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Abstracts tagged "genetics"

  • Abstract Number: 2679 • ACR Convergence 2025

    Early-Life Nutrition and Gene-Environment Interactions Influencing Juvenile Idiopathic Arthritis Risk: Results from a Pregnancy Cohort

    Vilde Øverlien Dåstøl1, Ida Henriette Caspersen2, Kristine Løkås Haftorn3, Sigrid Hestetun4, Siri Eldevik Håberg5, Karen H. Costenbader6, Marin Strøm7, Sjurdur Frodi Olsen8, Anne Lise Brantsæter9, Ketil Størdal10 and Helga Sanner1, 1Oslo University Hospital, Oslo, Norway, 2Norwegian Institute of Public Health, Centre for Fertility and Health/Oslo University Hospital, Oslo, Norway, 3Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 4Oslo University Hospital, Department of Rheumatology/University of Oslo, Oslo, Norway, 5Norwegian Institute of Public Health, Centre for Fertility and Health/University of Bergen, Oslo, Norway, 6Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 7Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, 8Statens Serum Institut,Biobank, congenital disorders, and vaccines preparedness/Harvard T.H. Chan School of Public Health, Copenhagen, Denmark, 9Norwegian Institute of Public Health, Department of Food Safety and Centre for Sustainable Diets, Oslo, Norway, 10Oslo University Hospital, Department of Pediatric and Adolescent Medicine/University of Oslo, Oslo, Norway

    Background/Purpose: Early-life nutrition may influence the risk of immune-mediated diseases like juvenile idiopathic arthritis (JIA). The benefits of breastfeeding are well established, but findings related…
  • Abstract Number: 1423 • ACR Convergence 2025

    Genetic and Cytokine Correlates in Ankylosing Spondylitis: rs27038 polymorphism of ERAP1 gene and IL-17 Interactions : A Case-Control Study

    Meghna Gavali1, Husna Fatima2, Bhavya Sirivelu3, Nishanth S3 and Noorjahan M3, 1nizam's institute of medical sciences ,Hyderabad, Hyderabad, Telangana, India, 2Nizami Institute of Medical Sciences, Hyderabad, Telangana, India, 3Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India

    Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disorder primarily affecting the axial skeleton and associated with HLA-B27. Non-HLA genes, including ERAP1 (Endoplasmic Reticulum Aminopeptidase…
  • Abstract Number: 0104 • ACR Convergence 2025

    Dissecting the Genetic and Functional Association of CARD9 with Axial Spondyloarthritis

    Félicie Costantino1, Eva Frison2, Andrew Brown3, Carla Cohen3, Manon Jacoutot4, Gabriele Migliorini3, roula Said-Nahal5, Giuseppe Scozzafava3, Paul Bowness6, Paul Wordsworth6, Henri-Jean Garchon2, Simon Glatigny4, Maxime Breban7 and Julian Knight6, 1Department of Rheumatology, Ambroise Paré Hospital, AP-HP, Paris, France and Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Montigny-Le-Bretonneux, France, 2Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Montigny le Bretonneux, France, 3NIHR Oxford Biomedical Research Centre, University of Oxford, Centre for Human Genetics, Oxford, United Kingdom, 4Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Montigny-Le-Bretonneux, France, 5Department of Rheumatology, Ambroise Paré Hospital, AP-HP, Paris, France and Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Boulogne-Billancourt, France, 6NIHR Oxford Biomedical Research Centre, University of Oxford, NDORMS, Oxford, United Kingdom, 7CHU Ambroise-Paré, Boulogne-Billancourt, France

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic immune-mediated inflammatory disease with strong genetic predisposition, driven by HLA-B27 and over 100 additional loci identified by genome-wide…
  • Abstract Number: 2666 • ACR Convergence 2025

    Rare TNFAIP3 Hypomorphic Variants are a Massively Underestimated Driver of Human Autoinflammatory Disease

    Danica Lee1, Urekha Karri2, Yiming Luo3, Kader Cetin Gedik4, Manuel Carpio Tumba5, Prabal Chhibbar6, Priyamvada Roy6, Guido Falduto7, Jishnu Das5 and Daniella Schwartz5, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2School of public health, Pittsburgh, PA, 3Columbia University, New York, NY, 4UPMC Children's Hospital of Pittsburgh/University of Pittsburgh, Pittsburgh, PA, 5University of Pittsburgh, Pittsburgh, PA, 6University of Pittsburgh School of Medicine, Pittsburgh, 7University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: TNFAIP3 encodes the ubiquitin editing enzyme A20, which inhibits multiple proinflammatory signaling pathways. Heterozygous germline mutations in TNFAIP3 cause the autoinflammatory disease Haploinsufficiency of…
  • Abstract Number: 1346 • ACR Convergence 2025

