genetics Archives - Page 21 of 26 - ACR Meeting Abstracts

Abstract Number: 172 • 2017 ACR/ARHP Annual Meeting
Optimizing Precision Medicine By Using Genetics to Assign Diagnostic Prior Probabilities to Patients with Synovitis
Rachel Knevel^1,2,3,4, Chikashi Terao^5,6,7, Jing Cui^1,8, Kamil Slowikowski^2,9,10, TWJ Huizinga³, Elizabeth Karlson¹¹ and Soumya Raychaudhuri^1,2,12,13, ¹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Bosten, MA, ⁵Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ⁶Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan, ⁷Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁸Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ¹⁰Division of Genetics, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ¹¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹²Department of Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ¹³Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: As the cost of genome-wide genotyping plummets, and biobanking efforts integrating medical records and genetics are rapidly expanding, many patients will have genotyping available…
Abstract Number: 2937 • 2017 ACR/ARHP Annual Meeting
Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease
Chisato Shimizu¹, Jihoon Kim², Hariklia Eleftherohorinou³, Victoria Wright³, Long Hoang⁴, Adriana Tremoulet⁵, Alessandra Franco⁶, Martin Hibberd⁴, Atsushi Takahashi^7,8, Michiaki Kubo⁹, Kaoru Ito¹⁰, Toshihiro Tanaka^10,11, Yoshihiro Onouchi^10,12, Lachlan Coin³, Michael Levin³, Jane Burns¹³ and Hiroko Shike¹⁴, ¹Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, ²Medicine, University California San Diego, School of Medicine, Division of Biomedical Informatics, La Jolla, CA, ³Imperial College London, London, United Kingdom, ⁴Genome Institute of Singapore, Singapore, Singapore, ⁵Pediatrics, University California San Diego, School of Medicine, La Jolla, CA, ⁶Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, ⁷Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ⁸Department of Genomic Medicine, National Cerebral And Cardiovascular Center, Suita, Japan, ⁹RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ¹⁰Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ¹¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo, Japan, ¹²Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan, ¹³Pediatrics, University California San DIego, School of Medicine, San Diego, CA, ¹⁴Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Host genetics influence susceptibility to Kawasaki disease (KD), an acute pediatric vasculitis, and genome wide association studies (GWAS) have detected variants with modest effects…
Abstract Number: 68 • 2017 Pediatric Rheumatology Symposium
HLA-DRB1 in Non-Hispanic African American Children with Juvenile Idiopathic Arthritis and Chronic Anterior Uveitis
Lai Hin Kimi Chan¹, Courtney McCracken¹, Kirsten Jenkins², Steven Yeh³, Purnima Patel⁴, Sampath Prahalad¹ and Sheila Angeles-Han⁵, ¹Pediatrics, Emory University School of Medicine, Atlanta, GA, ²Children's Healthcare of Atlanta, Atlanta, GA, ³Ophthalmology, Emory University School of Medicine, Atlanta, GA, ⁴Emory University School of Medicine, Atlanta, GA, ⁵Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: HLA-DRB1*08, 11 and 13 are strong risk alleles for various juvenile idiopathic arthritis (JIA) subtypes. We reported that carriage of DRB1*11 and *13 increased…
Abstract Number: 1559 • 2016 ACR/ARHP Annual Meeting
Shared Genetic Predisposition in Rheumatoid Arthritis–Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: A Genetic Association Study
Pierre-Antoine Juge¹, Raphaël Borie², Caroline Kannengiesser³, Steven Gazal³, Patrick Revy⁴, Lidwine Wemeau-Stervinou⁵, Marie-Pierre Debray⁶, Sébastien Ottaviani⁷, Sylvain Adam-Marchand⁸, Nadia Nathan⁹, Gabriel Thabut¹⁰, Christophe Richez¹¹, Hilario Nunes¹², Isabelle Callebaut¹³, Aurélien Justet², Nicolas Leulliot¹⁴, Amélie Bonnefond¹⁵, David Salgado¹⁶, Pascal Richette¹⁷, Jean-Pierre Desvignes¹⁶, Huguette Lioté¹⁸, Philippe Froguel¹⁵, Yannick Allanore¹⁹, Olivier Sand¹⁵, Claire Dromer²⁰, René-Marc Flipo²¹, Annick Clément⁹, Christophe Béroud²², Jean Sibilia²³, Baptiste Coustet^1,24, Vincent Cottin²⁵, Marie-Christophe Boissier²⁶, Benoit Wallaert²⁷, Thierry Schaeverbeke²⁸, Florence Dasto le Moal²⁹, Aline Frazier¹⁷, Christelle Ménard³⁰, Martin Soubrier³¹, Nathalie Saidenberg²⁹, Dominique Valeyre³², Serge Amselem⁹, Catherine Boileau³, Bruno Crestani² and Philippe Dieudé¹, ¹Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ²Pneumologie A, Hôpital Bichat - Claude Bernard, Paris, France, ³Génétique, Hôpital Bichat - Claude Bernard, Paris, France, ⁴Laboratory of Genome Dynamics in the Immune System, Institut Imagine, Paris, France, ⁵Pneumologie, CHRU de Lille, Lille, France, ⁶Université Paris-Diderot, Paris, France, ⁷Rheumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ⁸Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, ⁹Pneumologie pédiatrique, Hôpital Trousseau, Paris, France, ¹⁰Pneumologie B, Hôpital Bichat - Claude Bernard, Paris, France, ¹¹Rhumatologie, Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, ¹²Pneumologie