Abstracts tagged "genetics and sex bias"

Abstract Number: 648 • 2015 ACR/ARHP Annual Meeting
Klinefelter’s Syndrome (47,XXY) Among Men with Sjögren’s Syndrome
Valerie M Harris¹, Joshua Cavett², Biji Kurien³, Ke Liu⁴, Kristi A. Koelsch⁵, Lida Radfar⁶, David M. Lewis⁷, Donald U. Stone⁸, Shibo Li⁹, Barbara Segal¹⁰, Daniel J Wallace¹¹, Michael H. Weisman¹², Jennifer A. Kelly¹³, Marta Alarcon-Riquelme¹⁴, Bernado Pons-Estel¹⁵, Roland Jonsson¹⁶, Xianglan Lu⁹, Jacques Gottenberg¹⁷, Juan-Manuel Anaya¹⁸, Deborah S. Cunninghame-Graham¹⁹, Edward C. Keystone²⁰, Andrew J.W. Huang²¹, Michael T. Brennan²², Pamela Hughes²³, G Illei²⁴, Corinne Miceli²⁵, VP Bykerk²⁶, Gideon Hirschfield²⁷, Gang Xie²⁸, Wan-Fai Ng²⁹, Gunnel Nordmark³⁰, Per Eriksson³¹, Roald Omdal³², Nelson L. Rhodus³³, Maureen Rischmueller³⁴, Michael D. Rohrer³⁵, Marie Wahren-Herlenius³⁶, Torsten Witte³⁷, Xavier Mariette³⁸, Christopher Lessard³⁹, John B. Harley⁴⁰, Kathy L. Sivils³⁹ and Robert Hal Scofield⁴¹, ¹Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴3333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, ⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ⁷College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁹Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Rheumatology, Univ of Minnesota, Minneapolis, MN, ¹¹Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹³Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁴Arthritis & Clinical Immunology, Oklahoma Medical REsearch Foundtion, Oklahoma City, OK, ¹⁵Hospital Provincial de Rosario, Rosario, Argentina, ¹⁶Broegelmann research laboratory, Bergen, Norway, ¹⁷Hautepierre, Strasbourg, France, ¹⁸Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, ¹⁹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁰Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ²¹Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, ²²Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ²³Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁴Sjögren's Clinic, NIDCR/NIH, Bethesda, MD, ²⁵Rheumatology, PARIS, France, ²⁶University of Toronto, Toronto, ON, Canada, ²⁷Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²⁸Mount Sinai Hospital, Toronto, ON, Canada, ²⁹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³⁰Medical Sciences, Uppsala University, Uppsala, Sweden, ³¹University Hospital, Rheumatology clinic, Linköping, Sweden, ³²Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, ³³Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁴Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ³⁵Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁶Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, ³⁷Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ³⁸Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ³⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴¹Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Primary Sjögren’s syndrome (pSS) has a strong female bias of greater than 10 to 1. This difference in risk of disease between the sexes…

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