Abstracts tagged "genomics"

Abstract Number: 1136 • 2014 ACR/ARHP Annual Meeting
Transcriptional Heterogeneity of the SLC2A9 Gene Encoding the GLUT9 Urate Transporter
David B. Mount^1,2, Tony R. Merriman³, Eli A. Stahl⁴, Hyon K. Choi⁵ and Asim Mandal¹, ¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Renal Division, VA Boston Healthcare System, Boston, MA, ³Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Variation in SLC2A9, which encodes the urate transporter GLUT9, is the major single genetic determinant of serum uric acid (SUA); however, the causal variant(s)…
Abstract Number: 782 • 2014 ACR/ARHP Annual Meeting
Temporal Artery Microbiome in Giant Cell Arteritis
Alison Clifford*¹, Pauline Funchain*^2,3,4, Lisa Lystad⁵, Charissa Peterson⁴, Jessica Altemus⁴, Gary S. Hoffman¹ and Charis Eng^2,3,4,6, ¹Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ²Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, ³Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, ⁴Genomic Medicine Institute, Lerner Research Institute, Cleveland, OH, ⁵Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁶Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
Background/Purpose: Whether infectious agents play a part in giant cell arteritis (GCA) remains controversial. We have performed the first microbiome study of snap-frozen temporal arteries,…
Abstract Number: 772 • 2014 ACR/ARHP Annual Meeting
RNA-Seq and Mir-Seq Analysis of SSc Skin Across Intrinsic Gene Expression Subsets Shows Differential Expression of Non-Coding RNAs Regulating SSc Gene Expression
Zhenghui Li¹, Eleni Marmarelis², Kun Qu³, Lionel Brooks⁴, Patricia Pioli⁴, Howard Chang³, Robert Lafyatis⁵ and Michael Whitfield⁴, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease with a heterogenous and complex phenotype. Previously, our lab has identified four gene expression subsets (fibroproliferative,…
Abstract Number: 1883 • 2013 ACR/ARHP Annual Meeting
Fine Mapping and Expression Of a Locus Overlapping 3 Types Of Inflammatory Arthritis
Kathryn J. A Steel¹, Anne Hinks¹, Annie Yarwood², Stephen Eyre³, Edward Flynn³, Paul Martin¹, Anne Barton^3,4 and Wendy Thomson^1,5, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In a recent fine-mapping study using the Immunochip array, the RUNX1 region was strongly associated with rheumatoid arthritis (RA p=5x10-10), juvenile idiopathic arthritis (JIA…
Abstract Number: 1702 • 2013 ACR/ARHP Annual Meeting
Identification of Multiple Genetic Susceptibility Loci in Takayasu’s Arteritis
Guher Saruhan-Direskeneli¹, Travis Hughes², Patrick S. Coit², Joel M. Guthridge³, Judith A. James⁴, Peter A. Merkel of behalf of the Vasculitis Clinical Research Consortium⁵, Haner Direskeneli on behalf of the Turkish Takayasu Study Group⁶ and Amr H. Sawalha², ¹Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Takayasu’s arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu’s arteritis remains poorly understood, but genetic contribution to the disease…
Abstract Number: 1633 • 2013 ACR/ARHP Annual Meeting
Sub-Phenotype Mapping In Systemic Lupus Erythematosus Identifies Multiple Novel Loci Associated With Circulating Interferon Alpha
Silvia Kariuki¹, Yogita Ghodke², Jessica M. Dorschner², Beverly Chrabot³, Jennifer A. Kelly⁴, Betty P. Tsao⁵, Robert P. Kimberly⁶, Marta E. Alarcon-Riquelme⁷, Chaim O. Jacob⁸, Lindsey A. Criswell⁹, Kathy L. Sivils¹⁰, Carl D. Langefeld¹¹, John B. Harley¹², Andrew D. Skol¹ and Timothy B. Niewold², ¹Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ⁶Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁸Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁹Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ¹⁰Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ¹²Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a phenotypically heterogeneous complex disease. Our previous work has documented significant genetic heterogeneity, with some well-validated risk factors demonstrating…
Abstract Number: 1634 • 2013 ACR/ARHP Annual Meeting
Genome-Wide Transcriptional Profiling Of Isolated Immune Cell Populations From SLE Patients With Different Ancestral Backgrounds
