Abstracts tagged "Genetic Biomarkers"

Abstract Number: 132 • 2019 ACR/ARP Annual Meeting
Anti-phosphatidylserine/prothrombin Antibodies Confer a Distinctive Molecular Profile in Primary Antiphospholipid Syndrome Patients
Chary Lopez-Pedrera¹, Mª Ángeles Aguirre-Zamorano ², Laura Pérez-Sanchez ³, Alejandra Patiño-Trives ¹, Maria Luque-Tevar ¹, Alejandro Ibañez-Costa ¹, Ivan Arias de la Rosa ⁴, Maria del Carmen Abalos-Aguilera ¹, Lourdes Alacaide-Ruggiero ⁵, Rafaela Ortega ¹, Nuria Barbarroja ⁶, Eduardo Collantes-Estevez ⁴, Massimo Radin ⁷, Irene Cecchi ⁷, Savino Sciascia ⁸ and Carlos Perez-Sanchez ⁹, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³MIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁴University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁵University of Cordoba, Cordoba, Spain, ⁶University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, ⁷University of Turin, Turin, Italy, ⁸Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy, ⁹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain
Background/Purpose: The clinical significance of non-canonical anti-phosphatidylserine/prothrombin (aPS/PT) antibodies in antiphospholipid syndrome (APS) is still controversial. This study assessed the prevalence of aPS/PT antibodies, their association with…
Abstract Number: 737 • 2019 ACR/ARP Annual Meeting
The MUC5B Promoter Variant Does Not Predict Outcomes in Systemic Sclerosis-related Interstitial Lung Disease
Elizabeth Volkmann¹, Donald Tashkin ², Michael Roth ³, Ning Li ², Grace Kim ², Jonathan Goldin ², Maureen Mayes ⁴, Julio Charles ⁵, Philip Clements ², Daniel Furst ⁶, Dinesh Khanna ⁷, Robert Elashoff ² and Shervin Assassi ⁴, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ²University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ³University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ⁵University of Texas, Houston, Houston, ⁶University of California, Los Angeles, CA, ⁷Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor
Background/Purpose: Interstitial lung disease (ILD) affects the majority of patients with systemic sclerosis (SSc). The disease course of ILD varies among SSc patients and no…
Abstract Number: 1929 • 2019 ACR/ARP Annual Meeting
Identification and Validation of Transcriptional Genes Associated with Osteoporotic Vertebral Fractures by Microarray Study, in Community Elderly Women
Levi Jales Neto¹, Zofia Wicik ², Georgea Torres ¹, Liliam Takayama ¹, Neusa Lopes ¹, alexandre Pereira ¹ and Rosa Pereira ³, ¹University of Sao Paulo, Sao Paulo, Brazil, ²University of Sao Paulo, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Sao Paulo, Brazil
Background/Purpose: The pathogenesis of osteoporosis, a common disease with high morbidity1, comprises genetic and environmental factors2. Recent studies demonstrated that blood samples are a source…
Abstract Number: 896 • 2018 ACR/ARHP Annual Meeting
Pharmacogenomics Study of Predicting Response of TNF Blocker and Medical Image Progression in Chinese Han Ankylosing Spondylitis Population
Jing Liu¹, Weilin Pu¹, Qi Zhu², He Fan¹, Wei Wan³, Hejian Zou⁴, Xiaodong Zhou⁵, John D. Reveille⁶, Dongyi He² and Jiucun Wang¹, ¹State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, ²Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital, Shanghai, China, ³Division of Rheumatology, Changhai Hospital, Shanghai, China, ⁴Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ⁵Internal Medicine-Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁶McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: TNF blockers, have been widely used in immune-mediated diseases and many genetic variations predicting treatment response have been described. We applied previously published genetic…
Abstract Number: 917 • 2018 ACR/ARHP Annual Meeting
Type 1 Interferon Levels Correlates with Age of Diagnosis and Ethnicity in Systemic Lupus Erythematous
Majid Abedi¹, Lilian Borisov², Allison Doyle¹, Francisco Flores², June Fujimoto², Aviva Jacobs¹, Pramod Naranatt¹, Liuliu Pan², William Ricketts³, Jacob Spangler¹, Kristen Warren² and Robert Terbrueggen², ¹DxTerity, Rancho Domiquez, CA, ²DxTerity, Rancho Dominguez, CA, ³Clinical Operations, DxTerity, Rancho Domiquez, CA
Background/Purpose: Low cost, patient-administered, “from home” genomic tests for monitoring disease activity and therapy response could revolutionize treatment and management of Systemic Lupus Erythematous (SLE)…
