ACR Meeting Abstracts

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Abstracts tagged "Genome Wide Association Studies"

  • Abstract Number: 0896 • ACR Convergence 2024

    Identification of Immune Pathways Regulated by a Non-Coding Variant at DNASE1L3/PXK/PDHB

    Michelle Morency1, Taehyeung Kim1 and Peter Nigrovic2, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Brookline, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a prevalent autoimmune disease in which aberrant immune attacks on joints and other tissues leads to permanent and disabling injury.…
  • Abstract Number: 0900 • ACR Convergence 2024

    Association Between Serum Urate, Gout, and Prostatic Cancer in European Male Populations: A Mendelian Randomization Study

    Sumanth Chandrupatla1, Nicholas Sumpter1, Tony Merriman2 and Jasvinder Singh3, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Homewood, AL, 3Baylor College of Medicine, Birmingham, AL

    Background/Purpose: Gout and serum urate (SU) are associated with prostate cancer risk. Previous Mendelian randomization (MR) studies have shown mixed results on the causal relationship…
  • Abstract Number: 0902 • ACR Convergence 2024

    Novel Role of TYK2mechanism in SLE Pathogenesis via T Cell and B Cell Pathways

    Joshua Hoffman1, Nicole Narayan2 and Mera Tilley1, 1Alumis Inc, South San Francisco, CA, 2Alumis, South San Francisco, CA

    Background/Purpose: SLE is a complex disease in need of novel therapies. Previously reported genome-wide association studies (GWAS) have identified a strong association between SLE and…
  • Abstract Number: 0910 • ACR Convergence 2024

    Reduced Adenosine-Mediated Regulatory Activity Exacerbated by an NT5E Loss of Function Mutation Is Linked to Tissue Inflammation and Hypertension in Systemic Lupus Erythematosus

    Katherine Owen1, Isaac Peabody2, Mikhail Olferiev3, Tyson Dawson2, Prathyusha Bachali4, Peter Kasson5, Amrie Grammer6, Mary Crow3 and Peter Lipsky2, 1RILITE, Charlottesville, VA, 2Ampel Biosolutions, Charlottesville, VA, 3Hospital for Special Surgery, New York, NY, 4AMPEL BioSolutions, Redmond, WA, 5University of Virginia, Charlottesville, VA, 6AMPEL LLC, Charlottesville, VA

    Background/Purpose: Adenosine is a purine nucleoside generated by the enzymatic activity of CD73/NT5E, that functions as an endogenous regulator of the immune system critical for…
  • Abstract Number: 0911 • ACR Convergence 2024

    Activating B Cells Facilitates the Discovery of Latent Disease-associated Variants

    David Murphy, Yao Fu, Jennifer Kelly, Richard Pelikan, Graham Wiley and Patrick Gaffney, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Although millions of disease-associated variants have been discovered using GWAS, most of these occur in non-coding regions and their mechanistic link to disease is…
  • Abstract Number: 0913 • ACR Convergence 2024

    The Association Between PTPN2 and Leukopenia in New Users of Azathioprine

    Puran Nepal1, Laura L. Daniel2, Jacy Zanussi2, Alyson L. Dickson3, Wei-Qi Wei3, Adriana M. Hung4, Nancy J. Cox3, Vivian K. Kawai3, Jonathan D. Mosley3, C. Michael Stein3, QiPing Feng3, Ge Liu3, Ran Tao3 and Cecilia P. Chung2, 1Vanderbilt University Medical Center, Vanderbilt, TN, 2University of Miami, Miami, FL, 3Vanderbilt University Medical Center, Nashville, TN, 4Veterans Administration Tennessee Valley Healthcare System, Nashville, TN

    Background/Purpose: Leukopenia is a common dose-dependent side effect of azathioprine and often results in discontinuation of the drug. Variants in TPMT and NUDT15 have been…
  • Abstract Number: 0914 • ACR Convergence 2024

    RAB19 and Azathioprine-Associated Pancreatic Injury in Patients Taking Azathioprine

    Shailja C. Shah1, Tyler S. Reese2, Laura L. Daniel3, Puran Nepal4, Jacy Zanussi3, Alyson L. Dickson2, Ran Tao2, Adriana M. Hung5, Wei-Qi Wei2, C. Michael Stein2, QiPing Feng2 and Cecilia P. Chung3, 1University of California, San Diego, San Diego, CA, 2Vanderbilt University Medical Center, Nashville, TN, 3University of Miami, Miami, FL, 4Vanderbilt University Medical Center, Vanderbilt, TN, 5Veterans Administration Tennessee Valley Healthcare System, Nashville, TN

    Background/Purpose: Pancreatitis is a rare, but potentially life-threatening adverse event associated with the use of azathioprine. Prior studies have found an association between the HLA…
  • Abstract Number: 0915 • ACR Convergence 2024

    APOH Locus Associated with Higher Anti-Beta-2-Glycoprotein 1 Antibody Levels Paradoxically Protects Against Venous Thromboembolism

