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Abstracts tagged "genetics and tophaceous gout"

  • Abstract Number: 2839 • 2019 ACR/ARP Annual Meeting

    Association of a Gout Polygenic Risk Score with Disease Severity Phenotypes Amongst Caucasian Gout Patients in Three Independent Cohorts

    Nicholas Sumpter1, Tony Merriman 2, Richard Reynolds 3, Abhishek Abhishek 4, Mariano Andrés 5, Nicola Dalbeth 6, Michael Doherty 4, Lennart Jacobsson 7, Matthijs Janssen 8, Tim Jansen 9, Leo Joosten 10, Meliha Kapetanovic 11, Frédéric Lioté 12, Hirotaka Matsuo 13, Geraldine McCarthy 14, Fernando Perez-Ruiz 15, Philip Riches 16, Pascal Richette 17, Edward Roddy 18, Blanka Stiburkova 19, Alex So 20, Lisa Stamp 21, Anne-Kathrin Tausche 22, Rosa Torres-Jimenez 23 and Till Uhlig 24, 1University of Otago, Birmingham, 2University of Otago, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, 4The University of Nottingham, Nottingham, United Kingdom, 5Hospital General Universitario de Alicante, Alicante, Spain, 6University of Auckland, Auckland, New Zealand, 7Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden, 8Rijnstate Hospital, Arnhem, Netherlands, 9Viecuri MC, Venlo, Netherlands, 10Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, Netherlands, 11Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Section of Rheumatology, Lund and Malmö, Sweden, Lund, Sweden, 12Rheumatology Department, Lariboisiere Hospital, AP-HP, Paris, France, Paris, France, 13National Defense Medical College, Tokorozawa, Japan, 14University College Dublin, Dublin, Ireland, 15Hospital de Cruces, Vizcaya, Spain, 16The University of Edinburgh, Edinburgh, United Kingdom, 17Department of Rheumatology, AP-HP Lariboisiere Hospital, Paris, France, 18Research Institute for Primary Care and Health Sciences and Keele Clinical Trials Unit, Keele, United Kingdom, 19Institute of Rheumatology; Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic, 20Universite de Lausanne, Lausanne, Switzerland, 21University of Otago, Christchurch, Christchurch, Canterbury, New Zealand, 22Universitatsklinikum Dresden, Dresden, Germany, 23Instituto de Investigación Sanitaria del Hospital Universitario La Paz, Madrid, Spain, 24Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway

    Background/Purpose: This study aimed to determine whether a polygenic risk score (PRS) based on gout-associated genetic variants is associated with gout disease severity phenotypes such…
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