Abstracts tagged "genetics and spondylarthritis"

Abstract Number: 1505 • 2017 ACR/ARHP Annual Meeting
Gender Bias in the Inheritance of Ankylosing Spondylitis
Karim Doughem¹, Michael Weisman², Lianne S. Gensler³, Mohammad H. Rahbar⁴, MinJae Lee⁴, Laura A. Diekman⁵, Matt Brown⁶, Michael Ward⁷ and John D. Reveille⁵, ¹Rheumatology, The University of Texas-McGovern Medical School, Houston, TX, ²Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ³Medicine/Rheumatology, UCSF, San Francisco, CA, ⁴Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁵Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ⁶Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁷NIH/NIAMS, Bethesda, MD
Background/Purpose: There are few studies of the heritability of ankylosing spondylitis (AS) in families, a disease where hereditary factors play a dominant role in disease…
Abstract Number: 2489 • 2013 ACR/ARHP Annual Meeting
Spondyloarthritis-Associated Polymorphisms Of ERAP1 Are Correlated With Gene Expression, Protein Level and Enzymatic Activity Of The Amino-Peptidase
Félicie Costantino¹, Alice Talpin², Irini Evnouchidou³, Amir Kadi², Roula Said-Nahal⁴, Ariane Leboime⁵, Nelly Bonilla⁶, Franck Letourneur⁶, Tifenn Leturcq², Zeyna Ka², Peter van Endert³, Henri-Jean Garchon^2,7, Gilles Chiocchia^8,9 and Maxime A. Breban^2,7, ¹INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ²Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ³INSERM U1013 - Université Paris Descartes - Sorbonne Paris Cité, Paris, France, ⁴Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁵Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁶INSERM U1016, Cochin Institute, Paris, France, ⁷Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁸Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France, ⁹Université Versailles-Saint Quentin, Montigny le Bretonneux, France
Background/Purpose: Endoplasmic reticulum aminopeptidase 1 (ERAP1) exerts a central role in antigen presentation making it an attractive candidate gene for inflammatory diseases. Several polymorphisms in…

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