Abstracts tagged "Fra-2"

Abstract Number: 1045 • 2019 ACR/ARP Annual Meeting
Myocardial Involvement in SSc: Key Role of Lin-gp38+ Stromal Cells in the Onset of Fibrosis and Defects of the Conduction System
Mara Stellato¹, Michal Rudnik ², Florian Renoux ³, Przemyslaw Blyszczuk ⁴, Elena Osto ⁵, Matthias Dewenter ⁶, Petra Seebeck ⁷, Elena Pachera ², Oliver Distler ⁸ and Gabriela Kania ⁴, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, ⁴Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Institute of Clinical Chemistry, University Hospital Zurich, Switzerland, Zurich, Zurich, Switzerland, ⁶Department of Molecular Cardiology and Epigenetics, University Hospital, Heidelberg, Germany, Heidelberg, Germany, ⁷Zurich integrative Rodent Physiology, University of Zurich, Switzerland, Zurich, Switzerland, ⁸Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Cardiac fibrosis is a known complication of SSc, associated with increased mortality. During fibrogenesis, fibroblasts differentiate into myofibroblasts and secrete excessive extracellular matrix proteins.…

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