Abstracts tagged "genetic architecture and juvenile idiopathic arthritis (JIA)"

Abstract Number: 137 • Pediatric Rheumatology Symposium 2017
Chromatin Landscapes and Genetic Risk For Juvenile Idiopathic Arthritis
James Jarvis¹, Lisha Zhu², Lai Ping Wong³, Tao Liu⁴, Kaiyu Jiang³ and Yanmin Chen³, ¹Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Department of Biochemistry, University at Buffalo, Buffalo, NY
Background/Purpose: The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) show distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To…
Abstract Number: 70 • ACR/ARHP Annual Meeting 2016
Identifying Distal Interactions Between RUNX1 and JIA Associated Single Nucleotide Polymorphisms By Chromosome Conformation Capture
Christopher Taylor¹, Anne Hinks², Amanda McGovern¹, Helen Ray-Jones³, Kate Duffus¹, Annie Yarwood⁴, Gisela Orozco⁵, Paul Martin⁶, Wendy Thomson⁷ and Stephen Eyre⁸, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ²ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ³Centre for Musculoskeletal Research, University of MAnchester, Manchester, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁶Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ⁸The University of Manchester, Manchester, United Kingdom
Background/Purpose: 17 genetic loci have now been identified to confer susceptibility to JIA; several of these loci harbour genes involved in the IL2 pathway suggesting…
Abstract Number: 2410 • ACR/ARHP Annual Meeting 2016
Genetic Architecture of Systemic Juvenile Idiopathic Arthritis Distinguishes It from Oligoarticular and Polyarticular Forms of Juvenile Idiopathic Arthritis
Michael J. Ombrello¹, Victoria Arthur¹, Elaine F. Remmers², Anne Hinks³, Alexei Grom⁴, Dirk Föll⁵, Alberto Martini⁶, Marco Gattorno⁷, Seza Ozen⁸, Sampath Prahalad⁹, Andrew Zeft¹⁰, John F. Bohnsack¹¹, Norman Ilowite¹², Ricardo Russo¹³, Elizabeth D. Mellins¹⁴, Claudio A. Len¹⁵, Maria Odete E. Hilário¹⁶, Sheila Oliveira¹⁷, Rae S.M. Yeung¹⁸, Alan Rosenberg¹⁹, Lucy R. Wedderburn²⁰, Jordi Anton²¹, Johannes Peter Haas²², Angela Rösen-Wolff²³, Klaus Tenbrock²⁴, Susan D Thompson²⁵, Daniel L. Kastner²⁶, Patricia Woo²⁷, Wendy Thomson²⁸ and International Childhood Arthritis Genetics (INCHARGE) Consortium, ¹Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵University of Muenster, Muenster, Germany, ⁶Istituto Giannina Gaslini, Genoa, Italy, ⁷UO Pediatria 2, Istituto Giannina Gaslini, Genova, Italy, ⁸Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁹Pediatric Rheumatology, Emory University School of Medicine, Atlanta, GA, ¹⁰Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ¹¹Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT, ¹²Rheumatology, Children's Hospital Montefiore, Bronx, NY, ¹³Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁴Dept of Pediatrics CCSR, Stanford University Med Ctr, Stanford, CA, ¹⁵Pediatrics, Universidade Federal de São Paulo, São Paulo,, Brazil, ¹⁶Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati, OH, ¹⁷Pediatric Rheumatology, Universidade F Rio De Janeiro, Rio De Janeiro, Brazil, ¹⁸Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁹Pediatrics, Pediatrics, Saskatoon, SK, Canada, ²⁰Institute of Child Health, UCL, London, United Kingdom, ²¹Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ²²German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ²³Children's Hospital Dresden, Dresden, Germany, ²⁴University Aachen, Aachen, Germany, ²⁵Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ²⁶Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁷Great Ormond Street Hospital, University College London Medical School, London, United Kingdom, ²⁸Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom
Background/Purpose: JIA is a heterogeneous group of conditions that are unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA)…