Abstracts tagged "Gene Expression"

Abstract Number: 2096 • 2014 ACR/ARHP Annual Meeting
Assessment of RA Heterogeneity in Two Independent Cohorts of Patients
Joshua Joung, Yauheniya Cherkas and Sarah Lamberth, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose RA is known to be a heterogeneous disease, with heterogeneity existing in both clinical symptoms and responses to therapies. Molecular assessment of this heterogeneity…
Abstract Number: 772 • 2014 ACR/ARHP Annual Meeting
RNA-Seq and Mir-Seq Analysis of SSc Skin Across Intrinsic Gene Expression Subsets Shows Differential Expression of Non-Coding RNAs Regulating SSc Gene Expression
Zhenghui Li¹, Eleni Marmarelis², Kun Qu³, Lionel Brooks⁴, Patricia Pioli⁴, Howard Chang³, Robert Lafyatis⁵ and Michael Whitfield⁴, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Stanford University School of Medicine, Stanford, CA, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease with a heterogenous and complex phenotype. Previously, our lab has identified four gene expression subsets (fibroproliferative,…
Abstract Number: 1950 • 2014 ACR/ARHP Annual Meeting
Circulating CD19⁺CD38⁺CD43⁺ B Cell Subset in SLE Patients Have More Cell Cycle Related Genes Than Healthy Controls
Hiroshi Fujii¹, Tomoaki Machiyama¹, Kanae Akita², Yukiko Kamogawa¹, Ryu Watanabe¹, Yoko Fujita³, Yuko Shirota⁴, Shinichiro Saito⁵, Tomonori Ishii⁶ and Hideo Harigae¹, ¹Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ²Department of Heatology and Rheumatology, Tohoku University, Sendai, Japan, ³Department of Hematolgy and rheumatolgy, Tohoku University, Sendai, Japan, ⁴Department of Hematology and Rheumatolgy, Tohoku University, Sendai, Japan, ⁵Department of hematology and rheumatology, Tohoku University, Sendai, Japan, ⁶Seiryouchou Aobaku, Tohoku University, Sendai, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with deposition of autoantibodies such as anti DNA antibody. After activation of B cells…
Abstract Number: 751 • 2014 ACR/ARHP Annual Meeting
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis
Shervin Assassi¹, William Swindell², Minghua Wu¹, Filemon K. Tan¹, Dinesh Khanna³, Daniel E. Furst⁴, Donald Tashkin⁵, Richard Jahan-Tigh⁶, Maureen D Mayes¹, Johann Gudjonsson² and Jeffrey T. Chang⁶, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Dermatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴University of California at Los Angeles, Los Angeles, CA, ⁵Medicine, University of California at Los Angeles, Los Angeles, CA, ⁶University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: To examine the heterogeneity of global transcriptome patterns in systemic sclerosis (SSc) skin from a large cohort of patients and controls. Methods: Skin biopsies…
Abstract Number: 1920 • 2014 ACR/ARHP Annual Meeting
Predicting SLE Disease Activity in the Next Year Based on Measures of Four Gene Transcripts and Two Proteins
Laurence S Magder¹, Eric Zollars², Jadwiga Bienkowska³, Chris Stebbins⁴, Carrie Wager⁵, Linda Burkly⁶, Nicolas Wisniacki⁷, Ann Ranger⁸ and Michelle Petri⁹, ¹Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD, ²Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Translational Medicine, Biogen Idec Inc., Cambridge, MA, ⁴Translational Medicine, Biogen Idec, Cambridge, MA, ⁵Biostatistics, Biogen Idec, Cambridge, MA, ⁶Biogen Idec, Cambridge, MA, ⁷Formerly with Biogen Idec, Cambridge, MA, ⁸14 Cambridge Center, Biogen Idec, Cambridge, MA, ⁹Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose Multiple gene transcripts and proteins in blood or urine have been observed to correlate with disease activity in SLE. However some observed associations might…
Abstract Number: 631 • 2014 ACR/ARHP Annual Meeting
Joint and Bone Related Pathways Discriminate Psoriatic Arthritis Lesional Skin from Psoriasis vulgaris Lesional Skin
Jennifer Belasco¹, James S. Louie², Nicholas Gulati¹, Nathan Wei³, Kristine Nograles⁴, Hiroshi Mitsui¹, Mayte Suarez-Farinas¹ and James G. Krueger¹, ¹Krueger Laboratory, The Rockefeller University, New York, NY, ²Rheumatology, UCLA School of Medicine, Los Angeles, CA, ³Arthritis & Osteoporosis Center of MD, Frederick, MD, ⁴The Rockefeller University, New York, NY
