Abstracts tagged "Genetics and gout"

Abstract Number: 2221 • 2018 ACR/ARHP Annual Meeting
Systematic Genetic Analysis of Early-Onset Gout: ABCG2 141K Is the Strongest Predictor
Faseeh Zaidi¹, Amanda Phipps-Green², Anne-Kathrin Tausche³, Alexander So⁴, Philip Riches⁵, Mariano Andres⁶, Fernando Perez-Ruiz⁷, Michael Doherty⁸, Matthijs Janssen⁹, Leo .A.B. Joosten¹⁰, Tim Jansen¹¹, Fina Kurreeman¹², Rosa Torres¹³, Geraldine M. McCarthy¹⁴, Jeffrey Miner¹⁵, Lisa K. Stamp¹⁶, Tony R. Merriman² and Nicola Dalbeth¹, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ⁴University of Lausanne, Lausanne, Switzerland, ⁵University of Edinburgh, Edinburgh, United Kingdom, ⁶Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ⁷BioCruces Health Research Institute, Barakaldo, Spain, ⁸The University of Nottingham, Nottingham, United Kingdom, ⁹Rheumatology Dept, Rijnstate Hospital, Arnhem, Netherlands, ¹⁰Radboud University Medical Center, Nijmegen, Netherlands, ¹¹VieCuri Medical Center, Venlo, Netherlands, ¹²Leiden University Medical Centre, Leiden, Netherlands, ¹³La Paz University Hospital, Madrid, Spain, ¹⁴Mater Misericordiae University Hospital, Dublin, Ireland, ¹⁵Formerly Ardea Biosciences, San Diego, CA, ¹⁶University of Otago, Christchurch, New Zealand
Background/Purpose: Although increasing age is an important risk factor for development of gout, disease can develop in younger people. The aim of this study was…
Abstract Number: 2224 • 2018 ACR/ARHP Annual Meeting
Interactions between Serum Urate-Associated Genetic Variants and Sex on Gout Risk in a European Population
Ravi K. Narang¹, Ruth Topless², Murray Cadzow³, Gregory Gamble⁴, Lisa K. Stamp⁵, Tony R. Merriman³ and Nicola Dalbeth⁶, ¹Bone and Joint Research Group, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³University of Otago, Dunedin, New Zealand, ⁴Department of Medicine, University of Auckland, Auckland, New Zealand, ⁵University of Otago, Christchurch, New Zealand, ⁶Department of Medicine, Faculty of Medical and Health Sciences., University of Auckland, Auckland, New Zealand
Background/Purpose: Sex-specific differences in the effect size of genetic variants on serum urate levels have been described, with SLC2A9 variants having a greater influence on…
Abstract Number: 2231 • 2018 ACR/ARHP Annual Meeting
An Ancestral-Specific Interaction of TRIM46 with a Past-History of Smoking May Influence Gout Risk
Niamh Fanning¹, Tony R. Merriman², Amanda Phipps-Green², John Pearson³, Ruth Topless², Murray Cadzow², Douglas White⁴, Nicola Dalbeth⁵ and Lisa K. Stamp⁶, ¹Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, Christchurch, New Zealand, ⁴Department of Rheumatology, Waikato Clinical School, Hamilton, New Zealand, ⁵University of Auckland, Auckland, New Zealand, ⁶University of Otago, Christchurch, New Zealand
Background/Purpose: Gout is caused by an interplay of genetic and environmental factors. Epidemiological and prospective studies suggest that current-smoking may be protective for developing gout…
Abstract Number: 2960 • 2014 ACR/ARHP Annual Meeting
Urate Genetic Loci and the Risk of Incident Cases of Confirmed Gout in Two Prospective Cohort Studies
Hyon K. Choi¹, Gary Curhan², Ying Bao³, Eli A. Stahl⁴, Peter Kraft⁵, Robert M. Plenge⁶, Yuqing Zhang¹ and Tony R. Merriman⁷, ¹Boston University School of Medicine, Boston, MA, ²German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ³Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Department of Biochemistry, University of Otago, Dunedin, New Zealand
Background: Gout is the most common inflammatory arthritis and is caused by hyperuricemia. The Global Urate Genetics Consortium (GUGC) has recently validated 28 SNP associations…

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