Abstracts tagged "Gene Expression"

Abstract Number: 770 • 2017 ACR/ARHP Annual Meeting
Integrating Analysis of Skin RNA in Situ Hybridization Using Rnascope and Whole Skin Gene Expression in Systemic Sclerosis Skin to Localize Key Pathogenic Drivers of Skin Fibrosis
Corrado Campochiaro¹, Emma C. Derrett-Smith¹, Voon H. Ong², Gail Pearse³, Katherine Nevin³, Shaun Flint³, Mary Morse³, Nicolas Wisniacki⁴ and Christopher Denton⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, UCL Division of Medicine, London, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴ImmunoImflammation, GlaxoSmithKline, Stevenage, United Kingdom, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Skin gene expression profiling can distinguish SSc from normal skin and can detect different subsets of disease. Previous studies have reported a cross-sectional relationship…
Abstract Number: 1980 • 2017 ACR/ARHP Annual Meeting
Impact of Whole-Body Cryotherapy on Gene Expression of Peripheral Blood Cells in Patients with Fibromyalgia and Association with Patient-Reported Outcomes
Susanne Drynda¹, Oliver Mika² and Joern Kekow³, ¹University of Magdeburg, Clinic of Rheumatology, Vogelsang-Gommern, Germany, ²University of Magdeburg, Clinic of Rheumatology, Gommern, Germany, ³University of Magdeburg, Clinic of Rheumatology, Magdeburg, Germany
Background/Purpose: Whole-body cryotherapy (WBCT) has been demonstrated in several studies as being effective in the reduction of inflammatory symptoms and in providing pain relief. It…
Abstract Number: 2977 • 2017 ACR/ARHP Annual Meeting
Molecular Phenotypes Associated with Clinical Disease Activity in Adult Systemic Lupus Erythematosus
Rufei Lu¹, Joel M. Guthridge², Cristina Arriens³, Teresa Aberle⁴, Stan Kamp⁴, Melissa E. Munroe⁴, Tim Gross¹, Wade DeJager⁴, Susan Macwana⁴, Virginia C. Roberts⁴, Stephen Apel⁵, Hua Chen⁴, Eliza Chakravarty^6,7, Katherine Thanou⁴, Joan T. Merrill⁷ and Judith A. James⁸, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose : Remarkable clinical and pathophysiological diversity complicate diagnosis, treatment and therapeutic development in systemic lupus erythematosus (SLE). This study used molecular phenotyping to identify…
Abstract Number: 832 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis Reveals Heterogeneity of Type I IFN Gene Expression in Developing Autoreactive B Cells
Jennie Hamilton¹, PingAr Yang², Qi Wu³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Mark Walter⁷, Eleanor Fish⁸, Hui-Chen Hsu³ and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁸University Health Network & Department of Immunology, University of Toronto, Toronto General Research Institute, Toronto, ON, Canada, ⁹University of Alabama at Birmingham, Department of Medicine, Birmingham, AL
Background/Purpose: B cell development involves passage through a formative transitional B cell stage in the spleen. In SLE, self-nucleic acid reactive B cells fail to…
Abstract Number: 2191 • 2017 ACR/ARHP Annual Meeting
Widespread Regulation of Gene Expression By Glucocorticoids in Chondrocytes from OA Patients As Determined By NGS-Based Genome Wide Expression Analysis
Antti Pemmari, Erja-Leena Paukkeri, Mari Hämäläinen, Tiina Leppänen and Eeva Moilanen, The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland, Tampere, Finland
Background/Purpose: In osteoarthritis (OA), chondrocytes display marked changes in their gene expression profile. Some of these are thought to be protective [e.g. increased synthesis of…
Abstract Number: 937 • 2017 ACR/ARHP Annual Meeting
Treatment Response in Polyarticular JIA Is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: To identify transcriptional changes in CD4+ T cells as children with polyarticular JIA transition from active disease to remission, and to identify underlying changes…
Abstract Number: 2326 • 2017 ACR/ARHP Annual Meeting
Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Zihua Hu¹, Kaiyu Jiang², Mark B. Frank³, Yanmin Chen² and James Jarvis⁴, ¹Center for Computational Research, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: We have previously shown that neutrophils in children with polyarticular juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. These…
Abstract Number: 25 • 2017 ACR/ARHP Annual Meeting
A Novel Role for Galectin-3 Binding Protein in B Cell Biology and Antibody Secretion
Shinji Okitsu¹, Melinda Genest¹, Nuruddeen Lewis¹, Evgeni Tzvetkov¹, Yin Wu², Andrew Bender¹, Arnon Arazi³, Thomas Eisenhaure³, Edward Browne⁴, Alex Rolfe⁵, Jonathan Derry⁶, William Pendergraft III⁷, Nir Hacohen⁸, Julie DeMartino⁵ and Jaromir Vlach⁵, ¹TIP Immunology, EMD Serono Research and Development Institute, Billerica, MA, ²TIP Immunology, EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³Broad Institute, Cambridge, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵EMD Serono Research and Development Institute, Billerica, MA, ⁶Iris Bioconsulting, Bainbridge Island, WA, ⁷Kidney Center, University of North Carolina, Chapel Hill, NC, ⁸Harvard Medical School, Boston, MA
Background/Purpose: Antibodies are important in protection against pathogens, but also harbor the potential to cause autoimmune disease when directed against self-antigens. Systemic lupus erythematosus (SLE)…