B, Hôpital Avicenne, Paris, France, ¹³CNRS UMR_7590, Paris, France, ¹⁴Laboratoire de cristallographie et RMN biologiques, UMR CNRS 8015, Paris, France, ¹⁵CNRS UMR_8199, Lille, France, ¹⁶UMR_S 910, Marseille, France, ¹⁷Rhumatologie, Hôpital Lariboisière, Paris, France, ¹⁸Pneumologie A, Hôpital Tenon, Paris, France, ¹⁹Rhumatologie A, Hôpital Cochin, Paris, France, ²⁰Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, ²¹Rhumatologie, CHU Lille, Lille, France, ²²INSERM UMR_S 910, Marseille, France, ²³Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁴Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, ²⁵Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, ²⁶Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²⁷Pneumology, CHRU, Lille CEDEX, France, ²⁸Rheumatology, CHU Bordeaux, Bordeaux, France, ²⁹Rhumatologie, Hôpital Avicenne, Paris, France, ³⁰Pneumologie Pédiatrique, Hôpital Trousseau, Paris, France, ³¹Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ³²Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France
Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality for rheumatoid arthritis (RA) patients. Despite its high prevalence and mortality, little…
Abstract Number: 1573 • 2016 ACR/ARHP Annual Meeting
Major Histocompatibility Antigen HLA-DQ6.1 (DQA1*0103/DQB1*0601) Increases Rheumatoid Arthritis Risk Independent of Shared Epitope Among Indians
Able Lawrence¹, Swayam Prakash², Uddalak Bharadwaj³, Amita Aggarwal⁴, Ramnath Misra⁴ and Suraksha Agrawal², ¹Clinical Immunology, SGPGIMS, Lucknow, India, ²Medical Genetics, SGPGIMS, Lucknow, India, ³MD Anderson Cancer Center, Houston, TX, ⁴Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: The association of HLA-DRB1 shared epitope (SE) with rheumatoid arthritis (RA) does not completely explain MHC association. The HLA-DRB1 alleles are classified into high…
Abstract Number: 2032 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci
Laura A McIntosh¹, Miranda C Marion², Marc Sudman¹, Mary E Comeau², Sampath Prahalad³, John F. Bohnsack⁴, Johannes P Haas⁵, Carol A Wallace⁶, Daniel J Lovell⁷, Thomas A Griffin⁸, Mara L Becker⁹, Peter A Nigrovic^10,11, Marilynn Punaro¹², Carlos D Rosé¹³, Carol A Wise¹⁴, Halima Moncrieffe¹⁵, Timothy D Howard¹⁶, Carl D Langefeld¹⁷, Susan D Thompson^15,18 and Boston Children’s JIA Registry, JIA gene expression studies, NIAMS JIA genetic registry, TREAT study, Understanding TNF Therapy in JIA Project, ¹Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, ³Pediatrics, Emory Children's Center, Atlanta, GA, ⁴Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT, ⁵German Centre for Rheumatology in Children and Young People, Garmisch-Partenkirchen, Germany, ⁶Pediatrics, Seattle Children's Hospital, Seattle, WA, ⁷Rheumatology, PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁸Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC, ⁹Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ¹⁰Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ¹¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ¹²Pediatric Rheumatology, Texas Scottish Rite Hospital for Children, Dallas, TX, ¹³Pediatrics, Division of Rheumatology, Nemours/A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, ¹⁴Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX, ¹⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁶Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC, ¹⁷Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, ¹⁸Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease, affecting approximately 1 in 1,000 children. JIA is a complex genetic trait and…
Abstract Number: 2033 • 2016 ACR/ARHP Annual Meeting
A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Kaiyu Jiang³, Michael Buck², Yanmin Chen³, Halima Moncrieffe⁴, Laura Brungs⁴, Tao Liu⁵ and Ting Wang⁶, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁶Genetics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Polyarticular juvenile idiopathic arthritis (JIA) is a complex trait characterized by gene-environment interactions. While we are beginning to identify multiple genomic regions associated with…
Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting
Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis
Yukinori Okada¹, Akari Suzuki², Katsunori Ikari³, Chikashi Terao⁴, Yuta Kochi², Koichiro Ohmura⁵, Koichiro Higasa⁵, Masato Akiyama², Kyoto Ashikawa², Masahiro Kanai², Jun Hirata¹, Naomasa Suita¹, Yik-Ying Teo⁶, Huji Xu⁷, Sang-Cheol Bae⁸, Yukihide Momozawa², koichi Matsuda⁹, Shigeki Momohara¹⁰, Atsuo Taniguchi¹⁰, Ryo Yamada⁵, Tsuneyo Mimori⁵, Michiaki Kubo², Matthew A. Brown¹¹, Soumya Raychaudhuri¹², Fumihiko Matsuda⁵, Hisashi Yamanaka¹⁰, Yoichiro Kamatani² and Kazuhiko Yamamoto⁹, ¹Osaka University, Osaka, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, ⁷The Second Military Medical University, Shanghai, Japan, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ⁹The University of Tokyo, Tokyo, Japan, ¹⁰Tokyo Women's Medical University, Tokyo, Japan, ¹¹The University of Queensland Diamantina Institute, Brisbane, Australia, ¹²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
