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Abstracts tagged "foxo"

  • Abstract Number: 890 • ACR/ARP Annual Meeting 2019

    Adenosine A2A Receptor Signaling Activates FoxO1 and FoxO3 and Promotes Cartilage Autophagy

    Benjamin Friedman1, Carmen Corciulo 2, Cristina Castro-Rivera 2 and Bruce Cronstein 2, 1Department of Medicine, Division of Rheumatology NYUSoM, NYC, 2NYU Langone, New York

    Background/Purpose: Osteoarthritis (OA) is a debilitating and costly condition caused by loss of articular cartilage secondary to chondrocyte dysfunction. Autophagy is a homeostatic pathway that…

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