Abstracts tagged "Gene Expression"

Abstract Number: 2865 • 2013 ACR/ARHP Annual Meeting
Gene Expression Profiles Of Fibroblast-Like Synoviocytes In Early Stage Of Oligoarticular Juvenile Idiopathic Arthritis Are Different In Extended Versus Persistent Course
AnneMarie C. Brescia¹, Megan M. Simonds², Suzanne M. McCahan², Paul T. Fawcett² and Carlos D. Rose¹, ¹Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, ²Nemours Research, Nemours/AI duPont Hospital for Children, Wilmington, DE
Background/Purpose: Our goal is the identification of informative synovial biomarkers to predict persistent vs extended course in oligoarticular JIA patients. Methods: Stored remnant synovial fluid…
Abstract Number: 1565 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing Confirms Clinical Safety Of Herpes Zoster Vaccine
Christopher J. Lessard^1,2, Indra Adrianto³, Joel M. Guthridge⁴, John A. Ice³, Graham B. Wiley³, Stuart B. Glenn³, Judith A. James^1,2, Joan T. Merrill¹, Patrick M. Gaffney¹, Courtney G. Montgomery³, Kathy L. Sivils^1,5 and Eliza Chakravarty³, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: SLE patients have increased risk of Herpes Zoster (HZ). A live-attenuated vaccine is available for healthy persons > 50 years old, but its safety…
Abstract Number: 32 • 2013 ACR/ARHP Annual Meeting
Understanding The Stimulatory Pathways Responsible For Naïve B Cell Activation In Systemic Lupus Erythematosus
Emily Blalock¹, Chris Scharer², Scott Jenks¹, Jeremy Boss² and Ignacio Sanz³, ¹Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, ³Allergy, Immunology and Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a recurrent autoimmune disease characterized by multiple B cell abnormalities, including the activation of naïve B cells. However, gaps…
Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts
Munitta Muthana¹, Holly Davies², Sachin Khetan³, Gbadebo Adeleke Adeleke⁴, Sarah Hawtree¹ and Anthony G. Wilson⁵, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, Sheffield, United Kingdom, ³Infection and immunity, Dr, Sheffield, United Kingdom, ⁴Infection and Immunity, Dr, Sheffield, United Kingdom, ⁵Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
Abstract Number: 1488 • 2013 ACR/ARHP Annual Meeting
Gene Expression Profile According To Systemic Disease Activity In Primary Sjögren’s Syndrome: Results From The Assessment Of Systemic Signs and Evolution Of Primary Sjögren’s Syndrome (ASSESS) Cohort
Nawal Rahal¹, Nicolas Cagnard², Ghada Alsaleh³, Raphaèle Seror⁴, Corinne Miceli-Richard⁵, Joelle Benessiano⁶, Philippe Dieude⁷, Jean Jacques Dubost⁸, Anne-Laure Fauchais⁹, Vincent Goeb¹⁰, Eric Hachulla¹¹, Pierre-Yves Hatron¹², C. Larroche¹³, Véronique le Guern¹⁴, Jacques Morel¹⁵, Aleth Perdriger¹⁶, Xavier Puechal¹⁷, Stephanie Rist¹⁸, Alain Saraux¹⁹, Damien Sene²⁰, Jean Sibilia²¹, Olivier Vittecoq²², Philippe Ravaud²³, Xavier Mariette²⁴ and Jacques-Eric Gottenberg²¹, ¹Strasbourg University Hospital, STRASBOURG, France, ²Institut Cochin, 75014 Paris, France, ³Univerity of Strasbourg, STRASBOURG, France, ⁴Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ⁵Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, ⁶Rheumatology, Paris Unervisity Hospital BICHAT, Paris, France, ⁷Rheumatology, Rheumatology departement & INSERM U699, Paris Diderot university, APHP, Bichat hospital, Paris, France, ⁸Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, ⁹Department of Internal Medicine A, Dupuytren Hospital, Limoges University Hospital, Limoges, France, ¹⁰Rheumatology, Amiens University Hospital, Amiens, France, ¹¹Internal Medicine, Lille CEDEX, France, ¹²Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ¹³Hospital University Bobigny, bobigny, France, ¹⁴Department of Internal Medicine, Hôpital Cochin, Paris, France, ¹⁵Montpellier University Hospital, Montpellier, France, ¹⁶Rheumatology, Hôpital Sud, Rennes, France, ¹⁷Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹⁸Rheumatology, Orleans Hospital, Orleans, France, ¹⁹Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, ²⁰Internal Medicine, Hopital Lariboisière, Paris, France, ²¹Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ²²Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, ²³Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ²⁴Paris-Sud University, Paris, France
Background/Purpose: In primary Sjögren’s syndrome (pSS), the pathogenesis of systemic complications remains unclear. Only few gene expression studies were performed and concerned a limited number…
Abstract Number: 2772 • 2013 ACR/ARHP Annual Meeting
Identification Of a Sjögren’s Syndrome-Associated Variant That Influences OAS1 Isoform Switching
He Li^1,2, John A. Ice³, Jennifer A. Kelly³, Indra Adrianto¹, Stuart B. Glenn³, Kimberly S. Hefner⁴, Evan G. Vista⁵, Donald U. Stone⁶, Raj Gopalakrishnan⁷, Glen D. Houston⁸, David M. Lewis⁹, Michael Rohrer⁷, Pamela Hughes⁷, John B. Harley^10,11, Courtney G. Montgomery³, James Chodosh¹², James A. Lessard¹³, Juan-Manuel Anaya¹⁴, Barbara M. Segal¹⁵, Nelson L. Rhodus¹⁶, Lida Radfar², R. Hal Scofield¹⁷, Christopher J. Lessard^3,18 and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁵Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, ⁶Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ⁸Collage of Denistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹¹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹²Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹³Valley Bone and Joint Clinic, Grand Forks, ND, ¹⁴Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹⁵Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a common, progressive autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth present in 0.7-1% of the European population.…
