ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 0175 • ACR Convergence 2020

    Identifying Immuno-phenotypes in Juvenile Localized Scleroderma with RNA Sequencing

    Christina Schutt1, Emily Mirizio2, Kaila Schollaert-Fitch2, Claudia Salgado3, Miguel Reyes-Mugica3 and Kathryn Torok2, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh Medical Center, Pittsburgh

    Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue characterized by an early inflammatory infiltrate followed by fibrosis and…
  • Abstract Number: 1969 • ACR Convergence 2020

    The Dynamics of Macrophage Sub-Populations in the Inflammatory Phase Following Joint Trauma

    Samuel Hamilton1, Anna Montgomery1, Niamh Fahy2, Maximilian Mayr1, Shang-Yang Chen1, Gaurav Gadhvi1, Yvonne Bastiaansen-Jenniskens2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Erasmus MC, Rotterdam, Netherlands, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages fulfill critical functions in maintaining tissue homeostasis in steady-state, as well as in inflammation and immune response.  In the joint synovium, we have…
  • Abstract Number: 0471 • ACR Convergence 2020

    Splice Site Variants in IKBKG, Encoding NEMO, Detected by a Customized Analysis of Next-Generation Sequencing Data Cause an Early-onset Autoinflammatory Syndrome of Panniculitis and Cytopenias in Male and Female Patients

    Adriana de Jesus1, Sofia Torreggiani2, Bin Lin2, Jacob Mitchell2, Eric Karlins3, Andrew Oler3, Sara Alehashemi4, Dana Kahle5, Katelin R. Honer2, Gema Souto Adeva2, Eric Hanson6, Gina Montealegre Sanchez7, Amer Khojah8, Timothy Moran9, Eveline Wu9, Chris Scott10, Timothy Ronan Leahy11, Emma Jane MacDermott11, Orla Killeen12, Thaschawee Arkachaisri13, Zoran Gucev14, Kathryn Phillippi15, Vafa Mammadova16, Gulnara Nasrullayeva16 and Raphaela Goldbach-Mansky17, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 3Bioinformatics and Computational Biosciences Branch/NIAID/NIH, Bethesda, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Clarksville, MD, 5Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 6Indiana University School of Medicine, Indianapolis, IN, 7NIAID/NIH, Rockville, MD, 8Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 9UNC Chapel Hill, Chapel Hill, NC, 10University of Cape Town, Cape Town, South Africa, 11Our Lady's Children's Hospital, Dublin, Ireland, 12National Centre for Paediatric Rheumatology, CHI at Crumlin, Dublin, Ireland, 13Duke-NUS Medical School, Singapore, Singapore, 14University Children's Hospital, Medical Faculty Skopje, Skopje, Macedonia, 15Akron Children’s Hospital, Akron, OH, 16Azerbaijan Medical University, Baku, Azerbaijan, 17Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: The Inhibitor of Kappa-B Kinase Regulatory Subunit Gamma (IKBKG) is located on the X chromosome and encodes the NF-κB essential modulator (NEMO). Loss-of-function mutations…
  • Abstract Number: 0495 • ACR Convergence 2020

    Epstein Barr Virus (EBV), an Etiologic Factor for Systemic Lupus Erythematosus (SLE), Interacts with SLE Risk Loci Through EBV-encoded Transcription Co-factors (co-TFs)

    Viktoryia Laurynenka1, Xiaoting Chen1, Sreeja Parameswaran1, Shruti Eswar2, Kenneth Kaufman3, Bahram Namjou4, Matthew Weirauch5, Leah Kottyan4 and John Harley6, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, 3Cincinnati Children’s Hospital Medical Center;US Department of Veterans Affairs Medical Center, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, Cincinnati, OH, 5Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 6Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: SLE affects millions worldwide. The etiology of this complex autoimmune disease is the consequence of both strong genetic and environmental components. Genome-wide association studies…
  • Abstract Number: 0659 • ACR Convergence 2020

    Polynesian-Specific Gout-Associated Frameshift Variant in PRPSAP1

    Megan Leask1, Nicola Dalbeth2, Lisa Stamp3, Tony Merriman4, Amanda Phipps-Green4, Ruth Topless4, James Boocock5, Hyon Choi6, Keresoma Leaupepe1 and Eli Stahl7, 1University of Otago, Dunedin, Otago, New Zealand, 2University of Auckland, Auckland, New Zealand, 3University of Otago Christchurch, Christchurch, New Zealand, 4University of Otago, Dunedin, New Zealand, 5David Geffen School of Medicine at UCLA, Los Angeles, CA, 6Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA, 7Mt Sinai School of Medicine, New York, NY