Shruti Sharma¹, Zhongbo Jin², Elizabeth Rosenzweig³, Swapna Rao⁴, Kichul Ko⁴ and Timothy B. Niewold², ¹Gwen Knapp Center for Lupus Research, University of Chicago, Chicago, IL, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ⁴Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease of uncertain etiology. Different ancestral backgrounds demonstrate different clinical manifestations and autoantibody profiles. Whole…
Abstract Number: 165 • 2013 ACR/ARHP Annual Meeting
New Insights Into The Metabolic Origin Of Osteoarthritis
Ignacio Rego-Pérez¹, María Eugenia Vázquez-Mosquera², Angel Soto-Hermida², Mercedes Fernández-Moreno², Juan Fernández-Tajes², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^3,4,5, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: Metabolic alterations take place in osteoarthritis (OA) and the mtDNA haplogorups influence the prevalence and severity of the disease. The aim of this work…
Abstract Number: 2548 • 2012 ACR/ARHP Annual Meeting
Global Molecular Effects of Tocilizumab Therapy in Synovial Biopsies of Early Rheumatoid Arthritis Patients
Julie Ducreux¹, Adrien Nzeusseu Toukap², Frédéric A. Houssiau¹, Patrick Durez³ and Bernard Lauwerys³, ¹Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Department of Rheumatology, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we…
Abstract Number: 976 • 2012 ACR/ARHP Annual Meeting
Effect of Interactions Between Validated Rheumatoid Arthritis Genetic Factors and Environmental Factors On Rheumatoid Arthritis Risk
Chia-Yen Chen¹, Linda T. Hiraki², Susan Malspeis³, Jing Cui⁴, Bing Lu⁴, Robert M. Plenge⁵, Karen H. Costenbader⁴ and Elizabeth W. Karlson⁶, ¹Department of Epidemiology, Harvard School of Public Health, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Studies have shown associations between environmental factors and rheumatoid arthritis (RA) risk. Also, genome-wide association studies (GWAS) have identified genetic markers associated with RA…
Abstract Number: 2671 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Establishes Muliple Susceptibility Loci for Sjögren’s Syndrome
Christopher J. Lessard¹, He Li², Indra Adrianto³, John A. Ice³, Roland Jonsson⁴, Gabor G. Illei⁵, Maureen Rischmueller⁶, Gunnel Nordmark⁷, Xavier Mariette⁸, Corinne Miceli-Richard⁹, Marie Wahren-Herlenius¹⁰, Torsten Witte¹¹, Michael T. Brennan¹², Roald Omdal¹³, Patrick M. Gaffney³, James A. Lessard¹⁴, Wan-Fai Ng¹⁵, Nelson L. Rhodus¹⁶, Barbara M. Segal¹⁷, R. Hal Scofield¹⁸, Judith A. James¹⁹, Juan-Manuel Anaya²⁰, John B. Harley²¹, Courtney G. Montgomery³ and Kathy Moser Sivils¹⁹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway, ⁵Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁶Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ⁷Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁸Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ⁹Hopital Bicêtre, Le Kremlin Bicêtre, France, ¹⁰Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹¹Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹²Nidcr NIH, Carolinas Medical Center, Charlotte, NC, ¹³Department of Internal Medicine, Stavanger university Hospital, Stavanger, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹⁴Valley Bone and Joint Clinic, Grand Forks, ND, ¹⁵Musculoskeletal Research Group Institute of Cellular Medicine, Newcastle University, Newcastle University, Newcastle, England, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁸Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁰School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ²¹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. A…
Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting
Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study
Lara Bossini-Castillo¹, Jose Ezequiel Martin², Carmen Pilar Simeon³, Lorenzo Beretta⁴, Olga Y. Gorlova⁵, Madelon C. Vonk⁶, Patricia Carreira⁷, the Spanish Scleroderma Group⁸, Annemie Schuerwegh⁹, Alexandre Voskuyl¹⁰, Anna-Maria Hoffmann-Vold¹¹, Roger Hesselstrand¹², Annika Nordin¹³, Claudio Lunardi¹⁴, Jaap Van Laar¹⁵, Paul Shiels¹⁶, Ariane Herrick¹⁷, Jane Worthington¹⁸, Carmen Fonseca¹⁹, Christopher P. Denton¹⁹, Shervin Assassi²⁰, Bobby P.C. Koeleman²¹, Maureen D. Mayes²², T.R.D.J. Radstake²³ and Javier Martin¹, ¹Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ²Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ³Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁴Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Department of