Abstract Number: 960 • 2012 ACR/ARHP Annual Meeting
Cyclobenzaprine (CBP) and Its Major Metabolite Norcyclobenzaprine (nCBP) Are Potent Antagonists of Human Serotonin Receptor 2a (5HT2a), Histamine Receptor H-1 and á-Adrenergic Receptors: Mechanistic and Safety Implications for Treating Fibromyalgia Syndrome by Improving Sleep Quality
Background/Purpose: Bedtime cyclobenzaprine (CBP) improves fibromyalgia symptoms (pain, fatigue, tenderness, and mood) and improves sleep quality (decreases Cyclic Alternating Pattern Type A2 + A3) (1).…Abstract Number: 1879 • 2012 ACR/ARHP Annual Meeting
Work Related Injuries Causing or Aggravating Fibromyalgia in the Medicolegal Arena: A Jurisprudential Analysis
Background/Purpose: Up to 40% of persons report onset of fibromyalgia (FM) following a “triggering event”. Injuries, which may occur in the workplace, may be implicated…Abstract Number: 963 • 2012 ACR/ARHP Annual Meeting
Efficacy of Long-Term Milnacipran Treatment in Patients Meeting Different Thresholds of Clinically Relevant Pain Relief: Subgroup Analysis of a Double-Blind, Placebo-Controlled Discontinuation Study
Background/Purpose: Patients with fibromyalgia (FM) who received up to 3.25 years of milnacipran (MLN) in a flexible-dose (≤200 mg/d) open-label (OL) study were eligible to…Abstract Number: 1881 • 2012 ACR/ARHP Annual Meeting
Increased Psychosocial Stress Is a Major Component of Fibromyalgia Triggers
Background/Purpose: Fibromyalgia is a common, chronic pain disorder. Initial development of symptoms occurs under conditions unique to each patient. Psychological and physical triggers are recognized,…Abstract Number: 967 • 2012 ACR/ARHP Annual Meeting
Haplotypes of GTP Cyclophydrolase Gene Polymorphisms Are Protective in the Susceptibility of Fibromyalgia Syndrome
Background/Purpose: Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, which is an essential co-factor in nitric oxide (NO) production.…Abstract Number: 1882 • 2012 ACR/ARHP Annual Meeting
Predictors of a Favorable Outcome in Patients with Fibromyalgia: Results From the 1-Year Follow-up
Background/Purpose: To determine the outcomes in Korean patients with fibromyalgia (FM) and identify the prognostic factors associated with improvement at 1-year follow-up. Methods: Forty-eight patients…Abstract Number: 952 • 2012 ACR/ARHP Annual Meeting
Cognitive Behavioral Therapy and Milnacipran in Combination Appears to Be More Efficacious Than Either Therapy Alone
Background/Purpose: The two treatment options that have received the significant attention in fibromyalgia (FM) management are cognitive behavioral therapy (CBT) and medications. Given the fact…Abstract Number: 1860 • 2012 ACR/ARHP Annual Meeting
Fibromyalgia and the Disease and Statistical Manual Classification As a Somatic Symptom Disorder
Background/Purpose: Fibromyalgia was first defined by rheumatologists, and is often thought of as a disorder of widespread pain and decreased pain threshold. In the wider…Abstract Number: 953 • 2012 ACR/ARHP Annual Meeting
Comparative Symptom Severity of Patients Satisfying Chronic Widespread Pain and Fibromyalgia Criteria
Background/Purpose: Chronic widespread pain (CWP) is often used as a surrogate for fibromyalgia in epidemiological research, particularly in Europe and in whiplash-related injuries. This CWP…Abstract Number: 1865 • 2012 ACR/ARHP Annual Meeting
Emotional Pain and Catastrophizing Influence Quality of Life in Fibromyalgia
Background/Purpose: Fibromyalgia (FM) is a composite of symptoms with the pivot symptom of pain, traditionally measured as intensity with little attention to other qualities. Emotional…Abstract Number: 866 • 2012 ACR/ARHP Annual Meeting
Pain Is Associated with Telomere Shortening in Women with Fibromyalgia
Background/Purpose: Telomere length is considered a marker of cellular aging and has been linked to an increased risk for morbidity and mortality. Psychosocial factors associated…Abstract Number: 1866 • 2012 ACR/ARHP Annual Meeting
Association of Opioid Use with Symptom Severity and Quality of Life in Patients with Fibromyalgia
Background/Purpose: Chronic widespread pain is a cardinal symptom in patients with fibromyalgia. Current pharmacotherapies for fibromyalgia targets central neurochemical abnormalities and pain processing pathways. Analgesics…Abstract Number: 867 • 2012 ACR/ARHP Annual Meeting
Events That Trigger the Onset of the Fibromyalgia Syndrome (FMS)
Background/Purpose: Triggering events – those that are followed by the onset or rapid increase in FMS symptoms – have a significant impact in some cases. …Abstract Number: 2646 • 2012 ACR/ARHP Annual Meeting
Cost-Effectiveness of Tai Chi Mind-Body Exercise for the Treatment of Fibromyalgia
Background/Purpose: Although fibromyalgia is associated with substantial annual direct medical and indirect productivity costs, the cost-effectiveness of treatments for fibromyalgia remains understudied. A randomized…Abstract Number: 1867 • 2012 ACR/ARHP Annual Meeting
Assessment of ART Therapy Program for Women with Fibromyalgia: Randomized, Controlled, Blinded Study
Background/Purpose: Fibromyalgia (FM) is a chronic non-inflammatory syndrome characterized by diffuse pain throughout the body, sleep disorder, stiffness, fatigue, depression and other psychological problems. Patients…