Background/Purpose: It is preferable to start therapy as early as possible in psoriatic arthritis (PsA) because of the destructive nature of the arthritis. Starting treatment…
Abstract Number: 1918 • 2014 ACR/ARHP Annual Meeting
IL23 Overexpression Demonstrates Gut-Joint Inflammation Link and Increased Expression of Spondyloarthopathy Associated Genes In Vivo
Donald Souza II, Immunology & Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: It has been well established that a close relationship exists between gut inflammation and spondyloarthropathies. Polymorphisms in the receptor for IL23 are associated not…
Abstract Number: 305 • 2014 ACR/ARHP Annual Meeting
Understanding the Molecular Pathogenesis of and Response to Canakinumab Treatment in TNF Receptor-Associated Periodic Syndrome By Gene Expression Profiling of Whole Blood from Patients
R. Torene¹, M. Gattorno², H. Lachmann³, L. Obici⁴, A. Meini⁵, V. Tormey⁶, R. Caorsi⁷, L. Baeriswyl⁸, U. Affentranger⁸, S. Starck-Schwertz⁸, M. Letzkus⁸, N. Hartmann⁸, K. Abrams⁹ and N. Nirmala¹, ¹Novartis Institutes for BioMedical Research, Cambridge, MA, ²Pediatric Rheumatology, G. Gaslini Institute, Genova, Italy, ³Royal Free Hospital, London, United Kingdom, ⁴Amyloid Centre, IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Pediatric Clinic, Spedali Civili, Brescia, Italy, ⁶Galway University Hospitals, Galway, Ireland, ⁷Second Division of Paediatrics, G. Gaslini Institute, Genova, Italy, ⁸Novartis Institutes for BioMedical Research, Basel, Switzerland, ⁹Novartis Pharmaceutical Corporation, East Hanover, NJ
Background/Purpose: TNF receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disease causing unprovoked fevers, myalgia, abdominal pain, rash, headaches, and, in severe cases, AA amyloidosis. It…
Abstract Number: 1885 • 2014 ACR/ARHP Annual Meeting
Integrative Omics Profiling Reveals Dysregulated Novel Pathways Mediated By microRNAs and DNA Methylation in Osteoarthritis
Kathleen M. Fisch¹, Ryuichiro Akagi², Oscar Alvarez-Garcia¹, Takeshi Teramura¹, Yuta Muramatsu¹, Masahiko Saito³, Stuart Duffy¹, Shawn Grogan⁴, Takahisa Sasho⁵, Darryl D'Lima⁶, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan, ⁶SCORE, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease, with several identified clinical risk factors. However, the search for genetic risk factors by candidate gene and…
Abstract Number: 89 • 2014 ACR/ARHP Annual Meeting
Global miRNA Expression Profiling in Peripheral Blood and Synovial Fluid Mononuclear Cells of Patients with Enthesitis Related Arthritis
Sushma Singh, Ramnath Misra and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in India. MicroRNA dysregulation has been associated with arthritis and autoimmune diseases. In…
Abstract Number: 1756 • 2014 ACR/ARHP Annual Meeting
Molecular Diagnosis Reveals a Surprising Prevalence of Limited Gpa Among Patients with Orbital Inflammatory Diseases
James T. Rosenbaum¹, Dongseok Choi², Christine Harrington³, Patrick Stauffer⁴, David Wilson⁵, Seema Gupta⁴, Roger Dailey⁴, John Ng⁴, Eric Steele⁴, Patrick Yeatts⁶, Peter Dolman⁷, Valerie White⁷, Gerald Harris⁸, Craig Czyz⁹, Jill Foster⁹, Deepak Edward¹⁰, Hind Alkatan¹⁰, Bobby Korn¹¹, Don Kikkawa¹², Dinesh Selva¹³, Sander Dubovy¹⁴, Chris Alabiad¹⁵, David Tse¹⁵, Michael Kazim¹⁶, Payal Patel¹⁶ and Stephen R. Planck¹⁷, ¹OHSU, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³Integrated Genomics, Oregon Health & Science University, Portland, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute/Ophthalmology, Oregon Health & Science University, Portland, OR, ⁶Ophthalmology, Wake Forest University, Winston-Salem, NC, ⁷University of British Columbia, Vancouver, BC, Canada, ⁸Medical College of Wisconsin, Milwaukee, WI, ⁹Ohio State Univeristy, Columbus, OH, ¹⁰King Khaled Eye Hospital, Riyadh, Saudi Arabia, ¹¹University of California, San Diego, San Diego, CA, ¹²Ophthalmology, University of California, San Diego, San Diego, CA, ¹³Royal Adelaide Hospital, Adelaide, Australia, ¹⁴University of Miami, Miami, FL, ¹⁵Ophthalmology, University of Miami, Miami, FL, ¹⁶Columbia University, New York City, NY, ¹⁷Casey Eye Inst/Ophthalmology, Oregon Health & Science University, Portland, OR
