Abstracts tagged "genome and population studies"

Abstract Number: 64 • 2016 ACR/ARHP Annual Meeting
Enrichment of Immune Pathways in Genes Under Geographically Restricted Adaptation in the Gullah African American Population of South Carolina
Paula S. Ramos¹, Satria Sajuthi², Wei-Min Chen³, Jasmin Divers², Jyotika K. Fernandes⁴, Gary S. Gilkeson⁴, Kelly J. Hunt⁵, Diane L. Kamen⁴, Uma Nayak³, W. Timothy Garvey⁶, Michèle M. Sale⁷ and Carl D. Langefeld², ¹Departments of Medicine and Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁶Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…
Abstract Number: 88 • 2015 ACR/ARHP Annual Meeting
Integrating Evidence for Genetic Association and Natural Selection Helps Detect New Systemic Lupus Erythematosus Risk Loci in African-Americans
Paula S. Ramos¹, Satria Sajuthi², Jasmin Divers³, Kenneth M. Kaufman⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁸, Jyotika K. Fernandes⁷, Ida J. Spruill⁹, Robert P. Kimberly¹⁰, John B. Harley¹¹, W. Timothy Garvey¹², Michèle M. Sale¹³ and Carl D. Langefeld², ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Medicine, Medical University of South Carolina, Charleston, SC, ⁸Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁹Nursing, Medical University of South Carolina, Charleston, SC, ¹⁰Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹²Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ¹³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: In many rheumatologic and autoimmune diseases African Americans (AA) have a higher prevalence and greater disease severity than other ethnicities. We posit that population-specific…

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