Abstracts tagged "Gene Expression"

Abstract Number: 2869 • 2016 ACR/ARHP Annual Meeting
Critical Roles of IRAK4 Kinase Activity in Inflammation but Not B Cell Response in SLE
Chia Chi Sun¹, Gang Chen², Nuruddeen Lewis¹, Andrew T Bender¹, Changling Sia³, Ling Zhang², Catherine Jorand Lebrun⁴, Herbert Y Lin⁵, Ravi I Thadhani⁶, Harsukh Parmar¹ and Julie A DeMartino¹, ¹TIP Immunology, EMD Serono, Inc, Billerica, MA, ²EMD Serono, Inc, Billerica, MA, ³TIP Immunology, EMD Serono, Inc, Billeria, MA, ⁴Discovery Technology, EMD Serono, Inc, Billerica, MA, ⁵Division of Nephrology, Massachusetts General Hospital, Boston, MA, ⁶Divison of Nephrology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Interleukin-1 receptor (IL-1R)-associated kinase 4 (IRAK4) is a key component of the Myddosome complex, which is essential for signalling downstream of IL-1R and most…
Abstract Number: 382 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor-α -308 a/G Gene Polymorphism in Children with Juvenile Idiopathic Arthritis: Relation to Disease Activity, Damage and Disability
Tamer Gheita¹, Iman El Gazzar², Hanan Fathy³, Abeer Nour El-Din⁴, Enas Abdel Rasheed⁵, Rasha Bassyouni⁶ and Sanaa Kenawy⁷, ¹Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Egypt, Cairo, Egypt, ²Rheumatology, Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, ³Rheumatology, Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁴Pediatric Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁵Clinical Pathology Department, National Research Centre, Dokki, Egypt, Giza, Egypt, ⁶Medical Microbiology and Immunology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt, ⁷Pharmacology, Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and an important cause of disability. Its cause remains unknown, but…
Abstract Number: 1565 • 2016 ACR/ARHP Annual Meeting
Gene Modules Correlated with Disease Activity and Abatacept Treatment Identified with Weighted Gene Co-Expression Network Analysis of CD4+ T Cell Subsets of RA
Shuji Sumitomo¹, Yasuo Nagafuchi¹, Yumi Tsuchida¹, Haruka Tsuchiya¹, Mineto Ota¹, Kazuyoshi ishigaki², Shinichiro Nakachi¹, Rika Kato¹, Keiichi Sakurai¹, Norio Hanata¹, Shoko Tateishi³, Hiroko Kanda³, Akari Suzuki⁴, Yuta Kochi⁴, Keishi Fujio¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan, ³Department of Immunotherapy Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ⁴Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
Background/Purpose: Although there are several reports of transcriptome analysis of peripheral blood mononuclear cells (PBMC) in RA, analysis of detailed CD4+ subset and the effect…
Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting
Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)
Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
Abstract Number: 669 • 2016 ACR/ARHP Annual Meeting
RNA-Sequencing Reveals Sjogren’s Syndrome Anti-Ro Negative Patients Share Similar Pathways to Multiple Sclerosis Patients
Indra Adrianto¹, John Ice¹, Astrid Rasmussen², Courtney Montgomery¹, R. Hal Scofield¹, Gabriel Pardo¹, Kathy Sivils¹, Robert Axtell¹ and Christopher Lessard¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by autoantibodies to Ro and/or La proteins and lymphocytic infiltration into exocrine glands. Multiple sclerosis (MS)…
Abstract Number: 1571 • 2016 ACR/ARHP Annual Meeting
Altered Bioenergetics, Mitochondrial Function and Pro-Inflammatory Pathways in RA Synovium in Response to Tofacitinib
Carl Orr¹, Trudy McGarry², Monika Biniecka³, Jennifer McCormick⁴, Ursula Fearon⁵ and Douglas J. Veale¹, ¹Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁴Department of Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁵Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Rheumatoid arthritis (RA) is a chronic joint disease, characterised by synovial inflammation and destruction of articular cartilage/bone. The Janus-Kinase and Signal Transducer and Activator…
Abstract Number: 3117 • 2016 ACR/ARHP Annual Meeting
Development of Autoimmune Diseases and Genetic Predisposition in Children with Neonatal Lupus and Their Unaffected Siblings
Aaron Garza Romero¹, Peter M. Izmirly², Hannah C. Ainsworth³, Miranda Marion³, Carl Langefeld³, Robert Clancy⁴, Jill P. Buyon⁵ and Amit Saxena⁶, ¹Rheumatology, NYU School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Wake Forest School of Medicine, Winston-Salem, NC, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Medicine, New York University School of Medicine, New York, NY, ⁶Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies. This study was initiated to address the…
Abstract Number: 670 • 2016 ACR/ARHP Annual Meeting
Identification and Characterization of Sjogren’s Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci
Michelle L. Joachims¹, Indra Adrianto², Audrey Johnston², John Ice², Astrid Rasmussen³, Simon Bowman⁴, David M. Lewis⁵, Lida Radfar⁶, Roald Omdal⁷, Marie Wahren-Herlenius⁸, Ilias Alevizos⁹, Torsten Witte¹⁰, Roland Jonsson^11,12, Maureen Rischmueller^13,14, Patrick M. Gaffney², Judith A. James^2,15,16, Lars Rönnblom¹⁷, Elke Theander¹⁸, Nelson L. Rhodus¹⁹, Barbara M. Segal²⁰, R. Hal Scofield^2,16,21, Courtney G. Montgomery², Xavier Mariette²², Wan-Fai Ng²³, Gunnel Nordmark²⁴, Kathy L. Sivils^2,15 and Christopher J. Lessard^2,15, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ⁴Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁵Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁹Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, ¹⁰Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹¹Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ¹³Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ¹⁴Rheumatology, University of Adelaide, Adelaide, Australia, ¹⁵Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁶Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ¹⁸Department of Rheumatology, Malmö University Hospital, Lund University, Sweden, Malmö, Sweden, ¹⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁰Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ²¹US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ²²Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ²³Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune-mediated disease with hallmark features of dry eyes/mouth and autoantibodies. Genetic susceptibility to SS involves many loci, including the…