    Yiming Luo, Lili Liu, Atlas Khan, R. Graham Barr, Elana Bernstein and Krzysztof Kiryluk, Columbia University Irving Medical Center, New York, NY

    Background/Purpose: Anti-Beta-2-glycoprotein 1 antibody (anti-B2GP1) is associated with antiphospholipid syndrome (APS), a rare autoimmune disease that causes venous thromboembolism (VTE). APOH, which expresses the B2GP1…
  • Abstract Number: 1803 • ACR Convergence 2024

    Genetics of eGFR Variability as a Proxy for Lupus Nephritis in Patients with Systemic Lupus Erythematosus

    Magdalena Riedl Khursigara1, Nicholas Gold2, Thai-Son Tang3, JingJing Cao4, Daniela Dominguez4, Marisa Klein-Gitelman5, Dafna Gladman6, Daniel Goldman7, Elizabeth Harvey4, Mariko Ishimori8, Caroline Jefferies9, Diane Kamen10, Sylvia Kamphuis11, Andrea Knight12, Chia-Chi Lee13, Deborah Levy2, Damien Noone4, Karen Onel14, Christine Peschken15, Michelle Petri7, Janet Pope16, Eleanor Pullenayegum4, Earl Silverman17, Zahi Touma18, Murray Urowitz19, Daniel Wallace20, Joan Wither21 and Linda Hiraki2, and Systemic Lupus Erythematosus Collaborative Clinics (SLICC), 1University of Toronto, Cambridge, MA, 2The Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto, Mississauga, ON, Canada, 4The Hospital for Sick Children, Toronto, Canada, 5Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 6University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 7Johns Hopkins University School of Medicine, Timonium, MD, 8Cedars-Sinai Health System, Los Angeles, CA, 9Cedars-Sinai Medical Center, Beverly Hills, CA, 10Medical University of South Carolina, Charleston, SC, 11Erasmus University Medical Center, Rotterdam, Netherlands, 12Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 13Cedars-Sinai Medical Center, Los Angeles, CA, 14HSS, New York, NY, 15University of Manitoba, Winnipeg, MB, Canada, 16University of Western Ontario, London, ON, Canada, 17Silverman, Toronto, ON, Canada, 18University of Toronto, Toronto, ON, Canada, 19Self employed, Toronto, ON, Canada, 20Cedars Sinai Medical Center, Studio City, CA, 21University Health Network, Toronto, ON, Canada

    Background/Purpose: Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus (SLE). We performed genome wide association studies (GWAS)…
  • Abstract Number: 2289 • ACR Convergence 2024

    Associations Between Protein Quantitative Trait Loci and Risk of Primary Sjögren’s Syndrome: A Mendelian Randomization Study

    Benjamin Zuckerman1, Alasdair Warwick2, art Schuermans3, Mark Gibson4, Ioasaf Karafotias5, Zijing Yang1, Carine moezinia6, Mark Russell7, Chris Wincup8, James Galloway9 and Sizheng Zhao10, 1King's College London, London, England, United Kingdom, 2University college London, London, United Kingdom, 3KU Leuven, Leuven, Belgium, 4King's College London, Newmarket, United Kingdom, 5King's College London, London, United Kingdom, 6univerity college hospital, London, United Kingdom, 7King's College London, London, United Kingdom, 8King's College Hospital, London, United Kingdom, 9Centre for Rheumatic Diseases, King's College London, London, United Kingdom, 10Centre for Musculoskeletal Research, The University of Manchester, Liverpool, United Kingdom

    Background/Purpose: The pathophysiology of primary Sjögren’s disease involves the interaction of genetic, epigenetic, and environmental factors. With limited treatment options for severe disease, a detailed understanding…
  • Abstract Number: 2533 • ACR Convergence 2024

    Genome-wide Association of Rheumatoid Arthritis in the African Ancestry Identifies HLA Amino Acid Polymorphisms of Risk

    Harrison Zhang1, Saori Sakaue2, Daniel Posner3, Jing Cui4, Dorris Yang5, Ashley Budu-Aggrey6, Yuk-Lam Ho3, Lauren Costa3, Rachael Matty3, Selena Huang1, Paul Monach7, Kazuyoshi Ishaigaki8, Monika Maripuri7, Connor Melley7, Vidisha Tanukonda7, Rahul Sangar3, Gregory McDermott9, Mary Jeffway1, Vincent Laufer10, Yukinori Okada11, Ian Scott12, S. Louis Bridges13, Kelly Cho3, Chuan Hong14, Jennifer E. Huffman15, Tianxi Cai16, Soumya Raychaudhuri1 and Katherine Liao1, and the VA Million Veteran Program, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Cambridge, MA, 3U.S. Department of Veterans Affairs, Boston, MA, 4Brigham Women's Hospital, Boston, MA, 5Harvard Medical School, Cambridge, MA, 6Bristol Medical School, Manchester, United Kingdom, 7VA Boston Healthcare System, Boston, MA, 8Keio University School of Medicine, Tokyo, Japan, 9Brigham and Women's Hospital, Brookline, MA, 10Michigan Medicine, Birmingham, AL, 11Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, 12School of Medicine, Keele University, Keele, United Kingdom, 13Division of Rheumatology, Weill Cornell Medical College, New York, NY, 14Duke University, Durham, NC, 15VA Boston Healthcare System, Palo Alto, 16Harvard T.H. Chan School of Public Health, Boston, MA

