ACR Meeting Abstracts

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Abstracts tagged "genetics"

  • Abstract Number: 1581 • ACR Convergence 2021

    Genetic Effects on the Transition from Hyperuricemia to Gout

    Nicholas Sumpter1, Riku Takei1, Richard Reynolds1 and Tony Merriman2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Dunedin, New Zealand

    Background/Purpose: There is clear evidence of genetic control of hyperuricemia resulting in increased gout risk, however genetic control of the transition from hyperuricemia to gout…
  • Abstract Number: 0576 • ACR Convergence 2021

    Associations of the MUC5B Promoter Variant with Timing of Articular Diagnosis and Interstitial Lung Disease in Rheumatoid Arthritis

    Gregory McDermott1, Ritu Gill2, Staci Gagne3, Suzanne Byrne3, Weixing Huang3, Jing Cui4, Lauren Prisco5, Alessandra Zaccardelli3, Lily Martin3, Nancy Shadick6, Paul Dellaripa3, Tracy Doyle7 and Jeffrey Sparks3, 1Brigham and Women's Hospital, Brookline, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham Women's Hospital, Boston, MA, 5Brigham and Women's Hospital, Pound Ridge, MA, 6Brigham & Women's Hospital, Boston, MA, 7Brigham and Women's Hospital, West Roxbury, MA

    Background/Purpose: The common promoter variant of MUC5B (G >T, rs35705950) is associated with increased mucin 5B production in lung parenchyma and is an established genetic…
  • Abstract Number: 1658 • ACR Convergence 2021

    Risk of Other Autoimmune Conditions Among Relatives of Patients with Rheumatoid Arthritis

    Katherine Liao1, Thany Seyok1 and Lisa Cannon-Albright2, 1Brigham and Women's Hospital, Boston, MA, 2University of Utah School of Medicine, Salt Lake City, UT

    Background/Purpose: Autoimmune conditions appear to cluster in families, as may be expected by shared genetic risk factors in conditions such as rheumatoid arthritis (RA), autoimmune…
  • Abstract Number: 0669 • ACR Convergence 2021

    Early-Onset Gout (EOG) Patients Are an Important and Recalcitrant Phenotype Warranting Further Investigation: A Systematic Review

    Anthony Amatucci1, Brian LaMoreaux2 and David Bulbin3, 1Horizon Therapeutics, West Orange, NJ, 2Horizon Therapeutics plc, Deerfield, IL, 3Geisinger Health System, Danville, PA

    Background/Purpose: Data suggests that the number of patients with early-onset gout (EOG), defined as patients under the age of 40 years, is increasing1. There is…
  • Abstract Number: 1928 • ACR Convergence 2021

    In Vitro and In Vivo Evidence for DOCK8 as a Risk Allele for Cytokine Storm Syndrome, Including COVID-19 and MIS-C

    Randy Cron1, Mingce Zhang1, Niansheng Chu2, Devin Absher3, John Bridges1, Amanda Schnell1, Anshul Vagrecha4, Shannon Lozinsky4, Suchitra Acharya4, Carolyn Levy4, Winn Chatham1 and Edward Behrens2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania, Philadelphia, PA, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL, 4Hofstra/Northwell School of Medicine, Hempstead, NY

    Background/Purpose: Cytokine storm syndromes (CSS) are frequently fatal complications of a variety of oncologic, rheumatic, and infectious diseases. Many patients with CSS possess heterozygous missense…
  • Abstract Number: 0672 • ACR Convergence 2021

    Does Obesity Affect Gout Risk Differently Among Genetically Predisposed Individuals?: Sex-Specific Prospective Cohort Study Findings over >32 Years

    Chio Yokose1, Natalie McCormick2, Na Lu3, Amit Joshi2 and Hyon K. Choi4, 1Massachusetts General Hospital, Waltham, MA, 2Massachusetts General Hospital, Boston, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Two recent analyses of the Global Burden of Disease Study reported on the rising global burden of gout (Safiri A&R 2020, Xia Rheumatology 2020).…
  • Abstract Number: 0017 • ACR Convergence 2021

    Lessons Learnt from Associations Between Anti-modified Protein Antibodies and Risk Factors: Human Leukocyte Antigen – Shared Epitope Alleles Solely Associate with Anti-citrullinated Protein Antibodies

    Tineke J van wesemael, Annemarie L. Dorjee, Tom WJ Huizinga, Annette H.M van der Helm-van Mil, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of auto-antibodies to post translationally modified proteins (anti-modified protein antibodies (AMPA)): anti-citrullinated protein antibodies (ACPA), anti-carbamylated…
  • Abstract Number: 0776 • ACR Convergence 2021

