ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Functional Genomics"

  • Abstract Number: 1928 • 2019 ACR/ARP Annual Meeting

    Identification of Immunological Processes Associated with the Response to Abatacept in Rheumatoid Arthritis Using Longitudinal Blood RNA-seq Analysis

    Antonio Julià1, Maria Lopez Lasanta 2, Antonio Gómez 3, Irene Bonafonte 4, Raimon Sanmartí 5, Carlos Marras 6, José Manuel Pina 7, Susana Romero-Yuste 8, Raul Veiga 9, Pilar Navarro 9, Carmen Moragues Pastor 10, Silvia Martínez 11, Francisco J. De Toro 12, Amalia Sanchez 13, Dacia Cerdà 14, Alejandro Prada 15, Alba Erra 16, Jordi Monfort 17, A. Urruticoechea-Arana 18, Núria Palau 19, Raquel Lastra 20, Raúl Tortosa 3, Andrea Pluma 21 and Sara Marsal 22, 1Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Catalonia, Spain, 2Hospital Universitari Vall Hebrón, Barcelona, Barcelona, Catalonia, Spain, 3Hospital Vall d'Hebron, Barcelona, Barcelona, Spain, 4Vall Hebron Hospital Research Institute, Barcelona, Spain, 5Hospital Clínic, Barcelona, Barcelona, Spain, 6Hospital Universitario Virgen de la Arrixaca, Murcia, Murcia, Spain, 7Hospital de Barbastro, Huesca, Barbastro, Huesca, Spain, 8Complejo Hospitalario Universitario Pontevedra, Pontevedra, Galicia, Spain, 9Hospital Universitario Fuenlabrada, Fuenlabrada, Spain, 10Platò Hospital, Barcelona, Spain, Barcelona, Spain, 11Hospital Universitari Mútua Terrassa, Terrassa, Spain, 12University Hospital A Coruña, A Coruña, Spain, 13Hospital Universitario Lucus Augusti, Lugo, Lugo, Spain, 14Hospital Moisès Broggi, Sant Joan Despí, Sant Joan Despí, Spain, 15Hospital Universitario Torrejón de Ardoz, Torrejón de Ardoz, Spain, 16Hospital Sant Rafael, Barcelona, Barcelona, Spain, 17Hospital del Mar, Barcelona, Spain, 18HU Can Misses, Ibiza, Spain, 19Hospital Vall Hebrón Barcelona, Barcelona, Spain, 20Hospital Vall Hebron, Barcelona, Barcelona, Spain, 21Hospital Universitari Vall d'Hebron, Barcelona, Spain, 22Vall d’Hebron Hospital, Barcelona, Catalonia, Spain

    Background/Purpose: Abatacept (CTLA4-Ig) is an approved biological therapy for the treatment of rheumatoid arthritis (RA). Similar to other biological agents, most patients (50-60%) respond significantly…
  • Abstract Number: 1014 • 2017 ACR/ARHP Annual Meeting

    The Rheumatic Disease Data Refinery: A Case Study in Integrative Genomics Reveals Complex IFN Signatures in Therapeutic Studies in SLE

    Jaclyn N Taroni and Casey S. Greene, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Over the past 15 years, more than 10,000 whole tissue biopsies from patients with rheumatic diseases have been deposited into publicly available gene expression…
  • Abstract Number: 2429 • 2017 ACR/ARHP Annual Meeting

    Towards Precision Medicine in Rheumatoid Arthritis (RA): Trans-Ethnic Analysis and Prioritization of SNPs in the AFF3 Locus

    Vincent A. Laufer1, Maria I. Danila2, Richard J. Reynolds3, Leah C. Kottyan4, Kenneth Kaufman5, John B. Harley6, Carl D Langefeld7, Donna Arnett8 and S. Louis Bridges Jr.9, 1Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 6Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Wake Forest University, Winston Salem, NC, 8University of Kentucky College of Public Health, Lexington, KY, 9Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL

    Background/Purpose: Genetic variants in AFF3 have been associated with RA, including in our GWAS and ImmunoChip analyses of African-Americans (610 RA; 1543 controls). Likewise, an…
  • Abstract Number: 2636 • 2017 ACR/ARHP Annual Meeting

    EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion through Junctional Adhesion Molecule-a in Lupus Patients

    Pei-Suen Tsou1, Patrick Coit1, Nathan Kilian2 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: EZH2 is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and modulates DNA methylation patterns. We have previously suggested that EZH2…
  • Abstract Number: 2931 • 2017 ACR/ARHP Annual Meeting

    Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems

    Bhaven K. Mehta1, Jennifer Franks2, Guoshuai Cai2, Diana Toledo3, Tammara A. Wood2, Kimberly A. Archambault1, Noelle Kosarek1, Kathleen Kolstad4, Marianna Stark5, Antonia Valenzuela6, David Fiorentino7, Nielsen Fernandez-Becker8, Laren Becker8, Linda Nguyen8, John Clarke9, Francesco Boin10, Paul Wolters11, Lorinda Chung12 and Michael L. Whitfield1, 1Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 3Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 4Rheumatology, Stanford University Medical Center, Stanford, CA, 5Stanford University, Stanford, CA, 6Stanford University School of Medicine, Stanford, CA, 7Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, 8Gastroenterology & Hepatology, Stanford University School of Medicine, Palo Alto, CA, 9Medicine/Gastroenterology, Stanford University, Stanford, CA, 10Rheumatology, University California, San Francisco, San Francisco, CA, 11Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, 12Rheumatology, Stanford University Medical Center, Palo Alto, CA

