: 976 • 2012 ACR/ARHP Annual Meeting

    Effect of Interactions Between Validated Rheumatoid Arthritis Genetic Factors and Environmental Factors On Rheumatoid Arthritis Risk

    Chia-Yen Chen1, Linda T. Hiraki2, Susan Malspeis3, Jing Cui4, Bing Lu4, Robert M. Plenge5, Karen H. Costenbader4 and Elizabeth W. Karlson6, 1Department of Epidemiology, Harvard School of Public Health, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 3Rheumatology, Brigham and Women's Hospital, Boston, MA, 4Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose:  Studies have shown associations between environmental factors and rheumatoid arthritis (RA) risk. Also, genome-wide association studies (GWAS) have identified genetic markers associated with RA…
  • Abstract Number: 2671 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Association Study Establishes Muliple Susceptibility Loci for Sjögren’s Syndrome

    Christopher J. Lessard1, He Li2, Indra Adrianto3, John A. Ice3, Roland Jonsson4, Gabor G. Illei5, Maureen Rischmueller6, Gunnel Nordmark7, Xavier Mariette8, Corinne Miceli-Richard9, Marie Wahren-Herlenius10, Torsten Witte11, Michael T. Brennan12, Roald Omdal13, Patrick M. Gaffney3, James A. Lessard14, Wan-Fai Ng15, Nelson L. Rhodus16, Barbara M. Segal17, R. Hal Scofield18, Judith A. James19, Juan-Manuel Anaya20, John B. Harley21, Courtney G. Montgomery3 and Kathy Moser Sivils19, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway, 5Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, 6Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, 7Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 8Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, 9Hopital Bicêtre, Le Kremlin Bicêtre, France, 10Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 11Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 12Nidcr NIH, Carolinas Medical Center, Charlotte, NC, 13Department of Internal Medicine, Stavanger university Hospital, Stavanger, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, 14Valley Bone and Joint Clinic, Grand Forks, ND, 15Musculoskeletal Research Group Institute of Cellular Medicine, Newcastle University, Newcastle University, Newcastle, England, 16University of Minnesota, Minneapolis, MN, 17Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Oklahoma Medical Research Foundation, Oklahoma City, OK, 20School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 21Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. A…
  • Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting

    Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study

    Lara Bossini-Castillo1, Jose Ezequiel Martin2, Carmen Pilar Simeon3, Lorenzo Beretta4, Olga Y. Gorlova5, Madelon C. Vonk6, Patricia Carreira7, the Spanish Scleroderma Group8, Annemie Schuerwegh9, Alexandre Voskuyl10, Anna-Maria Hoffmann-Vold11, Roger Hesselstrand12, Annika Nordin13, Claudio Lunardi14, Jaap Van Laar15, Paul Shiels16, Ariane Herrick17, Jane Worthington18, Carmen Fonseca19, Christopher P. Denton19, Shervin Assassi20, Bobby P.C. Koeleman21, Maureen D. Mayes22, T.R.D.J. Radstake23 and Javier Martin1, 1Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 2Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 3Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, 4Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 5Department of Epidemiology, UT M. D. Anderson Cancer Center, Houston, TX, 6Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 7Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 8Granada, Spain, 9Leids Univ Medisch Centrum, Leiden, Netherlands, 10Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 11Rheumatology, Oslo University Hospital, Oslo, Norway, 12Rheumatology, Lund University, Lund, Sweden, 13Department of Rheumatology, Karolinska Institute, Stockholm, Sweden, 14Department of Medicine, Università degli Studi di Verona, Verona, Italy, 15Rheumatology, Leiden University Hospital, Leiden, Netherlands, 16University of Glasgow, Glasgow, United Kingdom, 17Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, 18Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 19Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 20Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 21Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 22Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 23Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…
  • Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Xia Jiang1, Henrik Källberg1, Leonid Padyukov2, Lars Klareskog3 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
  • Abstract Number: 2654 • 2012 ACR/ARHP Annual Meeting

    Genome-Wide Association Study of Methotrexate Response Identifies Novel Genes in a Large Cohort of European Juvenile Idiopathic Arthritis Cases