Abstract Number: 2275 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Gout in New Zealand Polynesian People
Tanya Flynn¹, Ruth Topless¹, Murray Cadzow¹, Amanda Phipps-Green¹, Nick Burns¹, Nicola Dalbeth², Lisa K. Stamp³, Jennie Harre Hindmarsh⁴ and Tony R. Merriman⁵, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ⁵Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: The prevalence of gout in New Zealand Polynesian (Māori and Pacific) populations is approximately twice that of the New Zealand European population, with a…
Abstract Number: 2276 • 2016 ACR/ARHP Annual Meeting
Pleiotropic Effect of ABCG2 in Gout
Tony R. Merriman¹, Amanda Phipps-Green², James Boocock², Philip Riches³, Anne-Kathrin Tausche⁴, Timothy Radstake⁵, Matthijs Janssen⁶, Leo .A.B. Joosten⁷, Tim L Jansen⁸, Alexander So⁹, Jennie Harre Hindmarsh¹⁰, Lisa K. Stamp¹¹, Nicola Dalbeth¹² and Rebekah Wrigley², ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Edinburgh, Edinburgh, United Kingdom, ⁴Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ⁵Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Department of Rheumatology, Rijnstate Hospital Arnhem, Arnhem, Netherlands, ⁷Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ⁸Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁹Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, ¹⁰Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ¹¹University of Otago, Christchurch, New Zealand, ¹²University of Auckland, Auckland, New Zealand
Background/Purpose: The ABCG2 Q141K (rs2231142) variant is an established cause of hyperuricaemia in Europeans. Although the effect size of ABCG2 rs2231142 on serum urate levels…
Abstract Number: 2277 • 2016 ACR/ARHP Annual Meeting
Exon Sequencing Reveals a Significant Burden of Non-Synonymous Variants in Both SLC22A11 (OAT4) and SLC22A12 (URAT1) in European Hyperuricemic Individuals
Tanya Flynn¹, James Boocock¹, Murray Cadzow¹, Ruth Topless¹, Amanda Phipps-Green¹, Nicola Dalbeth², Lisa K. Stamp³, David B. Mount⁴, Asim Mandal⁴, Hyon K. Choi⁵, Eli A. Stahl⁶ and Tony R. Merriman⁷, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Common variants within the uric acid transporter genes SLC22A11 (OAT4) and SLC22A12 (URAT1) have been associated with hyperuricaemia and gout in multiple populations, but…
Abstract Number: 2420 • 2016 ACR/ARHP Annual Meeting
Investigating Genome-Wide Inbreeding Coefficients and Age of Diagnosis in a Multi-Ethnic Population of Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Chen Di Liao¹, Deanna Morra¹, Daniela Dominguez¹, Shazia Ali¹, Deborah M. Levy², Earl Silverman³, Andrew Paterson¹ and Linda T Hiraki¹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Genetics plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Up to 20% of those affected with SLE are diagnosed in…
Abstract Number: 3098 • 2016 ACR/ARHP Annual Meeting
The Occurrence of Peripheral Arthritis Mutilans in Psoriatic Arthritis Is Associated with Certain Major Histocompatibility Class I Alleles
Jon T. Giles¹, Deepak R. Jadon², Muhammad Haroon³, Jing Bi⁴, Eleanor Korendowych², William Tillett², Oliver FitzGerald⁵, Robert Winchester⁴ and Neil J. McHugh², ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ³St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ⁴Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁵St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Several human leukocyte antigen (HLA) Class I loci encoding the major histocompatibility complex (MHC) have been implicated both in psoriatic arthritis (PsA) susceptibility and…
Abstract Number: 3122 • 2016 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Association Study of Hand Osteoarthritis
Michelle S. Yau^1,2, Roby Joehanes³, Yi-Hsiang Hsu³, Douglas P. Kiel⁴ and David T. Felson⁵, ¹Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁴Institute for Aging Research, Institute for Aging Research, Hebrew Senior Life, Harvard Medical School, Boston, MA, USA, Boston, MA, ⁵Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose: Heritability of hand osteoarthritis (OA) has been estimated to be as high as 65%. Despite having a strong genetic component, genome-wide linkage and association…
Abstract Number: 71 • 2016 ACR/ARHP Annual Meeting
A Rare Coding Allele in IFIH1 is Protective for Psoriatic Arthritis
Ashley Budu-Aggrey^1,2, John Bowes², Philip E. Stuart³, Matthew Zawistowski⁴, Lam C. Tsoi⁴, Rajan P. Nair⁵, Eleanor Korendowych⁶, Neil J McHugh⁶, James T. Elder⁵, Anne Barton^1,7,8 and Soumya Raychaudhuri⁹, ¹NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, ³Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Royal National Hospital for Rheumatic Diseases and Dept Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁷Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁸The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, ⁹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis associated with psoriasis estimated to present in approximately 14% of psoriasis patients in the UK. As a…

