ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 1452 • ACR Convergence 2020

    Transcriptomic Meta-analysis Reveals a Core Transcriptional Program in Murine B Cell Anergy and Implicates Immunometabolic Regulation as a Central Pathway in Maintaining Non-responsiveness of Autoreactive B-cells in Both Mouse and Man

    Isaac Harley1, Bergren Crute2, Andrew Getahun2 and John Cambier3, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Colorado – Anschutz Medical Campus, Aurora, 3Univ, Aurora

    Background/Purpose: The mechanisms self-tolerance loss that lead to autoantibody-mediated autoimmune disease remain underdefined. The rapid reversibility of peripheral B-cell tolerance in murine models suggests that…
  • Abstract Number: 1787 • ACR Convergence 2020

    Differences in Chromatin Architecture Between Treatment Naïve Pediatric and Adult Lupus Patients

    Joyce Hui-Yuen1, Frank Jenkins2, Kaiyu Jiang3, Susan Malkiel4, Betty Diamond4 and James Jarvis5, 1Northwell LIJ Health System, Manhasset, NY, 2Northwell Health, Manhasset, 3University at Buffalo, Buffalo, NY, 4Northwell Health, Manhasset, NY, 5University at Buffalo Jacobs School of Medicine, Buffalo, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is possibly triggered by gene-environment interactions. We showed most of the SLE haplotypes encompass genomic regions enriched for epigenetic marks…
  • Abstract Number: 0027 • ACR Convergence 2020

    CYP2D6 Genotype and Reduced Codeine Analgesic Effect in Real-World Clinical Practice

    Daniel Carranza Leon1, Alyson Dickson2, Andrea Gaedigk3, C. Michael Stein2 and Cecilia Chung2, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, 3University of Missouri, Kansas City

    Background/Purpose: Codeine, a widely prescribed analgesic, is an inactive pro-drug that is metabolized to morphine, the active drug, by cytochrome P450 2D6 (CYP2D6), a highly…
  • Abstract Number: 1815 • ACR Convergence 2020

    Dynamic Changes in Microbiota Representation of a Gut Pathobiont and Clinical Disease Activity in Patients with Lupus Nephritis

    Doua Azzouz1, Ze Chen2, Zhi Li3, Peter Izmirly4, Jing Deng1, David Fenyo3, Jill Buyon1, Alexander Alekseyenko5 and Gregg Silverman6, 1Department of Medicine, NYU School of Medicine, New York, NY, 2Department of Microbiology, NYU School of Medicine, New York, NY, 3Institute for Systems Genetics, NYU School of Medicine, New York, NY, 4Department of Medicine, New York University School of Medicine, New York, NY, 5Medical University of South Carolina, Charleston, SC, 6Laboratory of B cell immunobiology, Department of Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: From a cross-sectional cohort, we have recently identified a candidate human gut pathobiont, Ruminococcus gnavus (RG) of the Lachnospiraceae family and Blautia genus that…
  • Abstract Number: 0036 • ACR Convergence 2020

    Molecular Phenotyping of Late-Stage Knee Osteoarthritis Synovium Through Total RNA-Sequencing

    Anusha Ratneswaran1, Chiara Pastrello1, Pratibha Potla2, Osvaldo Espin-Garcia2, Starlee Lively2, Anthony Perruccio3, Raj Rampersaud2, Rajiv Gandhi2 and Mohit Kapoor4, 1University Health Network, Toronto, ON, Canada, 2Krembil RI, Toronto, Canada, 3Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, 4Krembil RI, Toronto, ON, Canada

    Background/Purpose: Knee Osteoarthritis (OA) is a painful, disabling condition and molecular mechanisms underlying this disease are poorly understood. In recent years, OA is increasingly viewed…
  • Abstract Number: 1860 • ACR Convergence 2020

    An Integrative Approach to Identify Heritable and De Novo Genomic Variations in Psoriatic Arthritis Mutilans and Understand Its Systems Biology

