Abstracts tagged "Gene Expression"

Abstract Number: 2403 • 2013 ACR/ARHP Annual Meeting
The Incidence Of Factor V Leiden A1691G, Methylene Tetrahydrofolate Reductase C677T, and Prothrombin G20210A Mutation In Patients With Rheumatoid Arthritis
Taskin Senturk¹, Zahit Bolaman², Sabri Batun³, Irfan Yavasoglu⁴ and Gurhan Kadikoylu², ¹Adnan Menderes University, Department of Rheumatology, Professor, Aydin, Turkey, ²Adnan Menderes University, Department of Hematology, Professor, Aydin, Turkey, ³Dicle University, Department of Hematology, Professor, Diyarbakır, Turkey, ⁴Adnan Menderes University, Department of Hematology, Associated Professor, Aydin, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic and inflammatory disease. Thromboembolic phenomenas are more frequent in patients with RA than healthy individuals and several…
Abstract Number: 934 • 2013 ACR/ARHP Annual Meeting
Interleukin-12B Is Up-Regulated By Decoy Receptor 3 In Specifically Rheumatoid Synovial Fibroblasts
Koji Fukuda¹, Yasushi Miura^1,2, Toshihisa Maeda¹, Shinya Hayashi³ and Masahiro Kurosaka³, ¹Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand (FasL), LIGHT,…
Abstract Number: 2190 • 2013 ACR/ARHP Annual Meeting
Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)
Hanna Kim¹, Adriana Almeida de Jesus², Yin Liu³, Yan Huang¹, Gina Montealegre⁴, Dawn Chapelle⁵, Nicole Plass¹, Wanxia Tsai⁶, Massimo Gadina⁷, Lisa G. Rider⁸, Adeline Vanderver⁹ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ³Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁴Office of the Clinical DIrector, NIAMS / NIH, Bethesda, MD, ⁵Office of the Clinical Director, NIAMS / NIH, Bethesda, MD, ⁶Translational Immunology Section, NIAMS / NIH, Bethesda, MD, ⁷Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁸Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁹Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: Increased interferon (IFN) regulated gene (IRG) expression has been reported in juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis (JDM)2. Recently, two monogenic conditions chronic…
Abstract Number: 721 • 2013 ACR/ARHP Annual Meeting
T Cell Activation Induces Increased mRNA Expression Of The Splicing Factor SF2/ASF But Simultaneous Protein Downregulation Via Proteasome Mediated Degradation
Vaishali R. Moulton¹, Andrew R. Gillooly¹ and George C. Tsokos², ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) are poor producers of the vital cytokine interleukin (IL)-2. We recently showed that SLE…
Abstract Number: 2201 • 2013 ACR/ARHP Annual Meeting
Exon and miRNA Arrays Reveal Complexity and Specificity Of The Juvenile Idiopathic Arthritis Neutrophil Transcriptome
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James N. Jarvis², ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, The University at Buffalo, Buffalo, NY, ³Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Data from the NIH Roadmap Epigenomics and ENCODE projects have revealed unexpected richness in mammalian transcriptomes. Large regions the genome that do not encode…
Abstract Number: 554 • 2013 ACR/ARHP Annual Meeting
Identification Of Stage Specific Genes Associated With Lupus Nephritis and Response To Remission induction In NZB/W Mice
Ramalingam Bethunaickan¹, Celine C. Berthier², Hong-dong Li³, Weijia Zhang⁴, Yuanfang Guan⁵, Matthias Kretzler⁶ and Anne Davidson⁷, ¹Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Department of Computational Medicine and Bioinformatics, Department of Medicine, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁷Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Our goal was to use transcriptome analysis to elucidate the molecular mechanisms involved in the immunopathogenesis of renal inflammation during the onset, remission and…
Abstract Number: 165 • 2013 ACR/ARHP Annual Meeting
New Insights Into The Metabolic Origin Of Osteoarthritis
Ignacio Rego-Pérez¹, María Eugenia Vázquez-Mosquera², Angel Soto-Hermida², Mercedes Fernández-Moreno², Juan Fernández-Tajes², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^3,4,5, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: Metabolic alterations take place in osteoarthritis (OA) and the mtDNA haplogorups influence the prevalence and severity of the disease. The aim of this work…
Abstract Number: 2204 • 2013 ACR/ARHP Annual Meeting
Early Treatment With Methotrexate Is Associated With Extensive Re-Ordering Of The Neutrophil Transcriptome In Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James N. Jarvis², ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, The University at Buffalo, Buffalo, NY, ³Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: We have previously demonstrated a role for neutrophils in polyarticulartar juvenile idiopathic arthritis (JIA) disease pathogenesis. For example, JIA neutrophils show specific abnormalities in…