Abstract Number: 1638 • 2016 ACR/ARHP Annual Meeting
Antibody Mediated Immunity Drives Response to Methotrexate Treatment in Rheumatoid Arthritis Patients
Boel Brynedal¹, Helga Westerlind², Lasse Folkersen^3,4, Leonid Padyukov⁵, Nancy Vivar⁵, Anca I Catrina⁶, Lars Klareskog⁵ and Louise Berg⁵, ¹Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Karolinska, Sweden, ²Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, ⁵Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Methotrexate (MTX) is the first line treatment for Rheumatoid Arthritis (RA) in Sweden, but one third of patients do not experience satisfying treatment response.…
Abstract Number: 3175 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of MMF Clinical, Molecular, and Immunohistochemistry (IHC) Responses Shows SSc Patients Lose Their Inflammatory Signature and Rebound upon Treatment Cessation
Diana Toledo¹, Monique Hinchcliff², Jaclyn Taroni¹, Tammara A. Wood³, Jennifer Franks³, Sanjiv Shah⁴, Rishi Agrawal⁴, Lauren Beussink-Nelson⁴, Mary A. Carns⁵, Sofia Podlusky⁶, Patricia Pioli⁷ and Michael Whitfield³, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, IL, ⁵Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Rheumatology Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁷Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: We previously showed patients in the inflammatory subset were most likely to demonstrate improvement in modified Rodnan Skin Score (mRSS) during mycophenolate mofetil (MMF)…
Abstract Number: 800 • 2016 ACR/ARHP Annual Meeting
An Altered Cardiovascular System Development Gene Expression Signature in Skin is a Hallmark of Limited Cutaneous Systemic Sclerosis
Emma C. Derrett-Smith^1,2, Viktor Martyanov³, Cecilia B. Chighizola⁴, Pia Moinzadeh⁵, Korsa Khan⁶, Tammara A. Wood³, Pier Luigi Meroni⁷, David Abraham⁸, Voon H. Ong⁹, Michael Whitfield³ and Christopher Denton⁸, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Clinical Sciences and Community Health, University of Milan, IRCCS Istituto Auxologico Italiano, Milano, Italy, ⁵Department of Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁶Centre For Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ⁷Rheumatology Department, University of Milan, Istituto Ortopedico Gaetano Pini, Milano, Italy, ⁸Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁹Rheumatology, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Limited cutaneous SSc (lcSSc) is characterised by less extensive skin fibrosis but patients can develop major internal organ complications and vascular manifestations. Gene expression…
Abstract Number: 1665 • 2016 ACR/ARHP Annual Meeting
Validation of Germ Line Epigenetic Variants Associated with Psoriatic Disease
Remy Pollock¹, Laila Zaman¹, Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Heritable epigenetic phenomena may play a role in the parent-of-origin effect observed in psoriasis and psoriatic arthritis (PsA). A previous epigenome-wide association study (EWAS)…
Abstract Number: 3220 • 2016 ACR/ARHP Annual Meeting
Distinct Single Cell Gene Expression Signatures of Monocyte Subsets Differentiate Between TNF-Alpha Inhibitor Treatment Response Groups in Rheumatoid Arthritis
Theresa L. Wampler Muskardin¹, Wei Fan², Zhongbo Jin³, Mark A. Jensen⁴, Jessica M. Dorschner³, Yogita Ghodke-Puranik³, Kerry Wright¹, John M. Davis III⁵, Eric L. Matteson¹, Clement Michet Jr.¹, Thomas G. Mason II⁶, Scott T. Persellin⁷, Daniel Schaffer¹, Betty Dicke¹, Danielle Vsetecka³ and Timothy B. Niewold⁸, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, ³Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology - Department of Medicine, Mayo Clinic Rochester, Rochester, MN, ⁷Department of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Rheumatology and Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: In rheumatoid arthritis (RA), initiating effective treatment as soon as possible within the so-called therapeutic “window of opportunity” is the strategy, and remission is…
Abstract Number: 1611 • 2015 ACR/ARHP Annual Meeting
Gene Expression Profiling Reflects Increased Expression of Coronary Artery Disease Associated Genes in a Case-Control Matched Study of Patient with Rheumatoid Arthritis
Erica Peart¹, Kim Huffman², William E. Kraus³, Phil Beineke⁴, Jim Wingrove⁴ and Steve Rosenberg⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Durham Veterans Affairs Medical Center, Durham, NC, ³Duke Pepper Center, Durham, NC, ⁴CardioDx, Redwood City, CA
Background/Purpose: Peripheral blood gene expression profiling has been used to identify gene signatures which reflect a variety of pathologic conditions. The CorusCAD¨ test is a…
Abstract Number: 2815 • 2015 ACR/ARHP Annual Meeting
A Comparison of Th17 Gene Expression in Psoriatic Arthritis Synovial Fluid and Peripheral Blood
Fatima Abji¹, Remy Pollock², Kun Liang³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a destructive inflammatory arthritis that develops in approximately 30% of patients with cutaneous psoriasis. Th17 cells infiltrate psoriatic skin and…

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