Abstracts tagged "fibrosis and systemic sclerosis"

Abstract Number: 113 • 2018 ACR/ARHP Annual Meeting
Epigenetic Changes in Dermal Fibroblasts By Inhibition of DOT1L Affect Cell Proliferation and Cell Cycle, but Have No Direct Effects on Collagen Deposition in in Vitro and In Vivo models of Fibrosis
Nathalie Berghen^1,2, Jonathan Cremer³, Ellen de Langhe^1,2 and Rik Lories^1,2, ¹Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium, ²Rheumatology, UZ Leuven, Leuven, Belgium, ³Translational Research in GastroIntestinal Disorders, KU Leuven, Leuven, Belgium
Background/Purpose: Fibrosis is a key feature of systemic sclerosis, a devastating disease that is not well understood. The role of epigenetic factors in the pathophysiology…
Abstract Number: 115 • 2018 ACR/ARHP Annual Meeting
CTLA4-Ig/CD86 Interaction on Cultered Human Fibrocytes and Fibroblasts from Systemic Sclerosis Patients
Maurizio Cutolo¹, Paola Montagna², Stefano Soldano¹, Amelia Chiara Trombetta³, Barbara Ruaro⁴, Paola Contini⁵, Sabrina Paolino⁶, Carmen Pizzorni⁴, Elisa Alessandri⁴, Massimo Patanè¹, Alberto Sulli⁴, Stefano Scabini⁷, Emanuela Stratta⁷ and Renata Brizzolara¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genova, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ⁵Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy, ⁶Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ⁷Oncologic Surgery, Department of Surgery, IRCCS Polyclinic San Martino, Genova, Italy, Genoa, Italy
Background/Purpose: CTLA4-Ig interacts with the cell surface costimulatory molecule CD86 and can downregulate the target cell activation [1]. Circulating fibrocytes (CFs) express markers of both…
Abstract Number: 119 • 2018 ACR/ARHP Annual Meeting
Targeting Dysregulated CD38/NAD+ Homeostasis Mitigates Multiple Organ Fibrosis
Bo Shi¹, Wenxia Wang², Swati Bhattacharyya¹, Benjamin Korman³, Roberta Goncalves Marangoni¹, David Camp⁴, Paul Cheresh⁵, Guilherme de Oliveira⁶, Eduardo Chini⁷ and John Varga¹, ¹Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Division of Pulmonary and Critical Care, Northwestern University, Chicago, IL, ⁵Northwestern University, CHICAGO, IL, ⁶Mayo Clinic of Medicine, Rochester, MN, ⁷Kogod Center on Aging, Mayo Clinic, Rochester, MN
Background/Purpose: Persistent myofibroblast activation underlies unresolving multi-organ fibrosis in systemic sclerosis (SSc). We had shown that fibrosis is associated with reduced expression of NAD-dependent sirtuins…
Abstract Number: 128 • 2018 ACR/ARHP Annual Meeting
Inhibition of Prolyl-tRNA Synthetase As a Novel Therapeutic Target for Systemic Sclerosis
Caroline H. Lee¹, Seong-Jin Yoon¹, Minjae Cho¹, Joon Seok Park², Yena Kim³, Ji Hyeon Ju⁴, Da-Jeong Bae⁵, Choon-Sik Park⁵, Jong Hyun Kim⁶, Sunghoon Kim⁶ and Bongyong Lee¹, ¹Daewoong Pharmaceuticals, Seoul, Korea, Republic of (South), ²Daewoong pharmaceutical, Seoul, Korea, Republic of (South), ³Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital, Seoul, Korea, Republic of (South), ⁶Medicinal Bioconvergence Research Center, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Prolyl-tRNA synthetase (PRS), a member of aminoacyl tRNA synthetases (ARS), is an enzyme that conjugates amino acid proline to its tRNA to generate prolyl-tRNA…
Abstract Number: 1023 • 2018 ACR/ARHP Annual Meeting
Plasmacytoid Dendritic Cells That Infiltrate the Lungs Produce Profibrotic Cytokines and Chemokines in Bleomycin-Induced Model of Systemic Sclerosis
Isela Valera¹ and Ram R. Singh², ¹Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, ²UCLA, Los Angeles, CA
Background/Purpose: In bleomycin-induced model of systemic fibrosis and patients with systemic sclerosis, plasmacytoid DC (pDC) are unaffected or reduced systemically (spleen/peripheral blood) but they increase…
