ACR Meeting Abstracts

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Abstracts tagged "Fibrosing syndromes"

  • Abstract Number: 0026 • ACR Convergence 2024

    Conserved Pro-Fibrotic Fibroblast Signatures in Osteoarthritis Synovium and Systemic Sclerosis Skin

    Michael Newton1, Aanya Mohan2, Tareq Hanna3, Dana Orange4, John Varga2 and Tristan Maerz2, 1University of Michigan, South Lyon, MI, 2University of Michigan, Ann Arbor, MI, 3Wayne State University, Detroit, MI, 4The Rockefeller University, New York, NY

    Background/Purpose: Synovial fibrosis is a hallmark of osteoarthritis (OA) and a clinical correlate to joint pain. Fibrosis of skin, lungs and other organs is the…
  • Abstract Number: 0785 • ACR Convergence 2024

    Exploring the Link Between Atgl-Dependent Lipolysis and Dermal Fibrosis in Systemic Sclerosis

    Elizabeth Caves1, Agrani Dixit1, Anna Jussila2, Vivian Lei3, Hailey Edelman4, Muhammad Hamdan5, Ian Odell5, Monique Hinchcliff6, Radhika Atit7 and Valerie Horsley1, 1Yale School of Medicine, New Haven, CT, 2Stanford Medicine, Stanford, CA, 3University of North Carolina School of Medicine, Chapel Hill, 4Vanderbilt School of Engineering, New Haven, 5Yale School of Medicine, New Haven, 6Yale School of Medicine, Westport, CT, 7Case Western Reserve University College of Arts and Sciences, Cleveland

    Background/Purpose: Resident lipid-filled dermal adipocytes are depleted in both systemic sclerosis (SSc) and scleroderma mouse models, but mechanisms are poorly understood. We undertook studies in mouse…
  • Abstract Number: 0956 • ACR Convergence 2024

    Secreted Frizzled-Related Protein 2 (sFRP2) Regulates Wnt Signaling to Affect Mesenchymal Transition of Lung Epithelial Cells Participates in Interstitial Lung Disease

    Yinlan Wu1, Yanhong Li2 and Yi Liu3, 1West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2West China School of Medicine and West China Hospital, Sichuan University, Cheng Du, Sichuan, China, 3West China Hospital, Sichuan University, Chengdu, China (People's Republic)

    Background/Purpose: Investigation of Transcriptional Changes in Interstitial Lung Disease (ILD) and Exploration of Functional Effects of Differential Genes and Expressed Proteins in the Development of…
  • Abstract Number: 1663 • ACR Convergence 2024

    Notch—mediated Fibrogenic Activation Is a Spatial Determinant of RA Treatment Response

    Kartik Bhamidipati1, Ce Gao1, Ksenia Anufrieva2, Shideh Kazerounian3, Roopa Madhu4, Miles Tran1, Vikram Khedgikar1, Sonia Presti1, Anna Helena Jonsson5, ilya Korsunsky1 and Kevin Wei6, 1Brigham and Women's Hospital, Boston, MA, 2BWH, Cambridge, MA, 3Brigham & Women's Hospital, Boston, MA, 4Brigham and Women's Hospital, Brookline, MA, 5University of Colorado School of Medicine, Aurora, CO, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: In RA, poor treatment response has been linked to a fibroid synovial tissue phenotype, characterized by lack of immune cell infiltration and an expansion…
  • Abstract Number: 2027 • ACR Convergence 2024

    Clinical Features and Treatment of Retroperitoneal Fibrosis in a Referral Hospital and Literature Review

    Adrián Martín-Gutiérrez1, Javier Loricera2, Fernando Lopez-Gutierrez3 and Ricardo Blanco-Alonso4, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 4Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Retroperitoneal fibrosis (RPF) is usually idiopathic (iRPF), but may be secondary to drugs, neoplasms, infections, or may be part of an IgG4-related disease. Our…
  • Abstract Number: 2661 • ACR Convergence 2024

    Changes in Krebs Von Den Lungen 6 Levels (∆KL6) Predict Fibrosing Progression of Interstitial Lung Disease in Patients with an Underlying Connective Tissue Disease (CTD-ILD)

    Fredeswinda Romero-Bueno1, María Carmen Vegas-Sánchez2, lydia Abasolo Alcazar3, Mª Jesus Rodriguez Nieto2, Cristina Vadillo-Font4, M Asuncion Nieto5, Laura Cebrián6, Belén López-Muñiz6, Jesus Loarce Martos7, Juan Rigual8, hildegarda Godoy Tundidor9, Rosalía Laporta10, Irene Llorente-Cubas11, Gema Bonilla12, Luis Gomez Carrera13, Rosario García-Vicuña14, Ana Jaureguizar7, Jose Luis Morell Hita7, Claudia Valenzuela15 and Olga Sánchez-Pernaute16, and the NEREA Study group for Autoimmune ILD, 1Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain, 2Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, 3IdISSC. HCSC, Madrid, Spain, 4Hospital Clinico S Carlos, Madrid, Spain, 5Hospital Clínico San Carlos, Madrid, Madrid, Spain, 6Hospital Universitario Infanta Leonor, Madrid, Spain, 7Hospital Universitario Ramón y Cajal - IRYCIS, Madrid, Spain, 8Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 9Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, 10Hospital Universitario Puerta de Hierro, Madrid, Spain, 11Hospital Universitario de La Princesa, Madrid, Spain, 12H. Universitario La Paz, Madrid, Spain, 13Hospital Universitario La Paz, Madrid, Spain, 14Hospital Universitario de la Princesa, Madrid, Madrid, Spain, 15Hospital Universitario La Princesa, Madrid, Spain, 16Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain

    Background/Purpose: Krebs von den Lungen-6 (KL6) is a mucin-1 glycoprotein produced by type 2 alveolar epithelial cells , which increase at peripheral blood show a…
  • Abstract Number: 2686 • ACR Convergence 2024

    Dose Escalation Safety Study of Brentuximab Vedotin for Diffuse Cutaneous Systemic Sclerosis:Clinical Results and Mechanistic Analysis of Skin and Peripheral Blood Mononuclear Cells

    David Fox1, Laura Cooney2, Lia Stelzig3, Robert Lafyatis4, Johann Gudjonsson5, Lam Tsoi6, Maureen Mayes7, Ankoor Shah8, Suzanne Kafaja9, William Barry3, Ellen Goldmuntz10, Dawn Smilek11 and Dinesh Khanna6, 1University of Michigan, Dexter, MI, 2University of Michigan and Immune Tolerance Network, Ann Arbor, MI, 3Rho, Durham, NC, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 5Department of Dermatology, University of Michigan, Ann Arbor, MI, 6University of Michigan, Ann Arbor, MI, 7UTHealth Houston Division of Rheumatology, Houston, TX, 8Duke University, Durham, NC, 9Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 10Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, 11Immune Tolerance Network, UCSF, San Francisco, CA

    Background/Purpose: Brentuximab vedotin (ADCETRIS®) is a drug antibody conjugate targeting CD30 approved for treatment of Hodgkin’s lymphoma (HL) and other hematologic malignancies. Association of CD30…
  • Abstract Number: 0713 • ACR Convergence 2023

    IgG4-Related Disease as a Potencial Etiology of Idiopathic Constrictive Pericarditis

    Edwin Ulises Cortez-Domínguez1, Gabriela Hernandez-Molina1, Norma Ofelia Uribe-Uribe2, María J Lizardo-Thiebaud2 and Eduardo Martin-Nares1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Constrictive pericarditis (CP) is a type of diastolic heart failure characterized by impaired cardiac filling due to the presence of an inelastic pericardium. Histologically,…
  • Abstract Number: 0935 • ACR Convergence 2023

    Sodium Pyruvate Improves Mitochondrial Fitness in SSc Fibroblasts to Prevent Fibroblast-to-myofibroblast Transition and Fibrotic Remodeling

    Xiang Zhou1, Thuong Trinh-Minh1, Alexandru-Emil Matei1, Honglin Zhu2, Hermina Györfi1, Cuong Tran Manh1, Xuezhi Hong1 and Joerg Distler1, 1Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. 5 Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China

    Background/Purpose: Systematic sclerosis (SSc) is an autoimmune disease characteristic by fibroblast transition and overproduction of extracellular matrix, yet with limited treatment. Recent studies provided evidence…
  • Abstract Number: 0945 • ACR Convergence 2023

    The Nuclear Receptor TR4 Orchestrates Cytoskeletal Organization in a Gα12/ROCK-dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

    Yun Zhang1, Lichong Shen2, yi-nan Li1, Hermina Györfi1 and Joerg Distler1, 1Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for…
  • Abstract Number: 0957 • ACR Convergence 2023

    Rationale for Targeting Insulin-like Growth Factor Signalling in Systemic Sclerosis

    Voon Ong1, Shiwen Xu2, Li Xue2, Brajesh Kumar3 and Christopher Denton2, 1UCL Medical School Royal Free Campus, London, United Kingdom, 2University College London, London, United Kingdom, 3Horizon Therapeutics, South San Francisco, CA

    Background/Purpose: Previous studies have shown that insulin like growth factor (IGF) pathways may promote extracellular matrix deposition and be upregulated in systemic sclerosis (SSc). Teprotumumab,…
  • Abstract Number: 0962 • ACR Convergence 2023

    Topological Proteomic Differences in Fibrotic and Unaffected Skin in Scleroderma

    Irene Choi1, Courtney Yu2, Francesco Boin1, Elizabeth Volkmann3, Stephanie Stanford2 and Nunzio Bottini4, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of California San Diego, San Diego, CA, 3University of California Los Angeles, Los Angeles, CA, 4University of California, San Francisco, CA

    Background/Purpose: Scleroderma (SSc) is a chronic autoimmune and rheumatic disease characterized by varying levels of tissue fibrosis in the skin and other internal organs. It…
  • Abstract Number: 1517 • ACR Convergence 2023

    Comparing Deep Neural Network to Modified Rodnan Skin Score in a Trial for Belumosudil in Systemic Sclerosis Patients

    Baran Gunes1, Lucy Duran Camacho1, Shawn Cowper2, Gauri Panse2, Elizabeth Bundschuh3, Alyssa Williams4, Nicolas Page5, Mary Karns6, Kathleen Aren6, Niki Pradhan7, Elana Bernstein8, Sarah Fantus9, Elizabeth Volkmann10, Heather Bukiri10, Chase Correia11, Francis Wilson1, Seamus Mawe12, J. Matthew Mahoney13, Monique Hinchcliff14 and Rui Wang15, 1Yale University School of Medicine, New Haven, CT, 2Yale School of Medicine - Dermatopathology, New Haven, CT, 3Yale University School of Medicine, New York, NY, 4Yale University School of Medicine, Winchester, MA, 5Yale University School of Medicine, Salem, CT, 6Northwestern University Division of Rheumatology, Chicago, IL, 7Columbia University Irving Medical Center, New York, NY, 8Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 9Kansas City Physician Partners- Center for Rheumatic Disease, Kansas City, MO, 10University of California Los Angeles, Los Angeles, CA, 11Riverside Medical Group, Hampton, VA, 12The Jackson Laboratory, Bar Harbor, ME, 13Jackson Laboratory, Bar Harbor, ME, 14Yale School of Medicine, Westport, CT, 15Sanofi, Cambridge, MA

    Background/Purpose: We previously published a proof-of-principle study demonstrating the potential utility of computer vision (Deep Neural Network/DNN) methods applied to stained skin biopsy sections from…
  • Abstract Number: 2359 • ACR Convergence 2023

    Reversal of the Activation State of Pro-fibrotic CD206 Positive Macrophages by Therapeutic Peptide AUR300 in Systemic Sclerosis

    Sandra Lopez1, Bahja Ahmed Abdi1, Linda Lei1, Anas Al-Oweidi1, Claire Macfadyen1, Lydia Nagib1, Sarah Ive1, Anshul Kumar1, Teresa Collins1, Jennifer Cross2, Christopher Denton1, David Abraham1, Clayton Yates3, Charles Garvin4, Henry Lopez4, George Martin5 and Richard Stratton1, 1University College London, London, United Kingdom, 2Aurinia Pharmaceuticals Inc., Rockford, MD, 3Tuskegee University, Tuskegee, AL, 4Riptide Bioscience Inc., Valejo, CA, 5Riptide Bioscience Inc., Bethesda, MD

    Background/Purpose: A spectrum of macrophage activation is seen in human pathologic conditions; M2-like CD206 positive macrophages are pro-fibrotic and proresolution, while M1-like macrophages are proinflammatory,…
  • Abstract Number: 1056 • ACR Convergence 2022

    Clinical Characterization of a Cohort of Patient with Sclerotic-type Chronic Graft-versus-host Disease with Fascial/joint Involvement

    Cristina Hidalgo1, Concepción Roman2, Olga Compan3, Sonia Pastor Navarro4, Marta Ibañez5, Belen Miguel6, Maria Dolores Sanchez7, Lucía Pantoja8, Carlos Montilla5 and Lucía López-Corral2, 1Hospital Universitario Salamanca, Salamanca, Spain, 2Universitary Hospital, Salamanca, Spain, 3Complejo asistencial Universitario de Palencia, Carbajosa De La Sagrada, Spain, 4Hospital Universitario de Salamanca, Salamanca, Spain, 5Complejo asistencial Universitario de Salamanca, Salamanca, Spain, 6University Hospital, Salamanca, Spain, 7Universitary Hospital, Valladolid, Spain, 8Complejo Asistencial Hospital General, Segovia, Spain

    Background/Purpose: Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation (allo-HCT). Its chronic form usually involves a multisystemic syndrome that reflects…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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