    Preliminary Result of Investigating the Response of Conventional Disease-Modifying Antirheumatic Drugs (cDMARDs) Associated SNPs: One Cohort Study

    YU Chen1, Chien-Sheng Wu2, Jacob Shujui Hsu3 and Pei-Lung Chen4, 1Division of Rheumatology, Allergy and Immunology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C. Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., New Taipei City, Taiwan (Republic of China), 2Division of Rheumatology, Allergy and Immunology, Far Eastern Memorial Hospital, New Taipei City, Taiwan, R.O.C., New Taipei city, Taiwan (Republic of China), 3Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., Taipei city, Taiwan (Republic of China), 4Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan, R.O.C., Taipei, Taiwan (Republic of China)

    Background/Purpose: Multiple Single-Nucleotide Polymorphisms (SNPs), including those in the methotrexate and azathioprine metabolic pathways, are associated with poor response to conventional disease-modifying anti-rheumatic drugs (cDMARDs)…
  • Abstract Number: 0103 • ACR Convergence 2025

    Common and Rare Variant Contributions to Familial Aggregation in Spondyloarthritis

    Félicie Costantino1, roula Said-Nahal2, Hendrick Mambu Mambueni3, Anne Boland4, Jean-François Deleuze4, Matthew Brown5, Henri-Jean Garchon3 and Maxime Breban6, 1Department of Rheumatology, Ambroise Paré Hospital, AP-HP, Paris, France and Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Montigny-Le-Bretonneux, France, 2Department of Rheumatology, Ambroise Paré Hospital, AP-HP, Paris, France and Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Boulogne-Billancourt, France, 3Infection & Inflammation, UMR 1173, Inserm, UVSQ/Université Paris Saclay, Montigny le Bretonneux, France, 4Centre National de Recherche en Génomique Humaine (CNRGH), Centre National de Recherche en Génomique Humaine (CNRGH), Université Paris-Saclay, CEA, Evry, France, 5Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, 6CHU Ambroise-Paré, Boulogne-Billancourt, France

    Background/Purpose: Spondyloarthritis (SpA) exhibits strong familial aggregation, with close relatives of patients having a significantly higher risk of developing the disease. This pattern might be…
  • Abstract Number: 2647 • ACR Convergence 2025

    Unlinked Paths to SLE: Divergent Associations of DNA Methylation and Polygenic Risk Scores with SLE Features

    Holme Vestin1, Nina Oparina1, Elisabeth Skoglund1, Maija-Leena Eloranta1, Martina Frodlund2, Iva Gunnarsson3, Chrisopher Sjöwall2, Elisabet Svenungsson4, Lars Rönnblom1, Juliana Imgenberg-Kreuz1 and Dag Leonard1, 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, 3Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Stockholms Lan, Sweden

    Background/Purpose: The aetiopathogenesis of SLE encompasses genetic and epigenetic factors, including hypomethylation of type I interferon (IFN) regulated genes (1) and the HLA-DRB1*03:01 haplotype, linked…
  • Abstract Number: 1301 • ACR Convergence 2025

    Prevalence, Clinical and Genetic Risk Factors, and Time to Cataract Development in Childhood-onset Systemic Lupus Erythematosus

    Sirikarn Tangcheewinsirikul1, Zhaoyu Ding2, Nicholas Chan3, Daniela Dominguez3, Andrea Knight4, Deborah Levy1, Lawrence Ng5, Earl Silverman1, Ruud Verstegen1 and Linda Hiraki1, 1The Hospital for Sick Children, Toronto, ON, Canada, 2SickKids Research Institute, Toronto, ON, Canada, 3The Hospital for Sick Children, Toronto, Canada, 4Hospital for Sick Children, Toronto, ON, Canada, 5The Hospital for Sick Children, Toronto, Canada, Toronto, ON, Canada

    Background/Purpose: Cataracts are a significant ocular complication in childhood-onset systemic lupus erythematosus (cSLE). This study aimed to assess the prevalence, time to cataract development, and…
  • Abstract Number: 0073 • ACR Convergence 2025

    HLA-DQA1*01:02 Is Associated With IgG Multi-Reactivity With Citrulline-Containing Type II Collagen Epitopes While HLA-DRB*04:01 Is Associated With More Private Reactivity With Citrulline-Containing IgG Epitopes In Rheumatoid Arthritis

    S. Janna Bashar1, Courtney Myhr1, Adam Titi1, Zihao Zheng1 and Miriam Shelef2, 1University of Wisconsin-Madison, Madison, 2University of Wisconsin-Madison, Madison, WI

    Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross-reactive binding to many antigens containing short motifs, or more private with…
  • Abstract Number: 2432 • ACR Convergence 2025