Abstract Number: 1899 • 2018 ACR/ARHP Annual Meeting
Down-Regulation of RNA Processing Protein CFIm25 Amplifies Skin Fibrosis By up-Regulating Pro-Fibrotic Transcripts/Proteins in Systemic Sclerosis
Tingting Mills¹, Junsuk Ko¹, Jingjing Huang¹, Minghua Wu², Ningyuan Chen¹, Leng Han¹, Yu Xiang¹, Maureen D. Mayes³, Eric Wagner⁴, Michael Blackburn¹ and Shervin Assassi², ¹Department of Biochemistry & Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁴Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Galveston, TX
Background/Purpose: Persistent myofibroblast activation and associated excessive extracellular matrix protein deposition are hallmarks of systemic sclerosis (SSc). However, the mechanisms that account for this excessive fibrotic response remain…
Abstract Number: 1901 • 2018 ACR/ARHP Annual Meeting
Reduced SPAG17 Expression Links Dysfunctional Cilia, Morphogen Signaling Activation and Multiple Organ Fibrosis: Novel Target for Systemic Sclerosis
Paulene Sapao¹, Bo Shi², Elisha D.O. Roberson³, John Atkinson⁴, Jerome Strauss¹, Maria Teves¹ and John Varga², ¹Virginia Commonwealth University, Richmond, VA, ²Northwestern University, Chicago, IL, ³Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, ⁴Medicine/Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: Persistent myofibroblast activation driving progressive fibrosis is the defining hallmark of systemic sclerosis (SSc). Uniquely, fibrosis in SSc affects the skin, heart, lungs and…
Abstract Number: 2688 • 2017 ACR/ARHP Annual Meeting
Collagen Metabolite Biomarker Levels Are Associated with the Amount of Fibrosis in Internal Organs in Systemic Sclerosis Patients
Anne Sofie Siebuhr¹, Satoshi Kubo², Pernille Juhl³, K Nakano⁴, S Nakayamada⁵, Morten Karsdal⁶, Anne-C. Bay-Jensen⁷ and Yoshiya Tanaka⁸, ¹the first department of internal medicine, University of occupational and environmental health, Fukuoka, Japan, ²The first department of internal medicine, University of Occupational en environmental Health, Fukuoka, Japan, ³Nordic Bioscience, Herlev, Denmark, ⁴the first department of internal medicin, University of occupational and environmental health, fukuoka, Japan, ⁵The first department of internal medicine, University of Occupational and environmental Health, fukuoka, Japan, ⁶Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁷Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, ⁸The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Biomarkers that can monitor the fibrotic burden will aid in trial enrichment and personalized health care in SSc. SSc is associated with internal organ…
Abstract Number: 724 • 2017 ACR/ARHP Annual Meeting
Antibodies Against the Chemokine Receptors CXCR3 and CXCR4 Predict Progressive Lung Fibrosis in Systemic Sclerosis (SSc)
Gabriela Riemekasten¹, Elise Siegert² and Harald Heidecke³, ¹Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany, ²Rheumatology and Clinical Immunology, University Hospital Charité, Berlin, Germany, ³CellTrend GmbH Luckenwalde, Luckenwalde, Germany
Background/Purpose: Chemokine receptors CXCR3 and CXCR4 are involved in immune cell migration and in the pathogenesis of inflammatory fibrosis, a key feature of systemic sclerosis…
Abstract Number: 760 • 2017 ACR/ARHP Annual Meeting
Antisense Long Noncoding RNA HAND2-AS1 and OTUD6B-AS1 Have Important Roles in the Pathogenesis of Systemic Sclerosis
Miki Takata¹, Elena Pachera¹, Anastasiia Kozlova¹, Astrid Jüngel¹, Tobias Messemaker², Jeska de Vries-Bouwstra², Tom W.J. Huizinga³, Fina Kurreeman² and Oliver Distler⁴, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, Leiden, Netherlands, ³Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ⁴Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) represent a class of transcripts longer than 200 nucleotides that are not translated into proteins. In recent years, antisense (AS)…
