Abstracts tagged "genetics and genomics"

Abstract Number: 836 • 2018 ACR/ARHP Annual Meeting
Genetic Risk Score Prediction in Ankylosing Spondylitis
Zhixiu Li¹, Erika De Guzman¹, Jessica Harris¹, Nurullah Akkoc², Mahdi Mahmoudi³, Maxime Breban⁴, Chung-Tei Chou⁵, Michael Weisman⁶, Lianne S. Gensler⁷, Michael Ward⁸, Mohammad H. Rahbar⁹, Laura A. Diekman¹⁰, Tae-Hwan Kim¹¹, Paul Leo¹, John D. Reveille¹⁰, Paul Wordsworth¹², Matthew Brown¹ and Huji Xu¹³, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²Rheumatology, İzmir, Turkey, İzmir, Turkey, ³Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran (Islamic Republic of), ⁴Hôpital Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne, France, Boulogne, France, ⁵Division of Allergy-Immunology-Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, USA, Los Angeles, CA, ⁷University of California San Francisco, San Francisco, CA, ⁸National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁹Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ¹⁰Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ¹¹Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South), ¹²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, United Kingdom, ¹³School of Clinical Medicine, Tsinghua University, Beijing, China, Beijing, China
Background/Purpose: The diagnosis of ankylosing spondylitis (AS) is delayed by on average 8–11 years after the onset of symptoms, and there is increasing evidence that…
Abstract Number: 670 • 2016 ACR/ARHP Annual Meeting
Identification and Characterization of Sjogren’s Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci
Michelle L. Joachims¹, Indra Adrianto², Audrey Johnston², John Ice², Astrid Rasmussen³, Simon Bowman⁴, David M. Lewis⁵, Lida Radfar⁶, Roald Omdal⁷, Marie Wahren-Herlenius⁸, Ilias Alevizos⁹, Torsten Witte¹⁰, Roland Jonsson^11,12, Maureen Rischmueller^13,14, Patrick M. Gaffney², Judith A. James^2,15,16, Lars Rönnblom¹⁷, Elke Theander¹⁸, Nelson L. Rhodus¹⁹, Barbara M. Segal²⁰, R. Hal Scofield^2,16,21, Courtney G. Montgomery², Xavier Mariette²², Wan-Fai Ng²³, Gunnel Nordmark²⁴, Kathy L. Sivils^2,15 and Christopher J. Lessard^2,15, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ⁴Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁵Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁹Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, ¹⁰Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹¹Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ¹³Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ¹⁴Rheumatology, University of Adelaide, Adelaide, Australia, ¹⁵Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁶Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ¹⁸Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, ¹⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁰Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ²¹US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ²²Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ²³Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune-mediated disease with hallmark features of dry eyes/mouth and autoantibodies. Genetic susceptibility to SS involves many loci, including the…
Abstract Number: 3230 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Study Identifies Novel Sjögren’s Syndrome Risk Loci in the Regions of NAB1, TYK2, and PTTG1-mir146a
Christopher J. Lessard¹, Indra Adrianto¹, John Ice¹, Astrid Rasmussen², Kiely Grundahl³, Jennifer A. Kelly⁴, R. Hal Scofield¹, Simon Bowman⁵, Susan Lester⁶, Per Eriksson⁷, Maija-Leena Eloranta⁸, Johan G. Brun⁹, Lasse G. Goransson¹⁰, Erna Harboe¹⁰, Marika Kvarnström¹¹, Michael T. Brennan¹², James Chodosh¹³, Raj Gopalakrishnan¹⁴, Andrew J.W. Huang¹⁵, Pamela Hughes¹⁶, David M. Lewis¹⁷, Michael D. Rohrer¹⁸, Donald U. Stone¹⁹, Nelson L. Rhodus²⁰, Barbara M. Segal²¹, Lida Radfar²², A. Darise Farris²³, Joel M. Guthridge²⁴, Patrick M. Gaffney¹, Judith A. James¹, John B. Harley²⁵, Lars Rönnblom⁸, Juan-Manuel Anaya²⁶, Deborah S. Cunninghame-Graham²⁷, Timothy J. Vyse²⁸, Ilias Alevizos²⁹, Xavier Mariette³⁰, Roald Omdal¹⁰, Marie Wahren-Herlenius³¹, Torsten Witte³², Roland Jonsson³³, Maureen Rischmueller³⁴, Lindsey A. Criswell³⁵, Courtney G. Montgomery¹, Wan-Fai Ng³⁶, Gunnel Nordmark³⁷ and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁶Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia, ⁷University Hospital, Rheumatology clinic, Linköping, Sweden, ⁸Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ⁹Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ¹⁰Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹¹Karolinska Institutet, Stockholm, Sweden, ¹²Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ¹³Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁵Washington University,, St Louis, MO, ¹⁶Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁷Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ¹⁸Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁹Dean McGee Eye Institute, Oklahoma City, OK, ²⁰Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²¹Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ²²Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ²³Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ²⁴Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁵Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ²⁶Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, ²⁷Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁸Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, ²⁹Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, ³⁰Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ³¹Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ³²Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ³³Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ³⁴Rheumatology, University of Adelaide, Adelaide, Australia, ³⁵Division of Rheumatology, UCSF, San Francisco, CA, ³⁶Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³⁷Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with both environmental and genetic factors contributing to pathophysiology. The goal of this genome-wide association study…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].