    Duffy Null Genotype and Autoantibodies Synergistically Contribute to Severe Leukopenia in Systemic Lupus Erythematosus

    valerie Lewis1, Faith Porter2, Victoria Nwankwo3, John Ice4, Joshua Cavett5 and R Hal Scofield1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Langston University, Langton, OK, 3Emory University, Atlanta, GA, 4OKC VA Healthcare System, Oklahoma City, OK, 5Oklahoma Medicar Research Foundtion, Oklahoma City

    Background/Purpose: Systemic lupus erythematosus (SLE) is a common, complex inflammatory autoimmune disease in which dysregulation of both innate and adaptive immune responses has been implicated…
  • Abstract Number: 1292 • ACR Convergence 2025

    Childhood-onset Behçet’s disease: HLA alleles role on diagnosis and treatment in a Latin American tertiary center

    Matheus França1, Thales Souza2, Ricardo Machado3, Vinicius Matias4, Sylvia Farhat3, Lia Steuer3, Luisa Forero3, Verena Balbi3, Nadia Emi Aikawa5, Katia Kozu3, Clovis Artur Silva6, Adriana Elias7 and Lucia Maria Campos8, 1Instituto da Criança e do Adolescente, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil, 2Faculdade de Medicina da Universidade de Brasilia, Brasilia, Distrito Federal, Brazil, 3Instituto da Criança e do Adolescente, Hospital das Clinicas, Sao Paulo, Sao Paulo, Brazil, 4Faculdade de Ciências Medicas da Santa Casa de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 5Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, São Paulo, Brazil, 6University of São Paulo, São Paulo, São Paulo, Brazil, 7Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clinicas, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil, 8Instituto da Criança e do Adolescente, São Paulo, São Paulo, Brazil

    Background/Purpose: Behçet’s disease (BD) is a rare pediatric vasculitis with limited epidemiological data in Latin America centers, especially in children where initial symptoms can be…
  • Abstract Number: 0047 • ACR Convergence 2025

    Monocyte Transcriptomic Signatures Uncover Potential Pathogenic Mechanisms of the APOL1 High Risk Genotype (HRG)

    Vishnuprabu Pandian1, Adebola Agboola1, Sivasubramanian ramani2, Christele Felix3, Andrra Nimoni3, Jasmin Divers4, Timothy Niewold5 and Ashira Blazer2, 1University of Maryland, Baltimore, Baltimore, Maryland, 2University of Maryland Baltimore, Baltimore, Maryland, 3Hospital for Special Surgery, New York, NY, 4NYU Grossman Long Island School of Medicine, New York, New York, 5Hospital for Special Surgery, New York, New York

    Background/Purpose: Compared to the low-risk genotype (LRG) the APOL1 high-risk genotype (HRG) confers an increased risk of end stage kidney disease among individuals with systemic…
  • Abstract Number: 2390 • ACR Convergence 2025

    SLE Genetic Risk Loci in the Context of Environmental Exposure: A Gene-Based Classification and Clinical Insight

    Nina Oparina1, Holme Vestin1, Sarah Reid1, Ahmne Sayadi1, Maija-Leena Eloranta1, Martina Frodlund2, Karoline Lerang3, Andreas Jönsen4, Øyvind Molberg3, Solbritt Rantapää-Dahlqvist5, Anna Rudin6, Chrisopher Sjöwall7, Anders Bengtsson4, Lars Rönnblom1 and Dag Leonard1, 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Linkoping, Sweden, 3Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 4Department of Clinical Sciences, Lund University, Lund, Sweden, 5Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 6Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden, 7Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden

    Background/Purpose: Growing evidence supports the role of chemical exposures as contributors to the development of Systemic lupus erythematosus (SLE)1. Several of the gene variants associated…
  • Abstract Number: 1221 • ACR Convergence 2025

    Oxytocin pathway gene BST1 polymorphism rs4273468 genotype GG is negatively associated with Fibromyalgia

    Zeeshan Ahmed1, Koshy Nithin Thomas2, Shivika Guleria3, Amita Aggarwal4 and Able Lawrence3, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 2Christian Medical College, Vellore, Tamil Nadu, India, 3SGPGIMS, Lucknow, Lucknow, Uttar Pradesh, India, 4Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Oxytocin, also known as love hormone, is important in contextual memory. Oxytocin secreting parvocellular neurons suppress pain through projections to brain and spinal cord…
  • Abstract Number: 0039 • ACR Convergence 2025

    Hemophagocytic Lymphohistiocytosis Gene Variants in Severe COVID-19 Cytokine Storm Syndrome

    randy Cron1, Abhishek Kamath1, Mingce Zhang1, Devin Abhser2, Lesley Jackson1 and Walter Winn Chatham3, 1University of Alabama at Birmingham, Birmingham, AL, 2Kaiser Permanente Research Bank, Oakland, CA, 3University of Nevada, Las Vegas, Las Vegas, NV

    Background/Purpose: Severe COVID-19 infection resulting in hospitalization shares features with frequently fatal cytokine storm syndromes (CSS), such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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