Abstracts tagged "Fibroblasts, Other"

Abstract Number: 1805 • ACR Convergence 2025
Human meniscus histopathological and transcriptomic changes at early and advanced stages of knee osteoarthritis
Takuya Sakamoto¹, Merissa Olmer¹, chelsea Kenvisay¹, Rachel Miller², Anne-Marie Malfait³, Darryl D'Lima⁴, William Bugbee⁵, Hannah Swahn⁶ and Martin Lotz⁷, ¹Scripps Research Institute, La Jolla, CA, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴Scripps Clinic, San Diego, CA, ⁵Scripps Clinic, La Jolla, CA, ⁶Scripps Research Institute, Carlsbad, CA, ⁷Scripps Research, La Jolla, CA
Background/Purpose: The knee menisci are essential in joint biomechanics while meniscus damage is a driver of knee osteoarthritis (OA) and an important source of knee…
Abstract Number: 1752 • ACR Convergence 2025
Prg4+ Ligament Cells Are Involved in Ligament Ossification in Ankylosing Spondylitis
Kunhai Tang¹, Lilu Zu¹, Chenyuan Wu¹, Jiucun Wang¹ and Jing Liu², ¹Fudan University, shanghai, China (People's Republic), ²Fudan University, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Ankylosing spondylitis(AS) is a chronic inflammatory disease with clinical symptoms characterized by inflammatory low back pain and spinal ankylosis due to ligament ossification. Enthesitis…
Abstract Number: 1684 • ACR Convergence 2025
Integration of Multiple Spatial Transcriptomics Reveals Novel Insights into Sjogren Disease Salivary Gland Fibroblast by Peripheral Serostatus
Zhou Fang¹, Ahmet Coskun¹ and Sara McCoy², ¹Georgia Tech, Atlanta, ²University of Wisconsin–Madison, Madison, WI
Background/Purpose: Anti-SSA antibody positive (SSA+ [Ro52 or Ro60]) and negative (SSA-) Sjögren disease (SjD) have differing clinical phenotypes and prognostic features; however, the pathogenesis driving…
Abstract Number: 1682 • ACR Convergence 2025
Sjögren’s Disease Salivary Gland Fibroblast Subsets are Proinflammatory and Aberrantly Promote Pain
Sara McCoy¹, Rachael Bogle², michele larsen³, Li Chen⁴, thomas pranzatelli⁵, Paola Perez⁶, john chiorini⁷, Alan Baer⁸, A. Darise Farris⁹, Christopher Lessard⁹, Astrid Rasmussen⁹, Caroline Shiboski¹⁰, Stephen Shiboski¹⁰, Alexander Mikesell³, Zachary Campbell³, Alex Tsoi², Johann Gudjonsson¹¹ and Blake M. Warner¹², ¹University of Wisconsin–Madison, Madison, WI, ²University of Michigan, Holland, OH, ³University of Wisconsin, Madison, ⁴University of Michigan, Ann Arbor, ⁵NIH, Bethesda, ⁶NIDCR, Bethesda, MD, ⁷NIH, bethesda, MD, ⁸Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰University of California San Francisco, San Francisco, CA, ¹¹University of Michigan, Ann Arbor, MI, ¹²National Institutes of Health, Bethesda, MD
Background/Purpose: Fibroblasts (fb) are increasingly recognized as dynamic signaling hubs in rheumatic disease, yet their contribution to Sjögren Disease (SjD) remains poorly defined. We dissect…
Abstract Number: 1560 • ACR Convergence 2025
Longitudinal assessment of circulating fibroblast activation protein in systemic sclerosis-associated interstitial lung disease
Bo Broens¹, Conny van der Laken¹, Iris Simons¹, Tamara Dekker¹, Jan Willem Duitman¹ and Alexandre Voskuijl², ¹Amsterdam UMC, Amsterdam, Netherlands, ²Amsterdam University Medical Center, Amsterdam, Netherlands
Background/Purpose: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is difficult to manage due to the heterogeneous disease course. There is a high need for biomarkers to…
Abstract Number: 2539 • ACR Convergence 2024
Telocytes Integrated into Mast Cells and Joint-Draining Lymphatic Vessels Potentially Regulate Lymphatic Clearance
