Abstracts tagged "gastrointestinal complications"

Abstract Number: 838 • 2016 ACR/ARHP Annual Meeting
Esophageal Dysmotility and Interstitial Lung Disease in Patients with Scleroderma: A Retrospective Study
Shweta Kishore¹, Santhanam Lakshminarayanan¹, Chia-Ling Kuo² and Ranadeep Mandhadi¹, ¹Division of Rheumatology, University of Connecticut, Farmington, CT, ²Department of Community Medicine and Health Care, University of Connecticut, Farmington, CT
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease with pulmonary involvement seen in 75% of patients and esophageal involvement in 90% of the patients.…
Abstract Number: 839 • 2016 ACR/ARHP Annual Meeting
Immunosuppression Does Not Prevent Severe Gastrointestinal Disease in Systemic Sclerosis
Nicolas Richard¹, Marie Hudson², Mianbo Wang³, Murray Baron⁴, Genevieve Gyger¹ and Canadian Scleroderma Research Group, ¹McGill University, Jewish General Hospital, Montreal, QC, Canada, ²Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ³Lady Davis Institute for Medical Research, Montreal, QC, Canada, ⁴Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Severe gastrointestinal (GI) disease is associated with considerable morbidity and high mortality in systemic sclerosis (SSc). There are no known preventative treatments. We wished…
Abstract Number: 974 • 2016 ACR/ARHP Annual Meeting
Diffuse Scleroderma, Male Sex, and Myopathy Are Associated with Severe Gastrointestinal Dysmotility in Scleroderma
Zsuzsanna McMahan¹, Livia Casciola-Rosen² and Fredrick M. Wigley³, ¹Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Despite the fact that up to 90% of scleroderma (SSc) patients are affected by gastrointestinal (GI) dysmotility, features associated with severe GI disease are…
Abstract Number: 1853 • 2016 ACR/ARHP Annual Meeting
Klf5+/-;Fli1+/- Mice Recapitulate Protracted Wound Healing and Cardiac and Intestinal Involvement Associated with Systemic Sclerosis
Kouki Nakamura¹, Yoshihide Asano², Takuya Miyagawa³, Megumi Hirabayashi³, Takashi Yamashita³, Ryosuke Saigusa¹, Shunsuke Miura², Tetsuo Toyama^3,4, Takehiro Takahashi¹, Yohei Ichimura¹, Takashi Taniguchi¹, Ayumi Yoshizaki³, Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis. Although the most recognizable manifestation is skin disease, SSc can…
Abstract Number: 1884 • 2016 ACR/ARHP Annual Meeting
Esophageal Dilation and Interstitial Lung Disease Incidence and Progression in Systemic Sclerosis
Kimberly Showalter¹, Aileen Hoffmann², Carrie Richardson^3,4, Julia (Jungwha) Lee⁵, David Aaby⁶, Rishi Agrawal⁷, Jane Dematte⁸, Rowland W. Chang⁹ and Monique Hinchcliff¹⁰, ¹Internal Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, ²Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, ⁴Department of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Preventive Medicine/Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Pulmonology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁹Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁰Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in systemic sclerosis (SSc). Esophageal dysfunction and aspiration may play a role in SSc-ILD.…
Abstract Number: 2015 • 2016 ACR/ARHP Annual Meeting
The Systemic Sclerosis Disease State Is Associated with Specific Alterations in Gastrointestinal Microbiota in Two Independent Cohorts
Elizabeth R. Volkmann¹, Anna-Maria Hoffmann-Vold², Yu-Ling Chang³, Jonathan Jacobs⁴, Philip J. Clements⁴, Martin Kummen², Johannes R. Hov², Kirsten Tillisch¹, Venu Lagishetty¹, Oyvind Midtvedt⁵, Øyvind Molberg⁵ and Jonathan Braun³, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Oslo University Hospital, Oslo, Norway, ³Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Rheumatology, Oslo University Hospital, Oslo, Norway
Background/Purpose: A single center study demonstrated that systemic sclerosis (SSc) patients have a distinct colonic microbial consortium (based on lavage specimens) compared with healthy controls…
Abstract Number: 2359 • 2016 ACR/ARHP Annual Meeting
Dose-Related Risks of Cardiovascular, Gastrointestinal, and Renal Adverse Events Associated with Meloxicam Among Patients with Osteoarthritis: An Observational Study Using US Claims Data
Elaine Hoffman¹, Deirdre M. Mladsi¹, Byron Cryer², William Hopkins³, D. Craig Brater⁴, Rohan Parikh¹, Ravi Goyal¹, Jordi Castellsague⁵, Dana Stafkey-Mailey⁶ and Clarence Young⁷, ¹Health Economics, RTI Health Solutions, Research Triangle Park, NC, ²University of Texas Southwestern Medical School, Dallas, TX, ³Fletcher Allen Health Care, University of Vermont College of Medicine, Burlington, VT, ⁴Indiana University School of Medicine, Bloomington, IN, ⁵Epidemiology, RTI Health Solutions, Barcelona, Spain, ⁶Xcenda, AmerisourceBergen, Palm Harbor, FL, ⁷Iroko Pharmaceuticals, LLC, Philadelphia, PA
Background/Purpose: Safety studies have shown that risks associated with non-steroidal anti-inflammatory drugs (NSAIDs) are related to dose; however, there is little evidence regarding this dose-toxicity…
Abstract Number: 2895 • 2016 ACR/ARHP Annual Meeting
Adaptation of UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Questionnaire into Turkish
Murat Yasar Tas¹, Gozde Dervis Hakim², Pembe Keskinoglu³, Gokce Kenar⁴, Handan Yarkan⁵, Berrin Zengin⁴, Gerçek Can⁵, Fatos Onen⁴, Nurullah Akkoc⁴, Mesut Akarsu⁶ and Merih Birlik⁴, ¹Internal Medicine, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Gastroenterology, Ataturk State Hospital, Sinop, Turkey, ³Department of Biostatistics and Medical Informatics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ⁴Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ⁵Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, ⁶Gastroenterology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
