Abstracts tagged "fibrosis and systemic sclerosis"

Abstract Number: 774 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Synergistically Increases TGF-β-Induced Hif1α Expression Under Normoxic Conditions during Endothelial-to-Mesenchymal Transition in Murine Endothelial Cells. a Novel Mechanism for the Fibrogenic Effects of Endothelin
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Tissue hypoxia is a consequence of vascular damage and Hif-1α accumulation is a major mechanism of hypoxia response pathways. HIF-1α induces the transcriptional upregulation…
Abstract Number: 769 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of an Investigational Drug: Bis-Oxetanyl Sulfoxide
Logan Mlakar¹, Takahisa Takihara², Melissa Sprachman³, Peter Wipf⁴ and Carol Feghali-Bostwick¹, ¹Medical University of South Carolina, Charleston, SC, ²Tokai University School of Medicine, Kanagawa, Japan, ³Massachusetts General Hospital, Boston, MA, ⁴Chemisry, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The hallmark of pulmonary fibrosis is thickening and scarring of the tissue caused by increased deposition of extracellular matrix (ECM) proteins like collagen…

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