Abstracts tagged "Gene Expression"

Abstract Number: 554 • 2013 ACR/ARHP Annual Meeting
Identification Of Stage Specific Genes Associated With Lupus Nephritis and Response To Remission induction In NZB/W Mice
Ramalingam Bethunaickan¹, Celine C. Berthier², Hong-dong Li³, Weijia Zhang⁴, Yuanfang Guan⁵, Matthias Kretzler⁶ and Anne Davidson⁷, ¹Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, ⁴Mount Sinai School of Medicine, New York, NY, ⁵Department of Computational Medicine and Bioinformatics, Department of Medicine, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁷Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Our goal was to use transcriptome analysis to elucidate the molecular mechanisms involved in the immunopathogenesis of renal inflammation during the onset, remission and…
Abstract Number: 165 • 2013 ACR/ARHP Annual Meeting
New Insights Into The Metabolic Origin Of Osteoarthritis
Ignacio Rego-Pérez¹, María Eugenia Vázquez-Mosquera², Angel Soto-Hermida², Mercedes Fernández-Moreno², Juan Fernández-Tajes², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^3,4,5, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: Metabolic alterations take place in osteoarthritis (OA) and the mtDNA haplogorups influence the prevalence and severity of the disease. The aim of this work…
Abstract Number: 2204 • 2013 ACR/ARHP Annual Meeting
Early Treatment With Methotrexate Is Associated With Extensive Re-Ordering Of The Neutrophil Transcriptome In Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James N. Jarvis², ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, The University at Buffalo, Buffalo, NY, ³Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: We have previously demonstrated a role for neutrophils in polyarticulartar juvenile idiopathic arthritis (JIA) disease pathogenesis. For example, JIA neutrophils show specific abnormalities in…
Abstract Number: 534 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Gene Expression Profiling Of Psoriatic Arthritis Patient
Bidisha Dasgupta, Yauheniya Cherkas, Sarah Lamberth and Carrie Brodmerkel, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Although PsA is heterogeneous and shows signs of rheumatoid arthritis (RA) and psoriasis (PsO), genetic studies indicate that PsA is a distinct disease with…
Abstract Number: 172 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Kidney Biopsies From Chinese Patients With Lupus Nephritis Suggests a Prevalence Of Infiltrating CD8+ T Cells, Monocytes/Macrophages, and B Cells In ISN/RPS Class IV Disease
Zheng Liu¹, Chris Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen³, Gabor G. Illei⁴, Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ³Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, cincinnati, OH, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD
Transcript profiling of kidney biopsies from Chinese patients with lupus nephritis suggests a prevalence of infiltrating CD8+ T cells, monocytes/macrophages, and B cells in ISN/RPS…
Abstract Number: 2206 • 2013 ACR/ARHP Annual Meeting
Detection Of State-Specific RNA Transcripts In Juvenile Idiopathic Arthritis Neutrophils Using RNA Sequencing
Kaiyu Jiang¹, Xiaoyun Sun², Yanmin Chen¹, Yufeng Shen² and James N. Jarvis¹, ¹Pediatrics, The University at Buffalo, Buffalo, NY, ²Center for Computational Biology & Bioinformatics, Columbia University, New York, NY
Background/Purpose: Once considered non-functional, the vast regions of the human genome that do not contain protein-coding genes are now known to contain important regulatory elements. …
Abstract Number: 537 • 2013 ACR/ARHP Annual Meeting
Investigating a Novel Locus For Psoriatic Arthritis
Ashley Budu-Aggrey^1,2, John Bowes¹, Pauline Ho^1,3, James Bluett¹, Harry Hébert^1,4, Helena Marzo-Ortega⁵, Ann W. Morgan⁶, Matthew A. Brown⁷, Ross McManus⁸, Neil McHugh⁹, Oliver FitzGerald¹⁰, Ian N. Bruce^2,11,12 and Anne Barton^1,2, ¹Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵LMBRU, Chapel Allerton Hospital, and University of Leeds, Leeds, United Kingdom, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ⁸Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Ireland, Dublin, Ireland, ⁹Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ¹⁰Department of Rheumatology, St.Vincent's University Hospital, Dublin, Ireland, ¹¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹²Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) is a complex genetic disorder with a prevalence of up to 1% in the general population. The association of PsA with…