    Background/Purpose: Polynesian (NZ Māori and Pacific) populations have increased prevalence of gout. Hyperuricaemia is contributed to by increased urate production in the liver via the…
  • Abstract Number: 0661 • ACR Convergence 2020

    Genomic Regions Jointly Associated with eGFR and Serum Urate: Implications for Shared Genetic Etiology of Hyperuricemia and Chronic Kidney Disease

    Nick Sumpter1, Alexa Lupi2, Megan Leask3, Tony Merriman4, Ana Vazquez2 and Richard Reynolds1, 1University of Alabama at Birmingham, Birmingham, AL, 2Michigan State University, East Lansing, MI, 3University of Otago, Dunedin, Otago, New Zealand, 4University of Otago, Dunedin, New Zealand

    Background/Purpose: Gout and hyperuricemia (HU), serum urate (SU) > 6.8 mg/dL, often present in the context of chronic kidney disease. It has long been known…
  • Abstract Number: 0700 • ACR Convergence 2020

    Lipoxin A4 Induces Lipid Class Switching and Inflammation Resolution at the Genomic Level in Human Osteoarthritis

    Mandar Dave1, Abul Islam2, Akshat Parekh3, Jay Patel4, Arushi Chawla5 and Ashok Amin6, 1Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, 2Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh, 3Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 4Northeast Ohio Medical University, Rootstown, OH, 5Gujarat Forensic Science University, Gujarat, India, 6Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, NY

    Background/Purpose: Human OA-affected cartilage does not show the cardinal signs of inflammation (redness and swelling with heat and pain—rubor et tumor cum calore et dolor) because…
  • Abstract Number: 0839 • ACR Convergence 2020

    Single-Cell Transcriptomics of Mouse and Human Lupus Nephritis Identifies Conserved Myeloid Populations Across Species

    Paul Hoover1, Michael Peters2, David Lieb3, Rakesh Mishra4, Nir Hacohen2 and Anne Davidson5, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4Feinstein Institute, Manhasset, NY, 5Northwell Health, New York

    Background/Purpose: We recently identified novel immune cell states in the kidneys of lupus nephritis patients (Arazi et al, Nature Immunology 2019). To determine the similarities…
  • Abstract Number: 007 • 2020 Pediatric Rheumatology Symposium

    Dense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel Susceptibility Locus for Systemic Juvenile Idiopathic Arthritis

    Emily Shuldiner 1, Elaine Remmers 2, Miranda Marion 3, Marc Sudman 4, Colleen Satorius 5, International Childhood Arthritis Genetics Consortium (INCHARGE), Juvenile Arthritis Consortium for the Immunochip (JACI), Wendy Thomson 6, Michael Ombrello1, Patricia Woo 7, Carl Langefeld 8, Sampath Prahalad 9 and Susan Thompson 10, 1NIAMS, NIH, Bethesda, 2National Human Genome Research Institute, Bethesda, 3Wake Forest University, Winston-Salem, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5NHGRI, NIH, Bethesda, 6Manchester Academic Health Science Centre, Manchester, United Kingdom, 7London, United Kingdom, 8Winston Salem, 9Emory + Children's Pediatric Institute, Atlanta, 10Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among childhood…
  • Abstract Number: 1018 • 2019 ACR/ARP Annual Meeting

    Renal Single Cell Genomics Links Type II Interferon and Lupus Nephritis in African-Americans