    Background/Purpose: The association between RA and the MHC is largely explained by five amino acid (AA) positions: DRB1 positions 11, 13, 71, and 74, HLA-B…
  • Abstract Number: 2602 • ACR Convergence 2024

    Genetics of Sex Dimorphism in Clinical Manifestations of Systemic Lupus Erythematosus

    Caseng Zhang1, Nicholas Gold2, Raffaella Carlomagno3, JingJing Cao4, Daniela Dominguez4, Dafna Gladman5, Mariko Ishimori6, Caroline Jefferies7, Diane Kamen8, Sylvia Kamphuis9, Marisa Klein-Gitelman10, Andrea Knight11, Chia-Chi Lee12, Deborah Levy2, Lawrence Ng2, Karen Onel13, Andrew Paterson4, Christine Peschken14, Janet Pope15, Earl Silverman16, Zahi Touma17, Murray Urowitz18, Daniel Wallace19, Joan Wither20 and Linda Hiraki2, 1University of Ottawa, Ottawa, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Lausanne University Hospital, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, Canada, 5University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Cedars-Sinai Health System, Los Angeles, CA, 7Cedars-Sinai Medical Center, Beverly Hills, CA, 8Medical University of South Carolina, Charleston, SC, 9Erasmus University Medical Center, Rotterdam, Netherlands, 10Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 11Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 12Cedars-Sinai Medical Center, Los Angeles, CA, 13HSS, New York, NY, 14University of Manitoba, Winnipeg, MB, Canada, 15University of Western Ontario, London, ON, Canada, 16Silverman, Toronto, ON, Canada, 17University of Toronto, Toronto, ON, Canada, 18Self employed, Toronto, ON, Canada, 19Cedars Sinai Medical Center, Studio City, CA, 20University Health Network, Toronto, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease with multi-organ involvement and a strong female predominance. Prior studies demonstrated sex dimorphism in…
  • Abstract Number: 0958 • ACR Convergence 2023

    Shared Genetic Susceptibility Between Systemic Sclerosis and Primary Biliary Cholangitis: Analyses from Genome-Wide Association Studies

    Yiming Luo1, Atlas Khan2, Gabriel Perreault3, Lili Liu2, Cue Hyunkyu Lee4, Pravitt Gourh5, Sydney Pomenti3, Krzysztof Kiryluk2 and Elana Bernstein6, 1Division of Rheumatology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 2Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 3Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 4Department of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY

    Background/Purpose: Systemic sclerosis (SSc) is a multi-system autoimmune disorder characterized by organ inflammation, fibrosis, and vasculopathy. Primary biliary cholangitis (PBC) is an autoimmune disorder involving…
  • Abstract Number: 1710 • ACR Convergence 2023

    Genetic Associations in Juvenile Idiopathic Arthritis Determined with an Electronic Health Record Based Approach

    Elizabeth Jasper, Srushti Gangireddy, Henry Ong, Jacklyn Hellwege, Todd Edwards, Digna Velez Edwards, Wei-Qi Wei and Anna Patrick, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Juvenile idiopathic arthritis (JIA) encompasses multiple forms of pediatric autoimmune arthritis. Research studies in JIA are complicated by disease heterogeneity and difficulties gathering large…
  • Abstract Number: 1833 • ACR Convergence 2023

    Development of a Polygenic Risk Model for Therapeutic Response to Bedtime Sublingual Cyclobenzaprine (TNX-102 SL*) in Fibromyalgia Based on Polygenic Single Nucleotide Polymorphism (SNP)-Count Scores

    Jeffrey Rosenfeld1, Greta Linse2, Sally Slipher2, Candace Flint3, Annie Iserson3, Herbert Harris4, Jean Engels3, Gregory Sullivan5 and Seth Lederman6, 1Tonix Pharmaceuticals, Chatham, NJ, 2Montana State University, Bozeman, MT, 3Tonix Pharmaceuticals, New York, NY, 4Tonix Pharmaceuticals, Chapel Hill, NC, 5Tonix Pharmaceuticals Inc, Chatham, NJ, 6Tonix Pharmaceuticals, South Dartmouth, MA

    Background/Purpose: Fibromyalgia (FM) is characterized by widespread pain, non-restorative sleep, fatigue, and cognitive dysfunction. TNX-102 SL is a sublingual cyclobenzaprine tablet designed for daily use…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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