Abstract Number: 175 • 2013 ACR/ARHP Annual Meeting
Dynamics Of The Inflammatory Response In Rheumatoid Arthritis Patients Following Traumatic Injury: Insights From In Vivo,In Silico, and Single Nucleotide Polymorphism Studies
Rajaie Namas¹, Rami Namas², Harpreet Sagar³, Felix Fernandez-Madrid³, Timothy Billiar² and Yoram Vodovotz⁴, ¹Rheumatology, Wayne State University/ Henry Ford Health System, Detroit, MI, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, ⁴Surgery, Immunology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Both traumatic injury/hemorrhagic shock (T/HS) and rheumatoid arthritis (RA) are inflammatory diseases that are major sources of morbidity worldwide. We hypothesize that RA modifies…
Abstract Number: 1888 • 2013 ACR/ARHP Annual Meeting
Transcriptional Regulation Of Peptidylarginine Deiminase Type IV: Implications For Rheumatoid Arthritis
Ali Abbas¹, Kevin Le¹, Virginia Pimmett¹, David A. Bell², Ewa Cairns² and Rodney P. DeKoter¹, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: High titers of anti-citrullinated protein/peptide antibodies (ACPA) have been detected in sera of rheumatoid arthritis (RA) patients, implicating citrullinating enzymes in the pathogenesis of…
Abstract Number: 492 • 2013 ACR/ARHP Annual Meeting
Distinction Between Glucocorticoid-Responders and Non-Responders In Rheumatoid Arthritis: A New Role For Endoplasmic Reticulum Aminopeptidase 2
Ruth Fritsch-Stork¹, Sandra Cardoso¹, Jasper Broen¹, Marian Groot-Koerkamp², Arno Concepcion¹, Floris Lafeber¹ and Johannes W.J. Bijlsma¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Glucocorticoids (GC) have been a cornerstone of Rheumatoid arthritis (RA)-therapy for the last decades. However, about a third of RA-patients do not respond adequately.…
Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
Abstract Number: 1895 • 2013 ACR/ARHP Annual Meeting
Identification Of Aberrant Pathways In Osteoarthritis Using RNA-Seq
Kathleen M. Fisch¹, Masahiko Saito², Ryuichiro Akagi¹, Stuart Duffy¹, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan
Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease that is characterized by the destruction of articular cartilage, although the disease process affects all joint tissues. …
Abstract Number: 478 • 2013 ACR/ARHP Annual Meeting
Analysis Of The JAK1 Selectivity Of GLPG0634 and Its Main Metabolite In Different Species, Healthy Volunteers and Rheumatoid Arthritis Patients
René Galien¹, Béatrice Vayssière¹, Steve de Vos², Marielle Auberval¹, Nick Vandeghinste², Sonia Dupont¹, Philippe Clément-Lacroix¹, Philippe Delerive¹, Frédéric Vanhoutte², Reginald Brys², Annegret Van der Aa², Luc Van Rompaey² and Gerben van 't Klooster², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium
Background/Purpose: The 4 Janus kinases (JAK1, JAK2, JAK3 and TYK2) are cytoplasmic tyrosine kinases that transduce intracellular signaling for cytokines including interleukins and interferons, and…
Abstract Number: 150 • 2013 ACR/ARHP Annual Meeting
A Subset Of Osteoarthritis Individuals Has Elevated IL-6 Pathway Activation Associated With Worse Symptoms
Michael Kuziora¹, Zheng Liu², Brandon W. Higgs², Philip Brohawn², Kim Lehmann², Fernanda Pilataxi², Katie Streicher², Lydia Greenlees¹, Meina Liang³, Rozanne Lee⁴, Amy Schneider⁴, Raffaella Faggioni⁴, Yihong Yao² and Koustubh Ranade², ¹Translational Science, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Dmpk, MedImmune, LLC, Hayward, CA, ⁴DMPK, MedImmune, LLC, Hayward, CA
Background/Purpose: Elevated levels of the pro-inflammatory cytokine IL-6 have been found in the affected joint of patients with osteoarthritis (OA), although the prevalence of OA…
Abstract Number: 1883 • 2013 ACR/ARHP Annual Meeting
Fine Mapping and Expression Of a Locus Overlapping 3 Types Of Inflammatory Arthritis
Kathryn J. A Steel¹, Anne Hinks¹, Annie Yarwood², Stephen Eyre³, Edward Flynn³, Paul Martin¹, Anne Barton^3,4 and Wendy Thomson^1,5, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In a recent fine-mapping study using the Immunochip array, the RUNX1 region was strongly associated with rheumatoid arthritis (RA p=5x10-10), juvenile idiopathic arthritis (JIA…

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