Abstracts tagged "genetics and vasculitis"

Abstract Number: 2343 • 2017 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Suggests the HLA Class II Region As the Major Susceptibility Locus for IgA Vasculitis
Raquel López-Mejías¹, Sara Remuzgo-Martínez¹, Fernanda Genre¹, Francisco David Carmona², Santos Castañeda³, Belén Sevilla Pérez⁴, Norberto Ortego Centeno⁴, Javier Llorca⁵, Begoña Ubilla¹, Veronica Mijares¹, Trinitario Pina⁶, Jose A. Miranda-Filloy⁷, Antonio Navas Parejo⁸, Diego Argila⁹, Maximiliano Aragües¹⁰, Esteban Rubio-Romero¹¹, Manuel Leon Luque¹², Juan María Blanco Madrigal¹³, Eva Galindez-Agirregoikoa¹³, David Jayne¹⁴, Ricardo Blanco¹, Javier Martin¹⁵ and Miguel Angel González-Gay¹⁶, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Departamento de Genética e Instituto de Biotecnología, University of Granada, Granada, Spain, ³Hospital Universitario La Princesa. IIS-IP. Madrid. Spain, Madrid, Spain, ⁴Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ⁵Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁶Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁷Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, ⁸Nephrology Department, Hospital Universitario San Cecilio, Granada, Spain, ⁹Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, ¹⁰Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, MAdrid, Spain, ¹¹Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, ¹²Rheumatology Department,Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹³Rheumatology Division, Hospital Universitario de Basurto, Bilbao, Spain, ¹⁴Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ¹⁵Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, ¹⁶Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Immunoglobulin-A (IgA) vasculitis, also known as Henoch-Schöenlein purpura (HSP), is the most common type of primary small-sized blood vessel leukocytoclastic vasculitis in children, although…
Abstract Number: 3229 • 2015 ACR/ARHP Annual Meeting
Using Exome Sequencing to Identify Novel Genetic Associations with Granulomatosis with Polyangiitis Susceptibility
Angel C.Y. Mak¹, Paul L.F. Tang², Gang Xie³, Pui-Yan Kwok², Paul A. Monach⁴, Simon Carette³, David Cuthbertson⁵, Gary S. Hoffman⁶, Nader A. Khalidi⁷, Curry L. Koening⁸, Carol A. Langford⁶, Carol A. McAlear⁹, Larry W. Moreland¹⁰, Christian Pagnoux³, Philip Seo¹¹, Ulrich Specks¹², Antoine G. Sreih¹³, Steven R. Ytterberg¹⁴, Peter A. Merkel¹⁵, Katherine A. Siminovitch³, Sharon A. Chung¹⁶ and Vasculitis Clinical Research Consortium, ¹Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, ²Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, ³Mount Sinai Hospital, Toronto, ON, Canada, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁶Rheumatology, Cleveland Clinic, Cleveland, OH, ⁷McMaster University, Hamilton, ON, Canada, ⁸Rheumatology, University of Utah, Salt Lake City, UT, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹³Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁵Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁶Russell/Englemen Rheumatology Research Center, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Previous genome-wide association studies of granulomatosis with polyangiitis (Wegener’s, GPA) identified common genetic variants associated with susceptibility to GPA. However, since GPA is a…