Abstracts tagged "genomics and rheumatoid arthritis (RA)"

Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting
Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis
Adrià Aterido¹, Jesús Tornero², Francisco J Blanco³, Benjamin Fernandez Gutierrez⁴, Antonio Gonzalez⁵, Juan D. Cañete⁶, Joan Maymó⁷, Mercedes Alperi-López⁸, Alejandro Olivé-Marqués⁹, Hector Corominas¹⁰, Víctor Martínez-Taboada¹¹, Isidoro Gonzalez-Alvaro¹², Antonio Fernandez-Nebro¹³, Alba Erra¹⁴, Simón Sánchez-Fernández¹⁵, María López-Lasanta¹, Mireia López-Corbeto¹, Raül Tortosa¹, Laia Codó¹⁶, Sara Marsal¹ and Antonio Julià¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, ⁵Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ⁶Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, ⁷Rheumatology Department, Hospital del Mar, Barcelona, Spain, ⁸Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁹Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ¹⁰Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ¹¹Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹²Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ¹³UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, ¹⁴Rheumatology Service, Hospital San Rafael, Barcelona, Spain, ¹⁵Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ¹⁶Life Sciences Department, Barcelona Supercomputing Centre, Barcelona, Spain
Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…
Abstract Number: 441 • 2017 ACR/ARHP Annual Meeting
Social Media Based, Direct-to-Patient Study Designed for Development of “from Home” Testing for Rheumatoid Arthritis Patients Is Feasible and Engaged Individuals with Distinct Clinical Characteristics
Kristen Warren¹, Olga Derbeneva¹, Francisco Flores¹, Michelle Frits², James Healy¹, Christine Iannaccone³, Omar Khalid¹, Krishna Morampudi¹, Nancy Shadick⁴, Michael Weinblatt⁴, Hemani Wijesuriya¹ and Robert Terbrueggen¹, ¹DxTerity, Rancho Dominguez, CA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Physicians equipped with low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment for rheumatoid arthritis…
Abstract Number: 63 • 2016 ACR/ARHP Annual Meeting
Identification of Immune Gene Modules in Good Responders to Adalimumab in Rheumatoid Arthritis
James OIiver¹, Darren Plant², Gisela Orozco¹, Samantha Smith¹, Kimme L. Hyrich³, Ann Morgan⁴, John Isaacs⁵, Anthony G. Wilson⁶ and Anne Barton^1,2, ¹Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust, Manchester, United Kingdom, ³Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain, ⁵Institute of Cellular Medicine, Newcastle University and National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, ⁶UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
Background/Purpose: Despite the revolutionary impact of TNF inhibitor (TNFi) therapy in rheumatoid arthritis (RA), up to 40% of patients fail to respond adequately. Whilst non-responder…
Abstract Number: 2556 • 2016 ACR/ARHP Annual Meeting
Deficient Expression of the Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Induces S Phase Arrest in RA Fibroblast-like Synoviocytes (FLS)
Shinji Matsuda¹, Deepa Hammaker², Steven Dowdy³, David L. Boyle⁴ and Gary Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³UC San Diego School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁵Medicine, UCSD, La Jolla, CA
Background/Purpose: LBH (Limb-bud and heart development) was recently identified as an RA risk gene that has abnormally methylated loci and a functional enhancer SNP in…
Abstract Number: 1255 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns in CD4+ T Reveal Significant Contribution of DNA Methylation to Rheumatoid Arthritis
Shicheng Guo^1,2, Ting Jiang^1,2, Rongsheng Wang^1,2, Yi Shen^1,2, Xiao Zhu³, Fengmin Bai^1,2, Qin Ding^1,2, Guangjie Chen⁴ and Dongyi He^1,2, ¹Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China, ²Arthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China, ³Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China, ⁴Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai, China
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence showed more and more importance of the epigenetic…
Abstract Number: 2454 • 2014 ACR/ARHP Annual Meeting
Genetic Influences on Rheumatoid Arthritis in African-Americans
Vincent A. Laufer^1,2, Richard J. Reynolds³, Maria I. Danila⁴, Gordon Wu⁵, Amit Patki⁵, Devin Absher⁶, Carl D. Langefeld⁷, R. Curtis Hendrickson⁸, Elliot J. Lefkowitz⁹, Ted R. Mikuls¹⁰, Peter K. Gregersen¹¹, Elizabeth E. Brown⁸, Robert P. Kimberly⁸, John B. Harley¹², Donna K. Arnett⁸, Hemant K. Tiwari⁵ and S. Louis Bridges Jr.^8,13, ¹Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham Medical Scientist Training Program, Birmingham, AL, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁶Hudson Alpha Institute for Biotechnology, Huntsville, AL, ⁷Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Microbiology, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ¹¹Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ¹²Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rheumatoid arthritis (RA) affects 0.5-1% of the population worldwide. The genetics of RA has been analyzed in large European and Asian studies, but much…