Abstract Number: 1927 • 2017 ACR/ARHP Annual Meeting
Anti-Fibrotic Mechanisms of Endostatin-Derived Peptide Are the Result of Reduction in Pro-Fibrotic Mediators and Promotion of Extracellular Matrix Degradation
Tomoya Watanabe¹, Tetsuya Nishimoto², Takahisa Takihara³, Logan Mlakar⁴, Yunyun Su⁵ and Carol A. Feghali-Bostwick⁶, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ³Division of Pulmonary Medicine, Tokai University School of Medicine, Isehara, Japan, ⁴Medical University of South Carolina, Charleston, SC, ⁵Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, ⁶Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Fibrotic disorders such as systemic sclerosis (SSc) result in end-stage organ failure and loss of function, consequently causing high morbidity and mortality. We recently…
Abstract Number: 805 • 2016 ACR/ARHP Annual Meeting
HLA Class II Functional Motifs Associated with Severe Systemic Sclerosis (SSc) and Sclerotic Graft Versus Host Disease (sclGVHD): The Shared Epitopes of Fibrosis
Jelena Blagojevic^1,2, David Venzon³, Lorenzo Beretta⁴, Edward W Cowen⁵, Laurin M Curtis⁶, Marco Matucci-Cerinic⁷, Steven Z Pavletic⁸ and Francesco Del Galdo⁹, ¹Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, Bethesda, MD, ⁴Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Dermatology Branch, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, ⁶Experimental Transplantation and Immunology Branch, National Cancer institute (NCI), National Institutes of Health (NIH), Bethesda,, Bethesda, MD, ⁷Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁸Experimental Transplantation and Immunology Branch, National Cancer institute (NCI), National Institutes of Health (NIH), Bethesda, Bethesda, MD, ⁹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Single Nucleotide polymorphisms within the HLA region have been strongly associated with the occurrence of SSc and sclGVHD. However, specific studies on the amino…
Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting
Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis
Anastasiia Kozlova¹, Elena Pachera¹, Florian Renoux², Michal Rudnik¹, Britta Maurer¹, Astrid Jüngel³, Joerg H.W Distler⁴, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, ⁴Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
Abstract Number: 816 • 2016 ACR/ARHP Annual Meeting
Clinical Response to Treatment with Belimumab and Mycophenolate Mofetil Is Associated with Decrease in B Cell, TGF-β and PDGF Signaling in Systemic Sclerosis
Viktor Martyanov¹, Jessica K. Gordon², Tammara A. Wood¹, Robert F. Spiera² and Michael L. Whitfield¹, ¹Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: While B cell signaling is thought to be important in the pathogenesis of systemic sclerosis (SSc), the experience with B cell targeting therapies in…
Abstract Number: 817 • 2016 ACR/ARHP Annual Meeting
RNA and Protein Cargo of Exosomes Isolated from Serum of Systemic Sclerosis Patients Induce a Profibrotic Phenotype in Cultured Normal Human Dermal Fibroblasts: A Potential Mechanism for the Initiation and Progression of a Profibrotic Phenotype in SSc
Peter J. Wermuth, Kellan R. Carney, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Exosomes are lipid bilayer-bound microvesicles that contain various macromolecules including numerous microRNA (miRNA) and proteins. Exosomes mediate intercellular communication by fusing and releasing their…

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