ACR Meeting Abstracts

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Abstracts tagged "genomics and interferons"

  • Abstract Number: 523 • 2012 ACR/ARHP Annual Meeting

    Use of Global Gene Expression Profiling to Characterize Sjögren’s Patients Who Underexpress Interferon-Inducible Genes

    John A. Ice1, He Li2, Jennifer A. Kelly1, Indra Adrianto1, Stuart B. Glenn3, Kimberly S. Hefner4, Evan G. Vista5, Donald U. Stone6, Raj Gopalakrishnan7, Glen D. Houston8, David M. Lewis9, Michael Rohrer7, Pamela Hughes7, John B. Harley10, Courtney G. Montgomery11, James Chodosh12, James A. Lessard13, Juan-Manuel Anaya14, Barbara M. Segal15, Nelson L. Rhodus16, Lida Radfar17, Mark B. Frank1, R. Hal Scofield18, Christopher J. Lessard19 and Kathy Moser Sivils1, 1Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Hefner Eye Care and Optical Center, Oklahoma City, OK, 5Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, 6Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 7Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 8Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 9College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 11Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 13Valley Bone and Joint Clinic, Grand Forks, ND, 14School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 15Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 16University of Minnesota, Minneapolis, MN, 17University of Oklahoma Health Sciences Center, Oklahoma City, OK, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is a progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth.  We previously reported overexpression of interferon-inducible (IFI) genes…
  • Abstract Number: 525 • 2012 ACR/ARHP Annual Meeting

    Gene Expression Profiling in a Large Cohort of Europeans with Sjögren’s Syndrome Reveals Candidate Genes in Viral, Immune, and Interferon-Related Pathways

    He Li1, John A. Ice2, Jennifer A. Kelly3, Indra Adrianto2, Stuart B. Glenn4, Kimberly S. Hefner5, Evan G. Vista6, Donald U. Stone7, Raj Gopalakrishnan8, Glen D. Houston9, David M. Lewis10, Michael Rohrer8, Pamela Hughes8, John B. Harley11, Courtney G. Montgomery2, James Chodosh7, James A. Lessard12, Juan-Manuel Anaya13, Barbara M. Segal14, Nelson L. Rhodus15, Lida Radfar16, Mark B. Frank17, R. Hal Scofield18, Christopher J. Lessard19 and Kathy Moser Sivils3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Hefner Eye Care and Optical Center, Oklahoma City, OK, 6Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, 7Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 9Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Valley Bone and Joint Clinic, Grand Forks, ND, 13School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 14Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 15University of Minnesota, Minneapolis, MN, 16University of Oklahoma Health Sciences Center, Oklahoma City, OK, 17Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS), characterized by lymphocytic infiltration of exocrine glands, is a progressive autoimmune exocrinopathy present in 0.7-1% of Europeans. To better understand the…
  • Abstract Number: 2674 • 2012 ACR/ARHP Annual Meeting

    Cis-Expression Quantitative Trait Loci Analysis of Dysregulated Interferon-Pathway Genes Identifies HLA-C and OAS1 As Novel Candidates for Susceptibility to Sjögren’s Syndrome

    He Li1, John A. Ice2, Jennifer A. Kelly3, Indra Adrianto2, Stuart B. Glenn4, Kimberly S. Hefner5, Evan G. Vista6, Donald U. Stone7, Raj Gopalakrishnan8, Glen D. Houston9, David M. Lewis10, Michael Rohrer8, Pamela Hughes8, John B. Harley11, Courtney G. Montgomery2, James Chodosh7, James A. Lessard12, Juan-Manuel Anaya13, Barbara M. Segal14, Nelson L. Rhodus15, Lida Radfar16, Mark B. Frank17, R. Hal Scofield18, Christopher J. Lessard19 and Kathy Moser Sivils3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Hefner Eye Care and Optical Center, Oklahoma City, OK, 6Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, 7Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 9Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 11Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Valley Bone and Joint Clinic, Grand Forks, ND, 13School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 14Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 15University of Minnesota, Minneapolis, MN, 16University of Oklahoma Health Sciences Center, Oklahoma City, OK, 17Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is a progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth present in 0.7-1% of Europeans. Dysregulation of interferon…
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