Abstracts tagged "genetics"

Optimizing Precision Medicine By Using Genetics to Assign Diagnostic Prior Probabilities to Patients with Synovitis

Genetic Variants in HLA-C and Class I Pathway Genes Influence Susceptibility to Kawasaki Disease

HLA-DRB1 in Non-Hispanic African American Children with Juvenile Idiopathic Arthritis and Chronic Anterior Uveitis

Shared Genetic Predisposition in Rheumatoid Arthritis–Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: A Genetic Association Study

Major Histocompatibility Antigen HLA-DQ6.1 (DQA10103/DQB10601) Increases Rheumatoid Arthritis Risk Independent of Shared Epitope Among Indians

Genome-Wide Association Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci

A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis

Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis

Genome-Wide Association Study of Gout in New Zealand Polynesian People

Pleiotropic Effect of ABCG2 in Gout

Exon Sequencing Reveals a Significant Burden of Non-Synonymous Variants in Both SLC22A11 (OAT4) and SLC22A12 (URAT1) in European Hyperuricemic Individuals

Investigating Genome-Wide Inbreeding Coefficients and Age of Diagnosis in a Multi-Ethnic Population of Childhood-Onset Systemic Lupus Erythematosus (cSLE)

The Occurrence of Peripheral Arthritis Mutilans in Psoriatic Arthritis Is Associated with Certain Major Histocompatibility Class I Alleles

Genome-Wide DNA Methylation Association Study of Hand Osteoarthritis

A Rare Coding Allele in IFIH1 is Protective for Psoriatic Arthritis