    Andrea Fava1, Yuji Zhang 2, Jill Buyon 3, Chaim Putterman 4, Nir Hacohen 5, Arnon Arazi 5, Celine Berthier 6, Deepak Rao 7, Michael Brenner 8, David Wofsy 9, Anne Davidson 10, Mathias Kretzler 11, David Hildeman 12, E. Steve Woodle 12, Betty Diamond 10, Thomas Tuschl 13, Evan Der 14, Hemant Suryawanshi 13, H. Michael Belmont 15, Peter Izmirly 16, Robert Clancy 16, The Accelerating Medicines Partnership 17 and Michelle Petri 18, 1Johns Hopkins University, Baltimore, 2University of Maryland, Baltimore, 3NYU School of Medicine, New York, 4Albert Einstein College of Medicine, New York, NY, 5Broad Institute, Cambridge, 6University of Michigan, Ann Arbor, MI, 7Brigham and Women's Hospital, Boston, MA, 8Brigham and Women’s Hospital:, Boston, 9UCSF, San Francisco, 10Feinstein Institutes for Medical Research, Manhasset, 11University of Michigan, Ann Arbor, 12University of Cincinnati, Cincinnati, 13Rockefeller Research Laboratories, New York, 14Albert Einstein College of Medicine, New York, 15New York University School of Medicine, Ney York, 16New York University School of Medicine, New York, 17Multiple Organizations, USA, 18Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Compared to Caucasian, African-American ethnicity is associated with a higher risk of developing systemic lupus erythematosus, lupus nephritis, high-risk histological features, resistance to treatment,…
  • Abstract Number: 1039 • 2019 ACR/ARP Annual Meeting

    Molecular Profiling Identifies Immunologic Subgroups and Informs Mechanism of Action of Baricitinib in SLE

    Thomas Dörner1, Yoshiya Tanaka 2, Michelle Petri 3, Josef Smolen 4, Daniel Wallace 5, Ernst Dow 6, Damiano Fantini 6, Richard Higgs 6, Guilherme Rocha 6, Brenda Crowe 6, Robert Benschop 6, Adam Abel 6, Nicole Byers 6, Maria Silk 6, Stephanie de Bono 6 and Robert Hoffman 6, 1Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Medical University of Vienna, Vienna, Austria, 5Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, 6Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Baricitinib is an oral selective Janus kinase (JAK) 1 and JAK2 inhibitor. In the Phase II, 24-week, randomized, placebo-controlled, double-blind study JAHH (NCT02708095), once-daily…
  • Abstract Number: 1041 • 2019 ACR/ARP Annual Meeting

    Computational Methods for Drug Repositioning of Systemic Sclerosis Using Gene Fold-Change and Network Analyses

    Dillon Popovich1, Michael Whitfield 2, Yue Wang 3, Guoshuai Cai 4 and Mengqi Huang 5, 1Geisel School of Medicine at Dartmouth College, Hanover, 2Geisel School of Medicine at Dartmouth College, Biomedical Data Science at Dartmouth College, Hanover, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4Arnold school of Public Health, University of South Carolina, Columbia, SC, 5Geisel School of Medicine at Dartmouth College, Hanover, NH

    Background/Purpose: Clinical trials with systemic sclerosis (SSc) patients have yet to lead to an FDA approved treatment.  We have adopted a gene fold-change analysis called…
  • Abstract Number: 2012 • 2019 ACR/ARP Annual Meeting

    A Composite IFN-Based Signature Is Associated with a Filgotinib-Specific Clinical Response in bDMARD-Experienced Rheumatoid Arthritis Patients

    Peter Taylor1, Bryan Downie 2, Emon Elboudwarej 3, Rachael Hawtin 3, Amer M. Mirza 3 and Jinfeng Liu 3, 1University of Oxford, Oxford, United Kingdom, 2Gilead Sciences, Inc., Foster Citty, CA, 3Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: Filgotinib (FIL), an oral, selective, Janus Kinase 1 (JAK1) inhibitor was effective in Phase 3 studies of active RA in patients (pts) with inadequate…
  • Abstract Number: 55 • 2019 ACR/ARP Annual Meeting

    A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis

    Anna Montgomery 1, Shang-Yang Chen 1, Deborah Winter 2 and Harris Perlman2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
  • Abstract Number: 579 • 2018 ACR/ARHP Annual Meeting

    Changes in DNA Methylation Identify Response to Treatment with Methotrexate and TNF Inhibitors Among RA Patients

    Cameron Adams1, Katie Marker1, Melissa Krueger2, Lisa Barcellos1 and Lindsey A. Criswell3, 1School of Public Health, UC Berkeley, Berkeley, CA, 2UC San Francisco, San Francisco,, CA, 3University of California San Francisco, San Francisco, CA

    Background/Purpose: Epigenetic modifications including DNA methylation are implicated in the development and progression of autoimmune diseases, such as rheumatoid arthritis  [MIM 180300]. Evidence indicates that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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