    Joanna Cobb1, Erika Cule2, Halima Moncrieffe3, Edward Flynn4, Anne Hinks1, Fiona Patrick3, Laura Kassoumeri3, Simona Ursu5, Maja Bulatovic6, Marek Bohm7, Bertrand D. van Zelst8, Pavla Dolezalova9, Robert De Jonge8, Nico M. Wulffraat6, Stanton Newman10, Maria de Iorio11, Lucy R. Wedderburn3 and Wendy Thomson1, 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 2Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom, 3Institute of Child Health, University College London, London, United Kingdom, 4Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, 5Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, 6Paediatric Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, 7First Faculty of Medicine and General Faculty Hospital, Prague, Czech Republic, 8Clinical Chemistry, Erasmus Medical Center, Rotterdam, Netherlands, 9Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, 10School of Community & Health Sciences, City University London, London, United Kingdom, 11Department of Statistical Sciences, University College London, London, United Kingdom

    Background/Purpose: The drug methotrexate (MTX) is the first line treatment for many children with Juvenile Idiopathic Arthritis (JIA). Only 45% of children treated with MTX…
  • Abstract Number: 2304 • 2012 ACR/ARHP Annual Meeting

    Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes

    F. David Carmona1, M.C. Cénit1, L.M. Díaz-Gallo1, Carmen P. Simeón2, Patricia Carreira3, the Spanish Scleroderma Group4, Nicolas Hunzelmann5, Gabriela Riemekasten6, Torsten Witte7, Alexander Kreuter8, Jörg HW Distler9, Paul Shiels10, Jacob M. van Laar11, Annemie Schuerwegh12, Madelon C. Vonk13, Alexandre Voskuyl14, Carmen Fonseca15, Christopher Denton16, Ariane Herrick17, Frank C. Arnett18, Filemon K. Tan18, Shervin Assassi18, T.R.D.J. Radstake19, Maureen D. Mayes18 and Javier Martin1, 1Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, 2Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, 3Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 4Granada, Spain, 5Department of Dermatology, University of Cologne, Cologne, Germany, 6Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 7Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 8Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, 9Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 10University of Glasgow, Glasgow, United Kingdom, 11Newcastle University, Musculoskeletal Research Group, Newcastle, United Kingdom, 12Leids Univ Medisch Centrum, Leiden, Netherlands, 13Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 14Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 15Department of Rheumatology, Royal Free Hospital, London, United Kingdom, 16Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, 17Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, 18Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 19Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Systemic sclerosis (SSc) is a fibrotic autoimmune disease that represents a clear example of a sex biased immune disorder. The X-chromosome gene IRAK1 has…
  • Abstract Number: 980 • 2012 ACR/ARHP Annual Meeting

    Genomewide Association Study in Systemic Lupus Erythematosus: Known Loci

    Antonio Fernandez-Nebro1, Patricia E. Carreira2, Ricardo Blanco3, Victor M. Martinez-Taboada4, Luis Carreño5, Alejandro Olive6, José Luis Andreu7, Mª Angeles Aguirre8, Paloma Vela9, Jose Javier Pérez Venegas10, Jose Luís Marenco11, Joan Miquel Nolla12, Antonio Zea13, José M. Pego-Reigosa14, Mercedes Freire González15, Gabriela Ávila16, María América López-Lasanta16, Raül Tortosa16, Antonio Julià16 and Sara Marsal16, 1Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, 2Rheumatology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, 3Rheumatology, Hospital Universitario Marques De Valdecilla, Santander, Spain, 4Rheumatology, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain, 5Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, 6Rheumatology Service, Germans Trias Pujol Hospital, Barcelona, Spain, 7Rheumatology, Puerta de Hierro Universitary Hospital, Madrid, Spain, 8Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 9Rheumatology, Hospital General Universitario de Alicante, Alicante, Spain, 10Rheumatology, Hospital del SAS de Jerez de la Frontera, Jerez De La Frontera, Spain, 11Rheumatology, HU Puerta de Hierro Majadahonda, Madrid, Spain, 12Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 13Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, 14Rheumatology, Hospital do Meixoeiro, Vigo, Spain, 15Rheumatology, Complejo Hospitalario Universitario de La Coruña,, La Coruña, Spain, 16Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with an estimated prevalence of 40:100,000 cases in European populations. SLE has a strong genetic…
  • Abstract Number: 2657 • 2012 ACR/ARHP Annual Meeting