    Sara Rahmati1, Quan Li1, Dafna Gladman2, Proton Rahman3 and Vinod Chandran2, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Memorial University of Newfoundland, Department of Medicine, St John's, Canada

    Background/Purpose: Psoriasis is a chronic autoimmune skin disease that burdens ~3% of North Americans. ~24% of psoriatic patients develop psoriasis arthritis (PsA), an inflammatory disease…
  • Abstract Number: 0072 • ACR Convergence 2020

    Characterizing Heterogeneity of Synovial Macrophages in Rheumatoid Arthritis Patients

    Shang-Yang Chen1, Yidan Wang2, Anna Montgomery2, Salina Dominguez2, Carla Cuda2, Gaurav Gadhvi1, Harris Perlman2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). While they are potent producers of…
  • Abstract Number: 1933 • ACR Convergence 2020

    Small Vessel Vasculitis Surrounding a Preserved Temporal Artery: Search for Tissue Biomarkers with Potential Diagnostic Value

    Georgina Espígol-Frigolé1, Roser Alba-Rovira2, Salvador Naranjo-Suárez3, Magda Terenas4, Sergio Prieto-González1, Marc Corbera-Bellalta3, Javier Marco-Hernández4, Marco A. Alba1, Farah Kamberovic3, Roberto Ríos-Garcés1, Jose Hernández-Rodríguez1 and Maria C. Cid1, 1Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain., Barcelona, Catalonia, Spain, 2Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, IRB-CELLEX. Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain, Barcelona, 3IDIBAPS, Barcelona, Spain, 4Hospital Clinic Barcelona, Barcelona, Spain

    Background/Purpose: Systemic vasculitides are complex and heterogeneous diseases with overlapping features that frequently pose a diagnostic challenge to clinicians. The temporal artery biopsy (TAB) is…
  • Abstract Number: 007 • 2020 Pediatric Rheumatology Symposium

    Dense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel Susceptibility Locus for Systemic Juvenile Idiopathic Arthritis

    Emily Shuldiner 1, Elaine Remmers 2, Miranda Marion 3, Marc Sudman 4, Colleen Satorius 5, International Childhood Arthritis Genetics Consortium (INCHARGE), Juvenile Arthritis Consortium for the Immunochip (JACI), Wendy Thomson 6, Michael Ombrello1, Patricia Woo 7, Carl Langefeld 8, Sampath Prahalad 9 and Susan Thompson 10, 1NIAMS, NIH, Bethesda, 2National Human Genome Research Institute, Bethesda, 3Wake Forest University, Winston-Salem, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5NHGRI, NIH, Bethesda, 6Manchester Academic Health Science Centre, Manchester, United Kingdom, 7London, United Kingdom, 8Winston Salem, 9Emory + Children's Pediatric Institute, Atlanta, 10Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among childhood…
  • Abstract Number: 55 • 2019 ACR/ARP Annual Meeting

    A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis

    Anna Montgomery 1, Shang-Yang Chen 1, Deborah Winter 2 and Harris Perlman2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
  • Abstract Number: 1018 • 2019 ACR/ARP Annual Meeting

    Renal Single Cell Genomics Links Type II Interferon and Lupus Nephritis in African-Americans

    Andrea Fava1, Yuji Zhang 2, Jill Buyon 3, Chaim Putterman 4, Nir Hacohen 5, Arnon Arazi 5, Celine Berthier 6, Deepak Rao 7, Michael Brenner 8, David Wofsy 9, Anne Davidson 10, Mathias Kretzler 11, David Hildeman 12, E. Steve Woodle 12, Betty Diamond 10, Thomas Tuschl 13, Evan Der 14, Hemant Suryawanshi 13, H. Michael Belmont 15, Peter Izmirly 16, Robert Clancy 16, The Accelerating Medicines Partnership 17 and Michelle Petri 18, 1Johns Hopkins University, Baltimore, 2University of Maryland, Baltimore, 3NYU School of Medicine, New York, 4Albert Einstein College of Medicine, New York, NY, 5Broad Institute, Cambridge, 6University of Michigan, Ann Arbor, MI, 7Brigham and Women's Hospital, Boston, MA, 8Brigham and Women’s Hospital:, Boston, 9UCSF, San Francisco, 10Feinstein Institutes for Medical Research, Manhasset, 11University of Michigan, Ann Arbor, 12University of Cincinnati, Cincinnati, 13Rockefeller Research Laboratories, New York, 14Albert Einstein College of Medicine, New York, 15New York University School of Medicine, Ney York, 16New York University School of Medicine, New York, 17Multiple Organizations, USA, 18Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Compared to Caucasian, African-American ethnicity is associated with a higher risk of developing systemic lupus erythematosus, lupus nephritis, high-risk histological features, resistance to treatment,…
  • Abstract Number: 1039 • 2019 ACR/ARP Annual Meeting