Abstract Number: 1903 • 2013 ACR/ARHP Annual Meeting
PIK3CD Overexpression In The Synovial Membrane Of Rheumatoid Arthritis Patients Is Associated With Response To Anti-TNF Therapy
Antonio Julià¹, Gabriela Ávila¹, Raquel Celis², Raimon Sanmarti³, Julio Ramirez⁴, Sara Marsal¹ and Juan D. Cañete³, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: The mechanisms by which Rheumatoid Arthritis (RA) patients do not respond to TNF blockade are still poorly characterized. The goal of this study is…
Abstract Number: 1615 • 2012 ACR/ARHP Annual Meeting
Evidence for Distinct Roles of Environmental and Genetic Factors in the Emergence of Anti Citrullinated-Protein Antibodies Positive Rheumatoid Arthritis-an Epidemiological Investigation in Twins
Aase Haj Hensvold¹, Patrik KE Magnusson², Monika Hansson³, Lena Israelsson⁴, Cecilia Carlens¹, Johan Askling⁵, Vivianne Malmström⁶, Lars Klareskog⁷ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Medical Epidemiology and Biostatistics, Swedish Twin Registry Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: The aim of the current study was to investigate the influence of genetic and environmental factors in developing anti citrullianted-proteins antibodies (ACPA) and ACPA…
Abstract Number: 1315 • 2012 ACR/ARHP Annual Meeting
Gene Expression Profiling and Pathway Changes Associated with Clinical Response to Tabalumab Blockade of Membrane Bound and Soluble B Cell Activating Factor in Rheumatoid Arthritis
Wendy J. Komocsar¹, Mark C. Genovese², Ernst R. Dow³, Poulabi Banerjee¹, Michelle A. Penny³, Eric P. Nantz¹, Sergey Stepaniants⁴, Anne Ho⁴, Pierre-Yves Berclaz¹ and Robert W. Hoffman¹, ¹Eli Lilly and Company, Indianapolis, IN, ²Division of Rheumatology, Stanford University, Palo Alto, CA, ³Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, ⁴Covance Genomics Laboratory LLC, Seattle, WA
Background/Purpose: Tabalumab, a monoclonal antibody neutralizing membrane bound and soluble B cell activating Factor (BAFF), has been shown to reduce the signs and symptoms of…
Abstract Number: 1000 • 2012 ACR/ARHP Annual Meeting
Epistatic Interaction Between BANK1 and BLK in Rheumatoid Arthritis: Results From a Large Trans-Ethnic Meta-Analysis
Emmanuelle Genin¹, Baptiste Coustet², Yannick Allanore³, Maria Teruel⁴, Arnaud L. Constantin⁵, Shigeto Tohma⁶, O. Vittecoq⁷, Hiroshi Furukawa⁸, Alejandro Balsa⁹, Thierry Schaeverbeke¹⁰, Miguel Angel González-Gay¹¹, Gilles Chiocchia¹², Naoyuki Tsuchiya¹³, Javier Martin¹⁴ and Philippe Dieude¹⁵, ¹INSERM UMR-S946, Paris, France, ²Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁵Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France, ⁶Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁷University Hospital, Rouen, France, ⁸Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan, ⁹Rheumatology, La Paz Hospital. IdiPaz, Madrid, Spain, ¹⁰Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ¹¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ¹²Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ¹³Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹⁴Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain, ¹⁵Rheumatology, APHP, Hopital Bichat, Paris, France
Background/Purpose: BANK1 and BLK belong to pleiotropic genes and recently a genetic and physical interaction between BANK1 and BLK has been detected in systemic lupus…
Abstract Number: 442 • 2012 ACR/ARHP Annual Meeting
Joint Effects of Known Genetic Markers of Rheumatoid Arthritis Risk and 25-Hydroxyvitamin D On Rheumatoid Arthritis Risk
Linda T. Hiraki¹, Chia-Yen Chen², Jing Cui³, Susan Malspeis⁴, Karen H. Costenbader⁴ and Elizabeth W. Karlson⁵, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ²Epidemiology, Harvard School of Public Health, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is a complex disease with both genetic and environmental risk factors. A number of susceptibility genes have been identified. Past studies…
Abstract Number: 420 • 2012 ACR/ARHP Annual Meeting
Loss-of-Co-Homozygosity Mapping and Exome Sequencing of a Syrian Pedigree Identified the Candidate Causal Mutation Associated with Rheumatoid Arthritis
Yukinori Okada¹, Namrata Gupta², Daniel Mirel², Stacey Gabriel², Thurayya Arayssi³, Faten Mouassess⁴, Walid AL Achkar⁴, Layla Kazkaz⁵ and Robert M. Plenge⁶, ¹Division of Rheumatology, Immunology, and Allergy, 1.Brigham and Women's Hospital, Harvard Medical School, 2.Program in Medical and Population Genetics, Broad Institute, Boston, MA, ²The Broad Institute, Cambridge, MA, ³Internal Medicine, Weill Cornell Medical College-Qatar, Doha, Qatar, ⁴Human Genetics, Molecular Biology and Biotechnology, Damascus, Syria, ⁵Tishreen Hospital and the Syrian Association for Rheumatology, Damascus, Syria, Damascus, Syria, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Although there are >50 rheumatoid arthritis (RA) risk loci that contain common variants, there are no known genomic loci that harbor rare mutations…

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