Abstracts tagged "genetics and juvenile idiopathic arthritis (JIA)"

Abstract Number: 1969 • 2018 ACR/ARHP Annual Meeting
GENE Enhancers Associated with an Increase Risk of Developing JIA Fail to DOWN Regulate RUNX1 after CELL Stimulation
Annie Yarwood¹, Kate Duffus², Christopher Taylor³, Amanda McGovern², Stephen Eyre⁴ and Wendy Thomson⁵, ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ³University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: In recent years there have been tremendous strides in determining the genetic component of complex diseases, not least in Juvenile Idiopathic Arthritis (JIA). We…
Abstract Number: 168 • 2017 ACR/ARHP Annual Meeting
Identification of Novel Susceptibility Loci in a Large UK Cohort of Juvenile Idiopathic Arthritis (JIA) Cases
Samantha Smith¹, John Bowes¹, Joanna Cobb², Anne Hinks¹, Sunil Sampath¹, Annie Yarwood¹, Lucy R Wedderburn³, Kimme L. Hyrich⁴ and Wendy Thomson¹, ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, Manchester, United Kingdom, ³3Arthritis Research UK Centre for Adolescent Rheumatology, UCL GOS Institute of Child Health, University College London, London, United Kingdom, ⁴Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a group of chronic arthropathies of unknown cause affecting children under 16yrs, and is the most common childhood inflammatory…
Abstract Number: 18 • 2017 Pediatric Rheumatology Symposium
Bridging the gap between GWAS and mechanism in juvenile idiopathic arthritis using a novel high-throughput experimental screen
Gang Li¹, Marta Martinez-Bonet¹, Di Wu², Jing Cui³ and Peter A. Nigrovic^1,4, ¹Brigham and Women's Hospital, Boston, MA, ²University of North Carolina, Chapel Hill, Chapel Hill, NC, ³Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Division of Immunology, Boston Children's Hospital, Boston, MA
Background/Purpose: Genome wide association studies (GWAS) have identified 27 non-HLA loci that convey risk for oligoarticular and seronegative polyarticular JIA. Most associated haplotypes bear no…

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