    Molecular Profiling Identifies Immunologic Subgroups and Informs Mechanism of Action of Baricitinib in SLE

    Thomas Dörner1, Yoshiya Tanaka 2, Michelle Petri 3, Josef Smolen 4, Daniel Wallace 5, Ernst Dow 6, Damiano Fantini 6, Richard Higgs 6, Guilherme Rocha 6, Brenda Crowe 6, Robert Benschop 6, Adam Abel 6, Nicole Byers 6, Maria Silk 6, Stephanie de Bono 6 and Robert Hoffman 6, 1Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Medical University of Vienna, Vienna, Austria, 5Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, 6Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Baricitinib is an oral selective Janus kinase (JAK) 1 and JAK2 inhibitor. In the Phase II, 24-week, randomized, placebo-controlled, double-blind study JAHH (NCT02708095), once-daily…
  • Abstract Number: 1041 • 2019 ACR/ARP Annual Meeting

    Computational Methods for Drug Repositioning of Systemic Sclerosis Using Gene Fold-Change and Network Analyses

    Dillon Popovich1, Michael Whitfield 2, Yue Wang 3, Guoshuai Cai 4 and Mengqi Huang 5, 1Geisel School of Medicine at Dartmouth College, Hanover, 2Geisel School of Medicine at Dartmouth College, Biomedical Data Science at Dartmouth College, Hanover, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4Arnold school of Public Health, University of South Carolina, Columbia, SC, 5Geisel School of Medicine at Dartmouth College, Hanover, NH

    Background/Purpose: Clinical trials with systemic sclerosis (SSc) patients have yet to lead to an FDA approved treatment.  We have adopted a gene fold-change analysis called…
  • Abstract Number: 2012 • 2019 ACR/ARP Annual Meeting

    A Composite IFN-Based Signature Is Associated with a Filgotinib-Specific Clinical Response in bDMARD-Experienced Rheumatoid Arthritis Patients

    Peter Taylor1, Bryan Downie 2, Emon Elboudwarej 3, Rachael Hawtin 3, Amer M. Mirza 3 and Jinfeng Liu 3, 1University of Oxford, Oxford, United Kingdom, 2Gilead Sciences, Inc., Foster Citty, CA, 3Gilead Sciences, Inc., Foster City, CA

    Background/Purpose: Filgotinib (FIL), an oral, selective, Janus Kinase 1 (JAK1) inhibitor was effective in Phase 3 studies of active RA in patients (pts) with inadequate…
  • Abstract Number: 579 • 2018 ACR/ARHP Annual Meeting

    Changes in DNA Methylation Identify Response to Treatment with Methotrexate and TNF Inhibitors Among RA Patients

    Cameron Adams1, Katie Marker1, Melissa Krueger2, Lisa Barcellos1 and Lindsey A. Criswell3, 1School of Public Health, UC Berkeley, Berkeley, CA, 2UC San Francisco, San Francisco,, CA, 3University of California San Francisco, San Francisco, CA

    Background/Purpose: Epigenetic modifications including DNA methylation are implicated in the development and progression of autoimmune diseases, such as rheumatoid arthritis  [MIM 180300]. Evidence indicates that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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