    Genetics of Neonatal Lupus Erythematosus Risk and Specific Manifestations

    Melissa Misztal1, Fangming Liao2, Talia Diaz2, Zeynep Baskurt2, JingJing Cao2, Daniela Dominguez2, Deborah Levy2, Andrea Knight3 and Linda Hiraki2, 1The Hospital for Sick Children, Oakville, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Neonatal lupus erythematosus (NLE) is a passively acquired autoimmune disease in infants, secondary to the transplacental passage of maternal autoantibodies against Ro and/or La.…
  • Abstract Number: 0326 • ACR Convergence 2021

    Apolipoprotein L1 (APOL1) in African-American SLE: Frequency and Clinical Associations

    Michelle Petri1, Romy Kallas2, Jessica Li3, Laurence Magder4 and Daniel Goldman1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Lankenau Medical Center, Lankenau, PA, 3Johns Hopkins University, Baltimore, MD, 4University of Maryland, Baltimore, Baltimore, MD

    Background/Purpose: The APOL1 gene is implicated in induction of TLR3 agonists and interferons as well as in autophagy. Two genetic variants, G1 (2 single nucleotide…
  • Abstract Number: 0783 • ACR Convergence 2021

    Transmission Disequilibrium Testing Meets Next Generation Sequencing: Applying TDT to Whole Genome Data in Childhood-Onset Systemic Lupus Erythematosus

    Kathleen Vazzana1, Anthony Musolf2, Joan Bailey-Wilson3, Zuoming Deng3, Mariana Kaplan3 and Laura Lewandowski2, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)/Children's National Hospital, Washington, DC, 2NIAMS, NIH, Rockville, MD, 3National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that is more severe in children than adults. Due to aggressive disease in childhood-onset SLE…
  • Abstract Number: 0377 • ACR Convergence 2021

    The Prevalence of Inflammatory Back Pain and HLA-B27 in a Large Population-Based Cohort in the Netherlands

    Stan Kieskamp, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma, Ilja Nolte and Anneke Spoorenberg, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Chronic low back pain (CLBP; back pain >3 months) with onset at age < 45 and inflammatory back pain (IBP) are regarded as early…
  • Abstract Number: 0884 • ACR Convergence 2021

    Genetics of Longitudinal Disease Activity in Adults with Systemic Lupus Erythematosus

    Linda Hiraki1, Fangming Liao1, Dafna Gladman2, Ker-Ai Lee3, Zahi Touma4, Joan Wither5, Richard Cook3 and Murray Urowitz6, 1The Hospital for Sick Children, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Department of Statistics and Actuarial Sciences, University of Waterloo, Waterloo, ON, Canada, 4University of Toronto, Mississauga, ON, Canada, 5University Health Network, Toronto, ON, Canada, 6Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, ON, Canada

    Background/Purpose: Genetics and gene expression has been shown to correlate with systemic lupus erythematosus (SLE) disease severity. Our aim was to identify genetic risk loci…
  • Abstract Number: 0372 • ACR Convergence 2020

    Tumor Necrosis Factor-α Receptor 2 Polymorphisms and Response to TNF Inhibitor Therapy in Patients with Psoriatic Arthritis

    Sarah Rasheed1, MacKenzie Dunlap1, Jennifer Harvey1, Connery Brennan1, Yuxuan Jin2, Unnikrishnan Chandrasekharan3 and M. Elaine Husni2, 1Cleveland Clinic Foundation, Cleveland, 2Cleveland Clinic, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) have significantly improved the prognosis of patients with psoriatic arthritis (PsA); however, approximately 40% of patients do not achieve…
  • Abstract Number: 1667 • ACR Convergence 2020

    Development of Autoimmune Diseases and HLA Associations in Children with Neonatal Lupus and Their Unaffected Siblings

    Amit Saxena1, Aaron Garza Romero2, Daniel Gratch3, Peter Izmirly4, Hannah Ainsworth5, Miranda Marion5, Carl Langefeld6, Robert Clancy7 and Jill Buyon8, 1NYU School of Medicine, New York, 2Gonzaba Medical Group, San Antonio, 3NYU Langone Health, New York, 4Department of Medicine, New York University School of Medicine, New York, NY, 5Wake Forest School of Medicine, Winston-Salem, 6Wake Forest School of Medicine, Winston Salem, NC, 7New York University School of Medicine, New York, NY, 8Department of Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies with major manifestations being congenital heart block…
  • Abstract Number: 0426 • ACR Convergence 2020

    T-Cell Receptor (TCR) Sequencing Reveals Decreased Diversity and Clonotypic Expansion of T-cells in Relapsing Polychondritis (RP)

    Emily Rominger1, Sufia Bakshi2, Emily Rose3, Marcela Ferrada3, Peter C. Grayson4, Robert Colbert5 and Keith Sikora6, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 2National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, 5Pediatric Clinical Trials Unit and Office of Clinical Director, NIAMS, NIH, Bethesda, MD, 6National Institutes of Health Clinical Center, Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a rare, systemic inflammatory disease characterized by recurrent inflammation of cartilaginous structures, including the nose/ears, joints, and trachea. The etiology of…
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