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Abstracts tagged "Genomics and juvenile idiopathic arthritis (JIA)"

  • Abstract Number: 2032 • 2016 ACR/ARHP Annual Meeting

    Genome-Wide Association Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci

    Laura A McIntosh1, Miranda C Marion2, Marc Sudman1, Mary E Comeau2, Sampath Prahalad3, John F. Bohnsack4, Johannes P Haas5, Carol A Wallace6, Daniel J Lovell7, Thomas A Griffin8, Mara L Becker9, Peter A Nigrovic10,11, Marilynn Punaro12, Carlos D Rosé13, Carol A Wise14, Halima Moncrieffe15, Timothy D Howard16, Carl D Langefeld17, Susan D Thompson15,18 and Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA genetic registry, TREAT study, Understanding TNF Therapy in JIA Project, 1Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 3Pediatrics, Emory Children's Center, Atlanta, GA, 4Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT, 5German Centre for Rheumatology in Children and Young People, Garmisch-Partenkirchen, Germany, 6Pediatrics, Seattle Children's Hospital, Seattle, WA, 7Rheumatology, PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 8Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, 9Rheumatology, Children's Mercy Kansas City, Kansas City, MO, 10Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, 11Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 12Pediatric Rheumatology, Texas Scottish Rite Hospital for Children, Dallas, TX, 13Pediatrics, Division of Rheumatology, Nemours/A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, 14Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, 15Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 16Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, 17Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 18Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease, affecting approximately 1 in 1,000 children. JIA is a complex genetic trait and…
  • Abstract Number: 2194 • 2013 ACR/ARHP Annual Meeting

    RNA-Sequencing In Peripheral Blood Mononuclear Cells  Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Juvenile Idiopathic Arthritis

    Kaiyu Jiang1, Xiaoyun Sun2, Yanmin Chen1, Yufeng Shen2 and James N. Jarvis1, 1Pediatrics, The University at Buffalo, Buffalo, NY, 2Center for Computational Biology & Bioinformatics, Columbia University, New York, NY

    Background/Purpose:  Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The aetiology of JIA remains largely unknown, but the interplay between genes…
  • Abstract Number: 2204 • 2013 ACR/ARHP Annual Meeting

    Early Treatment With Methotrexate Is Associated With Extensive Re-Ordering Of The Neutrophil Transcriptome In Juvenile Idiopathic Arthritis

    Zihua Hu1, Kaiyu Jiang2, Mark B. Frank3, Yanmin Chen2 and James N. Jarvis2, 1Center for Computational Research, University at Buffalo, Buffalo, NY, 2Pediatrics, The University at Buffalo, Buffalo, NY, 3Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: We have previously demonstrated a role for neutrophils in polyarticulartar juvenile idiopathic arthritis (JIA) disease pathogenesis. For example, JIA neutrophils show specific abnormalities in…
  • Abstract Number: 2206 • 2013 ACR/ARHP Annual Meeting

    Detection Of State-Specific RNA Transcripts In Juvenile Idiopathic Arthritis Neutrophils Using RNA Sequencing

    Kaiyu Jiang1, Xiaoyun Sun2, Yanmin Chen1, Yufeng Shen2 and James N. Jarvis1, 1Pediatrics, The University at Buffalo, Buffalo, NY, 2Center for Computational Biology & Bioinformatics, Columbia University, New York, NY

    Background/Purpose: Once considered non-functional, the vast regions of the human genome that do not contain protein-coding genes are now known to contain important regulatory elements. …
  • Abstract Number: 1614 • 2012 ACR/ARHP Annual Meeting

    Analysis of the Immunochip in a Large Cohort of Juvenile Idiopathic Arthritis Cases Identifies 17 Loci At Genome-Wide Significance

    Anne Hinks1, Joanna Cobb1, Miranda C. Marion2, Marc Sudman3, John Bowes4, Kathryn J. A. Steel5, Mehdi Keddache6, John F. Bohnsack7, Stephen Guthery8, Lucy R. Wedderburn9, Johannes Peter Haas10, David N. Glass11, Sampath Prahalad12, Carl D. Langefeld13, Wendy Thomson5 and Susan D. Thompson3, 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 2Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 3Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 5Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 6Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Pediatriacs, University of Utah, Salt Lake City, UT, 8Pediatrics, University of Utah, Salt Lake City, UT, 9Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, 10German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, 11Divison of Rheumatology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH, 12Pediatrics, Emory Children's Center, Atlanta, GA, 13Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC

    Background/Purpose: Genome-wide (GW) association studies have been hugely successful in the identification of susceptibility loci for autoimmune diseases, interestingly many of the loci are shared…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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