    Genome-Wide Association Meta-Analysis of Eight Independent Systemic Juvenile Idiopathic Arthritis Collections Reveals Regional Association Spanning the Major Histocompatibility Complex Class II and III Gene Cluster

    Michael J. Ombrello1, Elaine Remmers2, Alexei A. Grom3, Wendy Thomson4, Alberto Martini5, Marco Gattorno6, Seza Ozen7, Sampath Prahalad8, John F. Bohnsack9, Andrew Zeft10, Norman T. Ilowite11, Elizabeth D. Mellins12, Ricardo A. G. Russo13, Claudio Len14, Sheila K. Oliveira15, Rae SM Yeung16, Lucy R. Wedderburn17, Jordi Anton Lopez18, Colleen Satorius19, Ioanna Tachmazidou20, Carl D. Langefeld21, Eleftheria Zeggini20, Susan D. Thompson22, Patricia Woo23 and Daniel L. Kastner2, 1Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 3PRCSG, Cincinnati, OH, 4Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, Manchester, United Kingdom, 5Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, 6Second Division of Paediatrics, Istituto Giannina Gaslini, Genova, Italy, 7Hacettepe University, Ankara, Turkey, 8Pediatrics, Emory Children's Center, Atlanta, GA, 9Dept of Pediatriacs, University of Utah, Salt Lake City, UT, 10Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, 11Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, 12Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA, 13Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, 14Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, 15Pediatric Rheumatology, Instituto de Pediatria e Puericultura Martagão Gesteira (IPPMG) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, 16Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 17Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, 18pediatric Rheumatology, University Childrenxs Hospital, Barcelona, Spain, 19Inflammatory Disease Section, National Human Genome Research Institute, Nationsl Institutes of Health, Bethesda, MD, 20The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 21Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 22Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 23Division of Infection and Immunity, University College London, London, United Kingdom

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare inflammatory disease that is inherited as a complex genetic trait.  While the pathophysiology of sJIA is…
  • Abstract Number: 2284 • 2012 ACR/ARHP Annual Meeting

    Epigenetic Profiling in Monozygotic Twins Discordant for Systemic Lupus Erythematosus Reveals Prominent Hypomethylation of Interferon-Inducible Genes

    Paula S. Ramos1, Timothy D. Howard2, Miranda C. Marion3, Satria Sajuthi4, Jennifer A. Kelly5, Kathy L. Moser5 and Carl D. Langefeld4, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 4Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 5Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease. In addition to genetic and environmental influences, the discordance rate between monozygotic (MZ)…
  • Abstract Number: 982 • 2012 ACR/ARHP Annual Meeting

    Genetic Variants near Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) Are Associated with Hip Osteoarthritis

    Daniel S. Evans1, Neeta Parimi1, Ana M. Valdes2, Hanneke J.M Kerkhof3, Frederic Cailotto4, Michael C. Nevitt5, Steven R. Cummings1, Rik J. Lories6, Timothy D. Spector7, Nigel K. Arden8, Joyce B. van Meurs3 and Nancy E. Lane9, 1California Pacific Medical Center Research Institute, San Francisco, CA, 2Department of Twin Research and Genetic Epidemiology, Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, 3Department of Internal Medicine, Erasmus Medical Center and The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands, 4Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, 5Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 6Dept of Development and Regeneration, Laboratory for Skeletal Development and Joint Disorders, KU Leuven, Leuven, Belgium, 7Dept of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, 8NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 9Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA

    Background/Purpose: Hip osteoarthritis (HOA) is one of the most common joint disorders and can result in pain and disability.  HOA is heritable, but the particular…
  • Abstract Number: 2663 • 2012 ACR/ARHP Annual Meeting

    A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results From a Candidate Gene Study

    Cecilia P. Chung1, Joseph F. Solus2, Annette M. Oeser3, Chun Li4, Paolo Raggi5, Jeffrey R. Smith3 and C. Michael Stein3, 1Medicine, Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt Medical Center, Nashville, TN, 3Vanderbilt University, Nashville, TN, 4Biostatistics, Vanderbilt University, Nashville, TN, 5Emory University, Atlanta, GA

    Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. However, this association is not fully explained by traditional cardiovascular risk factors or markers of inflammation. Little is…
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