Abstract Number: 1135 • 2018 ACR/ARHP Annual Meeting
Genome-Wide Meta-Analysis Identified Two Novel Variants Associated with Hallux Valgus
Liubov Arbeeva¹, Braxton Mitchell², Rebecca D. Jackson³, Michelle S. Yau⁴, Kathleen Ryan⁵, Yvonne M. Golightly⁶, Marian T. Hannan⁷, Amanda Nelson⁸, Joanne M. Jordan⁹ and Marc C. Hochberg², ¹TARC, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Medicine, University of Maryland, Baltimore, MD, ³Ohio State University, Columbus, OH, ⁴Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁵University of Maryland, Baltimore, MD, ⁶Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Institute for Aging Research, Hebrew SeniorLife & Harvard Medical School, Boston, MA, ⁸UNC School of Medicine, Chapel Hill, NC, ⁹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Hallux valgus (HV) is a common foot disorder that is highly heritable. A genome-wide association study (GWAS) conducted in 4,409 Caucasians from the Framingham…
Abstract Number: 1136 • 2018 ACR/ARHP Annual Meeting
Association of Mitochondrial DNA Haplotypes with Symptomatic Hand and Thumb Based Osteoarthritis and Hand OA Progression
Charles Eaton¹, Mary Roberts², Jeffrey B. Driban³, Ida Kristin Haugen⁴, Lena Franziska Schaefer⁵, Bing Lu⁶, Rebecca D. Jackson⁷, Marc C. Hochberg⁸, C. Kent Kwoh⁹, Francisco J Blanco¹⁰ and Timothy E. McAlindon¹¹, ¹Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Rheumatology, Tufts Medical Center, BOSTON, MA, ⁴Diakonhjemmet Hospital, Oslo, Norway, ⁵Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁷Ohio State University, Columbus, OH, ⁸School of Medicine, University of Maryland, Baltimore, MD, ⁹Medicine, Division of Rheumatology, University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, ¹⁰Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ¹¹Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Hand osteoarthritis (OA) can be a painful, disabling condition, with an increased prevalence in women, the elderly, and has a strong genetic component (hereditability…
Abstract Number: 1292 • 2018 ACR/ARHP Annual Meeting
HLA-B*58:01 Genotype and the Risk of Allopurinol-Associated Severe Cutaneous Adverse Reactions in a Predominately Black or African American Population with Advanced Chronic Kidney Disease
Sarah Ford¹, Pamela Kimball¹, Gaurav Gupta¹ and Nehal Shah², ¹Virginia Commonwealth University, Richmond, VA, ²Medicine/Rheumatology, Virginia Commonwealth University, Richmond, VA
Background/Purpose: Allopurinol is the first line urate lowering drug used for treatment of gout. Its most feared side effect includes development of hypersensitivity drug reactions…
Abstract Number: 1975 • 2018 ACR/ARHP Annual Meeting
Behcet’s Disease Lies in the “B” Holder. New Associations in Disease Susceptibility and Manifestations
Mohanad Elfishawi^1,2, Sally Elfishawi³, Ghada Mossallam³, Paul Norman⁴, Jill Hollenbach⁵, Maneesh Misra⁵, Gonzalo Montero Martin⁶, Helma de Bruin⁷, Leos Van de Pasch⁷, Erik Rozemuller⁷, Marcelo Fernandiz-Vina⁶, Adriana Abrudescu⁸ and Khaled Zaky⁹, ¹Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, NY, ²Rheumatology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt, ³Clinical pathology and Immunology laboatory, National Cancer Institute, Cairo University, Cairo, Egypt, ⁴Division of Personalized Medicine and Department of Immunology, University of Colorado School of Medicine, Denver, CO, ⁵Department of Neurology, University of California San Francisco, San Francisco, CA, ⁶Department of Pathology, Stanford University,School of medicine, Palo Alto, CA, ⁷GenDx, Utrecht, Netherlands, ⁸Internal Medicine and Rheumatology, Icahn School of Medicine at Mount Sinai, Queens Hospital center, NYC, NY, ⁹Rheumatology and Rehabilitation, Faculty of medicine, Al-Azhar University, Cairo, Egypt
Background/Purpose: Behçet’s disease is a multisystem disease affecting young adults with variable vessel vasculitis as its underlying pathology. Previous studies in Behçet’s disease linked it…
Abstract Number: 2119 • 2018 ACR/ARHP Annual Meeting
Association of the Variant Form of rs17408553 at Human Leukocyte Antigen-C Supports Evidence That Hypo-Responsive Natural Killer Cells Adversely Influence the Course of Nephritis