Abstract Number: 534 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Gene Expression Profiling Of Psoriatic Arthritis Patient
Bidisha Dasgupta, Yauheniya Cherkas, Sarah Lamberth and Carrie Brodmerkel, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Although PsA is heterogeneous and shows signs of rheumatoid arthritis (RA) and psoriasis (PsO), genetic studies indicate that PsA is a distinct disease with…
Abstract Number: 172 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Kidney Biopsies From Chinese Patients With Lupus Nephritis Suggests a Prevalence Of Infiltrating CD8+ T Cells, Monocytes/Macrophages, and B Cells In ISN/RPS Class IV Disease
Zheng Liu¹, Chris Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen³, Gabor G. Illei⁴, Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ³Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, cincinnati, OH, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD
Transcript profiling of kidney biopsies from Chinese patients with lupus nephritis suggests a prevalence of infiltrating CD8+ T cells, monocytes/macrophages, and B cells in ISN/RPS…
Abstract Number: 2206 • 2013 ACR/ARHP Annual Meeting
Detection Of State-Specific RNA Transcripts In Juvenile Idiopathic Arthritis Neutrophils Using RNA Sequencing
Kaiyu Jiang¹, Xiaoyun Sun², Yanmin Chen¹, Yufeng Shen² and James N. Jarvis¹, ¹Pediatrics, The University at Buffalo, Buffalo, NY, ²Center for Computational Biology & Bioinformatics, Columbia University, New York, NY
Background/Purpose: Once considered non-functional, the vast regions of the human genome that do not contain protein-coding genes are now known to contain important regulatory elements. …
Abstract Number: 537 • 2013 ACR/ARHP Annual Meeting
Investigating a Novel Locus For Psoriatic Arthritis
Ashley Budu-Aggrey^1,2, John Bowes¹, Pauline Ho^1,3, James Bluett¹, Harry Hébert^1,4, Helena Marzo-Ortega⁵, Ann W. Morgan⁶, Matthew A. Brown⁷, Ross McManus⁸, Neil McHugh⁹, Oliver FitzGerald¹⁰, Ian N. Bruce^2,11,12 and Anne Barton^1,2, ¹Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵LMBRU, Chapel Allerton Hospital, and University of Leeds, Leeds, United Kingdom, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ⁸Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Ireland, Dublin, Ireland, ⁹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ¹⁰Department of Rheumatology, St.Vincent's University Hospital, Dublin, Ireland, ¹¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹²Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) is a complex genetic disorder with a prevalence of up to 1% in the general population. The association of PsA with…
Abstract Number: 175 • 2013 ACR/ARHP Annual Meeting
Dynamics Of The Inflammatory Response In Rheumatoid Arthritis Patients Following Traumatic Injury: Insights From In Vivo,In Silico, and Single Nucleotide Polymorphism Studies
Rajaie Namas¹, Rami Namas², Harpreet Sagar³, Felix Fernandez-Madrid³, Timothy Billiar² and Yoram Vodovotz⁴, ¹Rheumatology, Wayne State University/ Henry Ford Health System, Detroit, MI, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, ⁴Surgery, Immunology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Both traumatic injury/hemorrhagic shock (T/HS) and rheumatoid arthritis (RA) are inflammatory diseases that are major sources of morbidity worldwide. We hypothesize that RA modifies…
Abstract Number: 1888 • 2013 ACR/ARHP Annual Meeting
Transcriptional Regulation Of Peptidylarginine Deiminase Type IV: Implications For Rheumatoid Arthritis
Ali Abbas¹, Kevin Le¹, Virginia Pimmett¹, David A. Bell², Ewa Cairns² and Rodney P. DeKoter¹, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: High titers of anti-citrullinated protein/peptide antibodies (ACPA) have been detected in sera of rheumatoid arthritis (RA) patients, implicating citrullinating enzymes in the pathogenesis of…
Abstract Number: 492 • 2013 ACR/ARHP Annual Meeting
Distinction Between Glucocorticoid-Responders and Non-Responders In Rheumatoid Arthritis: A New Role For Endoplasmic Reticulum Aminopeptidase 2
Ruth Fritsch-Stork¹, Sandra Cardoso¹, Jasper Broen¹, Marian Groot-Koerkamp², Arno Concepcion¹, Floris Lafeber¹ and Johannes W.J. Bijlsma¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Glucocorticoids (GC) have been a cornerstone of Rheumatoid arthritis (RA)-therapy for the last decades. However, about a third of RA-patients do not respond adequately.…

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