Abstract Number: 1489 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Sjögren’s Syndrome
Indra Adrianto¹, Mikhail G. Dozmorov², Graham B. Wiley¹, John A. Ice¹, He Li^1,3, Jennifer A. Kelly¹, Astrid Rasmussen¹, Donald U. Stone⁴, Juan-Manuel Anaya⁵, Barbara M. Segal⁶, Nelson L. Rhodus⁷, Lida Radfar⁸, John B. Harley^9,10, Judith A. James¹¹, Courtney G. Montgomery¹, R. Hal Scofield^12,13,14, Patrick M. Gaffney¹, Jonathan D. Wren¹, Kathy L. Sivils^1,3 and Christopher J. Lessard^1,3, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ⁶Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁷University of Minnesota, Minneapolis, MN, ⁸University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁰US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹¹Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. SS…
Abstract Number: 2559 • 2013 ACR/ARHP Annual Meeting
Effect Of NOX4 Overexpression On The Levels Of Micro RNAs Relevant To Systemic Sclerosis Fibrotic Process
Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is characterized by the excessive deposition of collagen and other connective tissue components in skin and multiple internal organs. Although transforming…
Abstract Number: 1398 • 2013 ACR/ARHP Annual Meeting
Comparison Of Atherogenicity Of Plasma From Patients With Rheumatoid Arthritis and Psoriatic Arthritis
Beenish Hafiz¹, Iryna Voloshyna², Michael J. Littlefield², Steven E. Carsons³, Elise Belilos¹, Kristina Belostocki¹, Lois A. Bonetti⁴, Gary C. Rosenblum¹ and Allison B. Reiss², ¹Rheumatology, Winthrop University Hospital, Mineola, NY, ²Medicine, Winthrop University Hospital, Mineola, NY, ³Div of Rheumatology, Winthrop University Hospital, Mineola, NY, ⁴Rheum & Immun, Winthrop University Hospital, Mineola, NY
Background/Purpose: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are immune mediated inflammatory disorders linked to increased risk of cardiovascular disease (CVD), mostly due to accelerated…
Abstract Number: 2560 • 2013 ACR/ARHP Annual Meeting
Analysis Of Global Gene Expression Of Pulmonary Endothelial Cells From Caveolin-1 Knock-Out Mice
Sonsoles Piera-Velazquez¹, Zhaodong Li¹, Sankar Addya², Peter J. Wermuth¹ and Sergio A. Jimenez¹, ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Caveolin-1 (Cav-1) deficiency has recently been shown to participate in the pathogenesis of tissue fibrosis in Systemic Sclerosis (SSc). Although the mechanisms involved have…
Abstract Number: 1284 • 2013 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and Resolution
Jordan Everett¹, Fiona E. McCann², Andrew C. Palfreeman², Anita T. Shaw³, Ellen M. Gravallese⁴ and Kimberlee S. Mix¹, ¹Biological Sciences, Loyola University New Orleans, New Orleans, LA, ²NDORMS, The Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ³Division of Rheumatology, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ⁴Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nuclear receptor 4A2 (NR4A2 / nuclear receptor related 1 / Nurr1) is a constitutively active transcription factor with diverse roles in normal physiology and…
Abstract Number: 2566 • 2013 ACR/ARHP Annual Meeting
Nilotinib Treatment Effect In The Skin As Measured By DNA Microarray In Patients With Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Tammara A. Wood², Robert F. Spiera¹ and Michael L. Whitfield², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Gene expression profiling by DNA microarray is used to identify potential biomarkers in Systemic Sclerosis (SSc). Discrete gene expression signatures have been observed to…
Abstract Number: 1175 • 2013 ACR/ARHP Annual Meeting
ABCG2 May Influence Risk Of Gout Through Extra-Renal Metabolic Pathways: Analysis Of The Effects Of The Q141K Variant On Serum Urate Responses To a Fructose Load
Nicola Dalbeth¹, Meaghan House², Gregory Gamble², Bregina Pool¹, Anne Horne², Lauren Purvis², Angela Stewart², Marilyn E. Merriman³, Murray Cadzow⁴, Amanda Phipps-Green³ and Tony R. Merriman³, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁴University of Otago, Dunedin, New Zealand
Background/Purpose: Genetic variation in ABCG2 is a major risk factor for hyperuricemia and gout. This gene encodes a high-capacity urate transporter expressed in the intestine,…
Abstract Number: 2501 • 2013 ACR/ARHP Annual Meeting
Validation Of Gene Expression Biomarkers Of Psoriatic Arthritis
Fatima Abji¹, Remy Pollock¹, Fawnda Pellett², Kun Liang³, Vinod Chandran² and Dafna D. Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a seronegative immune mediated arthritis that develops in about a third of patients with cutaneous psoriasis (PsC). The cellular pathways…
Abstract Number: 1171 • 2013 ACR/ARHP Annual Meeting
Treatment Of Psoriasis Patients With IMO-3100 Shows Improvement In Gene Expression Patterns Of Meta-Analysis Derived-3 Transcriptome and IL-17 Pathway
Mayte Suarez-Farinas¹, Jennifer Belasco¹, Tim Sullivan², Robert Arbeit² and James G. Krueger¹, ¹Krueger Laboratory, The Rockefeller University, New York, NY, ²Idera Pharmaceuticals, Inc., Cambridge, MA

Background/Purpose: IMO‑3100, an antagonist of TLRs 7 and 9, has shown significant improvement in Psoriasis Area and Severity Index (PASI) scores in a randomized, double‑blind,…

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