Abstract Number: 1015 • 2017 ACR/ARHP Annual Meeting
Key Genes and Pathways between Rheumatoid Arthritis and Osteoarthritis By Integrative Genome-Wide Gene Expression Profiling Analysis
Rongqiang Zhang^1,2, Aimin Yang³, Xiaomei Ren², Jie Zhang³, Xiaoli Yang⁴, Qiling Liu², Na Sun², Puwei Yuan⁵ and Yongmin Xiong⁴, ¹School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xi'an, China, ²Shaanxi University of Chinese Medicine, Xianyang 712046, China, Xianyang, China, ³School of Public Health, Brown University, Providence, RI 02906, US, Providence, RI, ⁴School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xian, China, ⁵Shaanxi University of Chinese Medicine, Xianyang 712046, China, XianYang, China
Background/Purpose: Rheumatoid arthritis (RA) and Osteoarthritis (OA) are two most common types of joint diseases with lots of similar symptoms, and their pathological mechanisms remain…
Abstract Number: 2334 • 2017 ACR/ARHP Annual Meeting
Hypermethylation of NLRP3 Promoter Region Could be Responsible for Decreased Gene Expression, Inflammasome Malfunction and Gut Dysbiosis in Juvenile Spondyloarthritis Patients
Lovro Lamot^1,2, Kristina Gotovac Jercic³, Antonela Blazekovic³, Mirta Lamot⁴, Mandica Vidovic⁴, Fran Borovecki³ and Miroslav Harjacek^3,4, ¹Department of Pediatrics, University of Zagreb School of Medicine, Zagreb, Croatia, ²Department of Pediatrics, Division of Clinical Immunology and Rheumatology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia, ³University of Zagreb School of Medicine, Zagreb, Croatia, ⁴Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia
Background/Purpose: Juvenile spondyloarthritis (jSpA) is a complex disease with both genetic and environmental factors contributing to the etiology. Recently obtained gene signatures in jSpA patients…
Abstract Number: 165 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Risk Polymorphisms in CCR6, SNP and Estrogen-Dependent Response to Immune Mediator Gene Expression, and NF-κb Transcriptional Activity: Crosstalk between the Immune and Endocrine Systems
Ming-Fen Ho¹, Tim Bongartz², James N. Ingle³, Liewei Wang¹ and Richard M. Weinshilboum¹, ¹Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, ²Emergency Medicine, Vanderbilt University, Nashville, TN, ³Department of Medical Oncology, Mayo Clinic, Rochester, MN
Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 rs3093024 SNP is associated with increased risk of RA in a sex-specific pattern in Asian populations. Specifically,…
Abstract Number: 1019 • 2017 ACR/ARHP Annual Meeting
Molecular Profiling of RA Patients Suggests a Differential Involvement of Adaptive and Innate Cell Populations in Response to Anti-TNF Treatment
Victor Farutin¹, Thomas Prod'homme¹, Kevin McConnell¹, Nathaniel Washburn¹, Patrick Halvey¹, Jamey Guess¹, Nur Sibel Gunay¹, Jan Hillson², Carol J. Etzel³, Katherine C. Saunders³, Dimitrios A. Pappas^3,4, Anthony Manning¹, Leona Ling¹ and Ishan Capila¹, ¹Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, ²Clinical Research, Momenta Pharmaceuticals, Inc., Cambridge, MA, ³Corrona, LLC, Southborough, MA, ⁴Columbia University, New York, NY
Background/Purpose: Despite the success of anti-TNF therapies in RA, ~ 30 % of patients are non-responders. Several studies have focused on understanding the biology underlying…
Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting
Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells
Kaiyu Jiang¹, Zihua Hu², Rie Karasawa³, Yanmin Chen¹ and James Jarvis⁴, ¹Pediatrics, University at Buffalo, Buffalo, NY, ²Center for Computational Research, University at Buffalo, Buffalo, NY, ³Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
Abstract Number: 167 • 2017 ACR/ARHP Annual Meeting
Differentially Co-Expressed Gene Networks in Previously DMARD-Naïve Patients with Early RA Achieving Sustained Drug-Free Remission after Step-up Methotrexate Therapy
Xavier M Teitsma¹, Johannes WG Jacobs¹, Michal Mokry², Attila Pethö-Schramm³, Michelle EA Borm⁴, Jacob M. van Laar⁵, Johannes W.J. Bijlsma⁶ and Floris PJ Lafeber⁵, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands, ³F. Hoffmann-La Roche, Basel, Switzerland, ⁴Beneluxlaan 2a, Roche Nederland BV, Woerden, Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: According to current standards, methotrexate (MTX) is an anchor drug in the treatment of rheumatoid arthritis (RA) and should be used in the initial…
Abstract Number: 1209 • 2017 ACR/ARHP Annual Meeting
Phospholipase A2 Group 5 Is a Potential Therapeutic Target for Osteoarthritis Treatment
Ming Liu¹, Andrew Furey², Weidong Zhang³, Sergei Likhodi², Edward Randell², Proton Rahman⁴ and Guangju Zhai², ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Jilin University, Changchun, China, ⁴Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada
Background/Purpose: We recently discovered that lysophosphotidylcholines (lysoPCs) to phosphotidylcholines (PCs) ratio was associated with knee osteoarthritis (OA), suggesting that the conversion of PCs to lysoPCs…

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