Background/Purpose: Nearly 90% of patients with scleroderma (SSc) have gastrointestinal tract(GIT) involvement in variable severities and is a challenging process for clinicians.The University of California…
Abstract Number: 829 • 2015 ACR/ARHP Annual Meeting
Fecal Incontinence and Association with Bowel Dysfunction in Systemic Sclerosis: A Canadian Multicenter Study
Nicolas Richard^1,2, Marie Hudson², Genevieve Gyger², Murray Baron³, Evelyn Sutton⁴, Nader A. Khalidi⁵, Janet E. Pope⁶, Nathalie Carrier¹, Maggie J. Larche⁵, Alexandra Albert⁷, Paul R. Fortin⁷, Carter Thorne⁸, Ariel Masetto⁹ and Canadian Scleroderma Research Group, ¹Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²McGill University, Jewish General Hospital, Montreal, QC, Canada, ³Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁴Rheumatology, Dalhousie University, Nova Scotia Rehabilitation Centre, Halifax, NS, Canada, ⁵McMaster University, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁶Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada, ⁷Université Laval, CHU de Québec, Québec, QC, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: Gastrointestinal (GI) tract involvement is a common and serious complication of systemic sclerosis (SSc). However, the prevalence of fecal incontinence (FI) and its relationship…
Abstract Number: 831 • 2015 ACR/ARHP Annual Meeting
Mycophenolate Decreases the Frequency of Endoscopic Therapy for Gastric Antral Vascular Ectasia in Patients with Systemic Sclerosis
Tiffany Lin¹, James Bena², Shannon Morrison² and Soumya Chatterjee³, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Gastric antral vascular ectasia (GAVE) is an increasingly recognized cause of upper gastrointestinal bleeding in patients with systemic sclerosis (SSc). These patients may require…
Abstract Number: 940 • 2015 ACR/ARHP Annual Meeting
NOD2-Associated Autoinflammatory Disease: Therapy and Outcomes
Qingping Yao¹ and Bo Shen², ¹Cleveland Clinic, Cleveland, OH, ²Gastroenterology, Cleveland Clinic, Cleveland, OH
Background/Purpose: NOD2-associated autoinflammatory disease, now redesignated as Yao Syndrome(YS) is a newly described and increasingly recognized entity. It is characterized by periodic fever, dermatitis, polyarthritis, sicca-like…
Abstract Number: 2978 • 2015 ACR/ARHP Annual Meeting
Longitudinal Assessment of Gastrointestinal Symptoms in the Prospective Registry of Early Systemic Sclerosis Cohort
Tracy M. Frech¹, Maureen Murtaugh², Jessica K. Gordon³, Robyn T. Domsic⁴, Ami A. Shah⁵, Faye N. Hant⁶, Shervin Assassi⁷, Monique E. Hinchcliff⁸, Elana J. Bernstein⁹, Virginia D. Steen¹⁰, Victoria K. Shanmugam^11,12 and Dinesh Khanna¹³, ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake, UT, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁸Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Columbia University, New Yory, NY, ¹⁰Rheumatology, Georgetown University Medical Center, Washington, DC, ¹¹Director, Division of Rheumatology, The George Washington University, Washington, DC, ¹²Division of Rheumatology, The George Washington University, Washington, DC, ¹³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) is a multicenter incident cohort study of patients with early diffuse cutaneous systemic sclerosis (dcSSc; <…
Abstract Number: 2979 • 2015 ACR/ARHP Annual Meeting
Laser Speckled Imaging and Videomicroscopy Assessment of Sublingual Perfusion in Systemic Sclerosis and Healthy Controls
Mark Sievert¹, Daniel R. Machin², Anthony J. Donato², Maureen Murtaugh³, John D. Pauling⁴, Robyn T. Domsic⁵, Lee S. Shapiro⁶ and Tracy M. Frech⁷, ¹University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³University of Utah, Salt Lake, UT, ⁴Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Steffens Scleroderma Center, Albany, NY, ⁷Div of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: Our group has previously described the sublingual frenulum abnormalities in systemic sclerosis (SSc, scleroderma). The goal of this project was to assess microvascular abnormalities…
Abstract Number: 3129 • 2015 ACR/ARHP Annual Meeting
Integrative Analysis of the Colonic Microbiota in Systemic Sclerosis
Elizabeth R. Volkmann¹, Yu-Ling Chang², Nashla Barroso³, Daniel E. Furst³, Philip J. Clements¹, Alan Gorn⁴, Bennett Roth³, Jeffrey Conklin³, Terri Getzug³, Maomeng Tong², Jonathan Jacobs³ and Jonathan Braun², ¹Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA
Background/Purpose: Gastrointestinal tract (GIT) dysfunction is a leading cause of morbidity in patients with systemic sclerosis (SSc). However, the etiology of SSc-related lower GIT dysfunction…
Abstract Number: 3136 • 2015 ACR/ARHP Annual Meeting
Impact of Prokinetic Agents on Systemic Sclerosis-Associated Gastrointestinal Disease: A Systematic Review
Annaliese Tisseverasinghe¹, Ahmad Kadhim², Ambica Parmar², Louis Liu² and Sindhu R. Johnson¹, ¹Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ²Division of Gastroenterology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: More than 90% of patients with Systemic Sclerosis (SSc) have gastroinstestinal (GI) involvement, commonly dysmotility causing complications such as gastroesophageal reflux and constipation. Treatment…

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