Abstracts tagged "genetic architecture and juvenile arthritis"

Abstract Number: 2011 • 2018 ACR/ARHP Annual Meeting
Juvenile Arthritis-Associated Single Nucleotide Polymorphisms Identified on Whole Genome Sequencing Show Enrichment within H3K9me3-Marked Regions
Shannon O'Leary¹, Evan Tarbell², Kaiyu Jiang³, Tao Liu^1,4 and James Jarvis^5,6, ¹Genetics, Genomics, & Bioinformatics Program, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁵University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Genetics, Genomics, & Bioinformatics Program, Buffalo, NY, ⁶Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY
Background/Purpose: We have found extensive alterations in chromatin accessibility when the CD4+ T cells of children with active polyarticular juvenile idiopathic arthritis (JIA) are compared…
Abstract Number: 2016 • 2018 ACR/ARHP Annual Meeting
The Chromatin Landscape Around the Juvenile Arthritis-Associated CXCR4 Locus Suggests Regulatory Functions and Genetic Roles in Both Innate and Adaptive Immunity
Laura Easton¹, Evan Tarbell², Kaiyu Jiang³, Kyle Mentkowski⁴, Shannon O'Leary⁵, Tao Liu⁵ and James Jarvis¹, ¹Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, ²Biochemistry, University at Buffalo, Buffalo, NY, ³Pediatrics, University at Buffalo, Buffalo, NY, ⁴Graduate Program in Biological Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, ⁵Genetics, Genomics, & Bioinformatics Program, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY
Background/Purpose: CXCR4 is a recently identified susceptibility locus for juvenile idiopathic arthritis (JIA). The index single nucleotide polymorphism (SNP) used to identify this locus, rs95338,…
Abstract Number: 937 • 2017 ACR/ARHP Annual Meeting
Treatment Response in Polyarticular JIA Is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: To identify transcriptional changes in CD4+ T cells as children with polyarticular JIA transition from active disease to remission, and to identify underlying changes…

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