    Background/Purpose: While skin fibrosis is a hallmark of systemic sclerosis (SSc), internal organ involvement is the primary cause of morbidity and mortality, often related to…
  • Abstract Number: 70 • 2016 ACR/ARHP Annual Meeting

    Identifying Distal Interactions Between RUNX1 and JIA Associated Single Nucleotide Polymorphisms By Chromosome Conformation Capture

    Christopher Taylor1, Anne Hinks2, Amanda McGovern1, Helen Ray-Jones3, Kate Duffus1, Annie Yarwood4, Gisela Orozco5, Paul Martin6, Wendy Thomson7 and Stephen Eyre8, 1Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 2ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 3Centre for Musculoskeletal Research, University of MAnchester, Manchester, United Kingdom, 4Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 5Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 6Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, 7Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, 8The University of Manchester, Manchester, United Kingdom

    Background/Purpose: 17 genetic loci have now been identified to confer susceptibility to JIA; several of these loci harbour genes involved in the IL2 pathway suggesting…
  • Abstract Number: 76 • 2016 ACR/ARHP Annual Meeting

    Chromatin Interactions Reveal Novel Gene Targets for Drug Repositioning in Rheumatic Diseases

    Paul Martin1, Amanda McGovern1, Kate Duffus1, Annie Yarwood1, Anne Barton2,3, Jane Worthington1,2, Stephen Eyre1 and Gisela Orozco3, 1Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The treatment of rheumatic diseases can be both expensive and ineffective with up to 1/3 of patient’s failing to respond to current treatments. There…
  • Abstract Number: 2843 • 2014 ACR/ARHP Annual Meeting

    SLE Patients Carrying a Disease-Associated PTPN22 R620W Variant Show Reduced Interferon-Inducing Capacity

    Yaya Wang1, David Ewart2, Ami Yamamoto2, Emily C. Baechler1, Parastoo Fazeli3 and Erik J. Peterson2, 1Medicine, University of Minnesota, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Division of Rheumatic and Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose Type 1 interferons (IFN) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Increased expression of IFN-regulated genes, termed the IFN-signature, correlates with…
  • Abstract Number: 2454 • 2014 ACR/ARHP Annual Meeting

    Genetic Influences on Rheumatoid Arthritis in African-Americans

    Vincent A. Laufer1,2, Richard J. Reynolds3, Maria I. Danila4, Gordon Wu5, Amit Patki5, Devin Absher6, Carl D. Langefeld7, R. Curtis Hendrickson8, Elliot J. Lefkowitz9, Ted R. Mikuls10, Peter K. Gregersen11, Elizabeth E. Brown8, Robert P. Kimberly8, John B. Harley12, Donna K. Arnett8, Hemant K. Tiwari5 and S. Louis Bridges Jr.8,13, 1Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham Medical Scientist Training Program, Birmingham, AL, 3Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 6Hudson Alpha Institute for Biotechnology, Huntsville, AL, 7Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 8University of Alabama at Birmingham, Birmingham, AL, 9Microbiology, University of Alabama at Birmingham, Birmingham, AL, 10Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 11Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, 12Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 13Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Rheumatoid arthritis (RA) affects 0.5-1% of the population worldwide. The genetics of RA has been analyzed in large European and Asian studies, but much…
  • Abstract Number: 869 • 2014 ACR/ARHP Annual Meeting

    UBE2L3 genotype Influences Plasma Cell Proliferation in Systemic Lupus Erythematosus By Regulation of NF-κB By the Linear Ubiquitination Assembly Complex

    Myles J. Lewis1, Simon Vyse1, Adrian M. Shields2, Sebastian Boeltz2, Patrick Gordon3, Timothy D. Spector4, Paul J. Lehner5, Henning Walczak6 and Timothy J. Vyse2, 1Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, 2Medical & Molecular Genetics, King's College London, London, United Kingdom, 3Department of Rheumatology, King's College London, London, United Kingdom, 4Department of Twin Research, King's College London, London, United Kingdom, 5Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, 6Centre for Cell Death, Cancer and Inflammation, University College London, London, United Kingdom

    Background/Purpose: Genome-wide association studies have identified a strong association between a single risk haplotype of the UBE2L3gene and Systemic Lupus Erythematosus (SLE), as well as…
  • Abstract Number: 2494 • 2013 ACR/ARHP Annual Meeting

    Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopaptidase 1 Variants In Antigen Presentaing Cells Affect HLA-B27 Free Heavy Chain Expression and Binding To NK-Cell Receptors

    Nigil Haroon1,2,3 and Zhenbo Zhang3, 1Rheumatology, University Health Network, Toronto, ON, Canada, 2Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, 3Toronto Western Research Institute, Toronto, ON, Canada

    Background/Purpose: ERAP1 and HLA-B27 are strongly associated with ankylosing spondylitis (AS). Using well-controlled tissue culture systems, we studied the effects of AS-associated ERAP1 variants on…
  • Abstract Number: 538 • 2013 ACR/ARHP Annual Meeting

    Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopeptidase 1 Variants Alter The Unfolded Protein Response

    Nigil Haroon1,2,3 and Zhenbo Zhang3, 1Rheumatology, University Health Network, Toronto, ON, Canada, 2Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, 3Toronto Western Research Institute, Toronto, ON, Canada

    Background/Purpose: Endoplasmic reticulum aminopeptidase 1 (ERAP1) has recently been identified to be strongly associated with HLA-B27 positive AS. We have shown that ERAP1 variants cause…
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology