Abstracts tagged "fibrosis and inflammation"

Abstract Number: 3131 • ACR/ARHP Annual Meeting 2015
Interferon Regulatory Factor 7 (IRF7): The Possible Link Between Inflammation and Fibrosis in SSc Pathogenesis
Minghua Wu¹, Gloria Salazar¹, Xiaodong Zhou², Xinjian Guo², John D. Reveille³, Sandeep K. Agarwal⁴, Michael R. Blackburn⁵, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Internal Medicine, University of Texas Medical School at Houston, Houston, TX, ³Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Internal Med, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX
Background/Purpose: A recent global gene expression profile study in a large early SSc patient samples revealed a type I interferon (IFN) signature. Type I IFN…