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Abstracts tagged "genetic adaptation and population studies"

  • Abstract Number: 2956 • ACR/ARHP Annual Meeting 2014

    Identification of Autoimmune Functional Variants Under Positive Selection in the Gullah African American Population of South Carolina

    Paula S. Ramos1, Satria Sajuthi2, Jasmin Divers2, Yiqi Huang3, Uma Nayak4, Wei-Min Chen4, Kelly J. Hunt5, Diane L. Kamen6, Gary S. Gilkeson6, Jyotika K. Fernandes7, Ida J. Spruill7, W. Timothy Garvey8, Michèle M. Sale3 and Carl D. Langefeld2, 1Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 3Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 4Public Health Sciences, University of Virginia, Charlottesville, VA, 5Public Health Sciences, Medical University of South Carolina, Charleston, SC, 6Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 7Medical University of South Carolina, Charleston, SC, 8Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…

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