Robert M. Clancy¹, H. Michael Belmont¹, Peter M. Izmirly², Nicole Bornkamp³, Sarah Miller⁴, Matthew Poulin⁴, Liying Yan⁴, Jill P. Buyon¹ and Ellen M. Ginzler⁵, ¹NYU School of Medicine, New York, NY, ²Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY, ⁴EpigenDx, Hopkinton, MA, ⁵Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: In subjects with lupus nephritis (LN), tissue injury due to local immune activation involving persistently activated macrophages in the renal parenchyma is limited by…
Abstract Number: 2983 • 2018 ACR/ARHP Annual Meeting
The Changing Faces of Rheumatoid Arthritis Patients at Presentation: A 20-Year Study
Nathalie Carrier¹, Sophie Roux², Ariel Masetto², Artur J deBrum Fernandes³, Patrick Liang⁴, Meryem Maoui⁵ and Gilles Boire⁴, ¹Centre intégré universitaire de santé et de services sociaux de l'Estrie -Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ³Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁵Bristol-Myers Squibb Canada., St-Laurent, QC, Canada
Background/Purpose: To analyze the evolution of baseline demographic, clinical, serological and genetic characteristics of patients with incident RA over 20 years. Methods: Since July 1998,…
Abstract Number: 2827 • 2017 ACR/ARHP Annual Meeting
A Novel Statistical Method to Resolve Cellular Heterogeneity in Disease Tissues: Integrating Transcriptomic Data in Accelerating Medicines Partnership (AMP) – RA Network Phase 1 Data
Fan Zhang¹, Kamil Slowikowski², Chamith Fonseka¹, Kevin Wei³, Maria Gutierrez-Arcelus⁴, James Lederer⁵, Nir Hacohen⁶, Vivian P. Bykerk⁷, Michael Holers⁸, Peter Gregersen⁹, Mandy J. McGeachy¹⁰, Larry W. Moreland¹¹, Andrew Filer¹², Costantino Pitzalis¹³, Yvonne C. Lee¹⁴, Jennifer H. Anolik¹⁵, Michael Brenner⁴ and Soumya Raychaudhuri¹⁶, ¹Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Harvard Medical School, Boston, MA, ⁷2-005, Mt Sinai Hospital, Toronto, ON, Canada, ⁸Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁹The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ¹⁰Medicine, University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹²Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁴Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ¹⁶Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Detecting distinct cellular subsets in disease tissues is key to understanding the pathogenesis of immune diseases, for example in synovial tissues in rheumatoid arthritis…
Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting
A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression
Ilya Korsunski¹, Noémie Jourde-Chiche², Peter Gregersen³, Damien Chaussabel⁴, Laurent Chiche⁵ and Naomi I. Maria⁶, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, ³Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, ⁴Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, ⁵Internal medicine, Hopital europeen, Marseille, France, ⁶Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
Abstract Number: 2905 • 2017 ACR/ARHP Annual Meeting
TET2 Mutation Is Significantly Associated with the Development of Autoimmune Disorder in Patients with Myelodysplastic Syndrome
Yoon-Jeong Oh¹, Dong-Yeop Shin², Sang Mee Hwang³, Eun Young Lee⁴, Yeong Wook Song⁵, Dong-Soon Lee³ and Jin Kyun Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ³Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁴Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Koer, Seoul, Korea, Republic of (South), ⁶Division of Rheumatology, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis in bone marrow and peripheral cytopenia. Various genetic mutations contribute to MDS. Common mutations affect genes…
Abstract Number: 178 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population
Maria Teruel¹, Patrick Coit², Mikhail Dozmorov³, Mario Cardiel⁴, Ignacio Garcia-De La Torre⁵, Marco A Maradiaga-Ceceña Sr.⁶, José Francisco Moctezuma⁷, Maria Teresa Tusié-Luna⁸, Marta Alarcón-Riquelme^9,10 and Amr H Sawalha², ¹GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁶Hospital General de Culiacán, Culiacán, Mexico, ⁷Servicio de Reumatología, Hospital General de Mexico, Ciudad de Mexico, Mexico, ⁸Medicina Genómica y Toxicología Ambiental, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico, ⁹Uppsala University, Uppsala, Sweden, ¹⁰Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose: Our knowledge about the pivotal role DNA methylation plays in the pathogenesis of SLE has significantly increased in the last few years. However, we…

1
2
3
…
5
Next Page »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].