Epidemiology, UT M. D. Anderson Cancer Center, Houston, TX, ⁶Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁷Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁸Granada, Spain, ⁹Leids Univ Medisch Centrum, Leiden, Netherlands, ¹⁰Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹¹Rheumatology, Oslo University Hospital, Oslo, Norway, ¹²Rheumatology, Lund University, Lund, Sweden, ¹³Department of Rheumatology, Karolinska Institute, Stockholm, Sweden, ¹⁴Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁵Rheumatology, Leiden University Hospital, Leiden, Netherlands, ¹⁶University of Glasgow, Glasgow, United Kingdom, ¹⁷Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ¹⁸Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ¹⁹Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²⁰Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ²²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…
Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Xia Jiang¹, Henrik Källberg¹, Leonid Padyukov², Lars Klareskog³ and Lars Alfredsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 2654 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Methotrexate Response Identifies Novel Genes in a Large Cohort of European Juvenile Idiopathic Arthritis Cases
Joanna Cobb¹, Erika Cule², Halima Moncrieffe³, Edward Flynn⁴, Anne Hinks¹, Fiona Patrick³, Laura Kassoumeri³, Simona Ursu⁵, Maja Bulatovic⁶, Marek Bohm⁷, Bertrand D. van Zelst⁸, Pavla Dolezalova⁹, Robert De Jonge⁸, Nico M. Wulffraat⁶, Stanton Newman¹⁰, Maria de Iorio¹¹, Lucy R. Wedderburn³ and Wendy Thomson¹, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom, ³Institute of Child Health, University College London, London, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁵Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Paediatric Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁷First Faculty of Medicine and General Faculty Hospital, Prague, Czech Republic, ⁸Clinical Chemistry, Erasmus Medical Center, Rotterdam, Netherlands, ⁹Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁰School of Community & Health Sciences, City University London, London, United Kingdom, ¹¹Department of Statistical Sciences, University College London, London, United Kingdom
Background/Purpose: The drug methotrexate (MTX) is the first line treatment for many children with Juvenile Idiopathic Arthritis (JIA). Only 45% of children treated with MTX…
Abstract Number: 2304 • 2012 ACR/ARHP Annual Meeting
Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes
F. David Carmona¹, M.C. Cénit¹, L.M. Díaz-Gallo¹, Carmen P. Simeón², Patricia Carreira³, the Spanish Scleroderma Group⁴, Nicolas Hunzelmann⁵, Gabriela Riemekasten⁶, Torsten Witte⁷, Alexander Kreuter⁸, Jörg HW Distler⁹, Paul Shiels¹⁰, Jacob M. van Laar¹¹, Annemie Schuerwegh¹², Madelon C. Vonk¹³, Alexandre Voskuyl¹⁴, Carmen Fonseca¹⁵, Christopher Denton¹⁶, Ariane Herrick¹⁷, Frank C. Arnett¹⁸, Filemon K. Tan¹⁸, Shervin Assassi¹⁸, T.R.D.J. Radstake¹⁹, Maureen D. Mayes¹⁸ and Javier Martin¹, ¹Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla (Granada), Spain, ²Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, ³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁴Granada, Spain, ⁵Department of Dermatology, University of Cologne, Cologne, Germany, ⁶Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ⁷Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ⁸Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ⁹Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰University of Glasgow, Glasgow, United Kingdom, ¹¹Newcastle University, Musculoskeletal Research Group, Newcastle, United Kingdom, ¹²Leids Univ Medisch Centrum, Leiden, Netherlands, ¹³Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁴Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹⁵Department of Rheumatology, Royal Free Hospital, London, United Kingdom, ¹⁶Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ¹⁷Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ¹⁸Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹⁹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Systemic sclerosis (SSc) is a fibrotic autoimmune disease that represents a clear example of a sex biased immune disorder. The X-chromosome gene IRAK1 has…

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