Abstracts tagged "Genomics and juvenile idiopathic arthritis (JIA)"

Abstract Number: 2032 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci
Laura A McIntosh¹, Miranda C Marion², Marc Sudman¹, Mary E Comeau², Sampath Prahalad³, John F. Bohnsack⁴, Johannes P Haas⁵, Carol A Wallace⁶, Daniel J Lovell⁷, Thomas A Griffin⁸, Mara L Becker⁹, Peter A Nigrovic^10,11, Marilynn Punaro¹², Carlos D Rosé¹³, Carol A Wise¹⁴, Halima Moncrieffe¹⁵, Timothy D Howard¹⁶, Carl D Langefeld¹⁷, Susan D Thompson^15,18 and Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA genetic registry, TREAT study, Understanding TNF Therapy in JIA Project, ¹Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, ³Pediatrics, Emory Children's Center, Atlanta, GA, ⁴Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT, ⁵German Centre for Rheumatology in Children and Young People, Garmisch-Partenkirchen, Germany, ⁶Pediatrics, Seattle Children's Hospital, Seattle, WA, ⁷Rheumatology, PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁸Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, ⁹Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ¹⁰Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ¹¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ¹²Pediatric Rheumatology, Texas Scottish Rite Hospital for Children, Dallas, TX, ¹³Pediatrics, Division of Rheumatology, Nemours/A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, ¹⁴Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, ¹⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁶Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, ¹⁷Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, ¹⁸Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease, affecting approximately 1 in 1,000 children. JIA is a complex genetic trait and…
Abstract Number: 2194 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing In Peripheral Blood Mononuclear Cells Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Juvenile Idiopathic Arthritis
Kaiyu Jiang¹, Xiaoyun Sun², Yanmin Chen¹, Yufeng Shen² and James N. Jarvis¹, ¹Pediatrics, The University at Buffalo, Buffalo, NY, ²Center for Computational Biology & Bioinformatics, Columbia University, New York, NY
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The aetiology of JIA remains largely unknown, but the interplay between genes…
Abstract Number: 2204 • 2013 ACR/ARHP Annual Meeting
Early Treatment With Methotrexate Is Associated With Extensive Re-Ordering Of The Neutrophil Transcriptome In Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James N. Jarvis², ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, The University at Buffalo, Buffalo, NY, ³Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: We have previously demonstrated a role for neutrophils in polyarticulartar juvenile idiopathic arthritis (JIA) disease pathogenesis. For example, JIA neutrophils show specific abnormalities in…
Abstract Number: 2206 • 2013 ACR/ARHP Annual Meeting
Detection Of State-Specific RNA Transcripts In Juvenile Idiopathic Arthritis Neutrophils Using RNA Sequencing
Kaiyu Jiang¹, Xiaoyun Sun², Yanmin Chen¹, Yufeng Shen² and James N. Jarvis¹, ¹Pediatrics, The University at Buffalo, Buffalo, NY, ²Center for Computational Biology & Bioinformatics, Columbia University, New York, NY
Background/Purpose: Once considered non-functional, the vast regions of the human genome that do not contain protein-coding genes are now known to contain important regulatory elements. …
Abstract Number: 1614 • 2012 ACR/ARHP Annual Meeting
Analysis of the Immunochip in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies 17 Loci At Genome-Wide Significance
Anne Hinks¹, Joanna Cobb¹, Miranda C. Marion², Marc Sudman³, John Bowes⁴, Kathryn J. A. Steel⁵, Mehdi Keddache⁶, John F. Bohnsack⁷, Stephen Guthery⁸, Lucy R. Wedderburn⁹, Johannes Peter Haas¹⁰, David N. Glass¹¹, Sampath Prahalad¹², Carl D. Langefeld¹³, Wendy Thomson⁵ and Susan D. Thompson³, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ³Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁶Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Pediatriacs, University of Utah, Salt Lake City, UT, ⁸Pediatrics, University of Utah, Salt Lake City, UT, ⁹Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ¹⁰German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ¹¹Divison of Rheumatology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH, ¹²Pediatrics, Emory Children's Center, Atlanta, GA, ¹³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC
Background/Purpose: Genome-wide (GW) association studies have been hugely successful in the identification of susceptibility loci for autoimmune diseases, interestingly many of the loci are shared…

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