Background/Purpose: Gene expression profiling provides diagnostic and therapeutic information in several malignancies, but its role in evaluating inflammatory disease is relatively untested. We hypothesized that…
Abstract Number: 75 • 2014 ACR/ARHP Annual Meeting
Robust Identification of Anti-TNF Non-Responders in RA from Blood
Ty Thomson, Reynald Lescarbeau, David Drubin, David Fryburg, David de Graaf, Renée Deehan, Daphna Laifenfeld and Aaron Van Hooser, Selventa, Cambridge, MA
Background/Purpose: The number of biologic therapies approved for use in treating rheumatoid arthritis (RA) has grown steadily over the past 15 years. While many patients…
Abstract Number: 1748 • 2014 ACR/ARHP Annual Meeting
CCR6⁺CD4⁺ Cells Are Counterparts of Follicular T-Cells Supporting Autoantibody Production in Rheumatoid Arthritis
Karin ME Andersson¹, Dan Hu², Ron Cialic², Nicola Cavallini³, Vijay K. Kuchroo⁴, Malin Erlandsson¹, Howard Lee Weiner² and Maria Bokarewa⁵, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Department of Neurology, Brigham and Women's Hospital, Boston, MA, ⁵Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose CCR6 has been associated with rheumatoid arthritis (RA) in genome-wide association studies. CCR6 expression characterises Th17 cells recruited to inflamed joints of RA patients.…
Abstract Number: 2978 • 2014 ACR/ARHP Annual Meeting
Characterization of the Sjögren’s Syndrome Intergenic Non-Coding RNA 1 (SSINCR1)
John A. Ice¹, He Li^2,3, Indra Adrianto², Mikhail G. Dozmorov⁴, Astrid Rasmussen⁵, Graham B. Wiley¹, Jennifer A. Kelly¹, Kimberly S. Hefner⁶, Donald U. Stone⁷, Raj Gopalakrishnan⁸, David M. Lewis⁹, Stephen Young⁹, Michael D. Rohrer⁸, Juan-Manuel Anaya¹⁰, Swamy Venuturupalli¹¹, Barbara M. Segal¹², Nelson L. Rhodus¹³, Lida Radfar¹⁴, Michael H. Weisman¹⁵, Judith A. James^16,17, Courtney G. Montgomery¹⁸, R. Hal Scofield^19,20,21, Patrick M. Gaffney¹, Linda F. Thompson²², A. Darise Farris²³, Susan Kovats¹, Jonathan D. Wren¹, Kathy L. Sivils²⁴ and Christopher J. Lessard²⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁷Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ⁹College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹¹Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹³University of Minnesota, Minneapolis, MN, ¹⁴College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁹US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ²⁰College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²²Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²³Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ²⁴Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁵825 N.E. 13th St., Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose Sjögren’s syndrome (SS) is a common autoimmune disorder characterized by immune-mediated exocrine gland destruction and systemic inflammatory responses that contribute to clinical heterogeneity. Widespread…
Abstract Number: 1723 • 2014 ACR/ARHP Annual Meeting
Identification of the Microbiome As a Potential Trigger of Systemic Sclerosis By Metagenomic RNA-Sequencing of Skin Biopsies
Michael Johnson¹, Zhenghui Li¹, Michelle Dimon², Tammara A. Wood¹, Robert Lafyatis³, Sarah Arron² and Michael Whitfield⁴, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Dermatology, University of California, San Francisco, San Francisco, CA, ³Arthritis Center, Boston University, Boston, MA, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Systemic sclerosis (SSc) is a rare and poorly understood systemic autoimmune disease that results in skin fibrosis and severe internal organ involvement. There…

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