Yue Peng¹, H. Mark Kenney², Karen Bentley¹, Lianping Xing³, Benjamin Korman⁴, Christopher Ritchlin⁵ and Edward Schwarz¹, ¹University of Rochester School of Medicine and Dentistry, Rochester, NY, ²University of Rochester School of Medicine and Dentistry, Henrietta, NY, ³University of Rochester School of Medicine and Dentistry, Webster, NY, ⁴University of Rochester, Rochester, NY, ⁵Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY
Background/Purpose: Rheumatoid arthritis (RA) patients and TNF-transgenic mice have lymphatic dysfunction (1). Recently, we showed mast cells involvement, as genetic ablation and drug inhibition decreased…
Abstract Number: 2550 • ACR Convergence 2024
Infiltrating and Resident Macrophages in Lupus Nephritis: Scar Associated Macrophage Phagocytic Dysfunction and Fibroblast Activation
Chirag Raparia¹, Paul Hoover², Arnon Arazi³, Nir Hacohen⁴ and Anne Davidson⁵, ¹Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, ²Brigham and Women's Hospital, SWAMPSCOTT, MA, ³Feinstein Institutes for Medical Research, Melrose, MA, ⁴Broad Institute of MIT and Harvard, Boston, MA, ⁵Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Lupus nephritis (LN) is driven by a heterogeneous population of renal macrophages. We have previously reported that the renal macrophage subpopulations are similar in…
Abstract Number: 0054 • ACR Convergence 2024
Supernatants from Macrophages Stimulated with Citrullinated and MAA-Modified Fibrinogen Contain PDGF-BB and TGF-b and Upregulate Fibrotic Markers in Human Lung Fibroblasts
Nozima Aripova¹, Michael Duryee¹, Bryant England¹, Carlos Hunter¹, Lauren Klingemann¹, Nigina Aripova², Amy Nelson¹, Jill Poole¹, Dawn Katafiasz¹, Kristina Bailey¹, Geoffrey Thiele¹ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²WUSTL, St. Louis, MO
Background/Purpose: Lung tissues from patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) have greater levels of malondialdehyde-acetaldehyde adducts (MAA) that co-localize with citrullinated (CIT) and…
Abstract Number: 0061 • ACR Convergence 2024
Comparative Transcriptional Profiling of IPF and RA-ILD Lung Tissue Demonstrates Both Overlapping and Distinct Cell-specific Signaling Pathways
Joshua Sciurba¹, Daniel Kass¹, Eleanor Valenzi², John Sembrat², Robert Lafyatis³ and Dana Ascherman⁴, ¹University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Transcriptional profiling represents a powerful tool for deciphering disease-relevant pathways and deriving functional biomarkers. Given the shared demographic, genetic, and clinico-epidemiologic features between rheumatoid…
Abstract Number: 0062 • ACR Convergence 2024
Pro-Fibrotic Effects of Malondialdehyde-Acetaldehyde-Adducted and/or Citrullinated Proteins on Macrophages and Human Lung Fibroblasts
Lauren Klingemann¹, Nozima Aripova¹, Nigina Aripova², Michael Duryee¹, Carlos Hunter¹, Jill Poole¹, Bryant England¹, Ted Mikuls¹ and Geoffrey Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²WUSTL, St. Louis, MO
Background/Purpose: Clinically evident rheumatoid arthritis-associated interstitial lung disease (RA-ILD) affects approximately 10-15% of patients with rheumatoid arthritis (RA) and accounts for the most overrepresented cause…
Abstract Number: 0771 • ACR Convergence 2024
Arid5b Controls Pathologic Inflammatory versus Invasive Fibroblast Behavior
Angela Zou¹, Suppawat Kongthong², Cassandra Murphy², Gerald Watts³, Alisa Mueller⁴ and Michael Brenner⁵, ¹Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Brookline, MA, ⁴Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Brigham and Women's Hospital, Harvard Medical School, Newton, MA
Background/Purpose: Synovial fibroblasts assume both inflammatory and tissue invasive roles in rheumatoid arthritis (RA). Recent studies have shown that these inflammatory and invasive functions are…
Abstract Number: 0969 • ACR Convergence 2024
Role and Mechanism of the Wnt3a-FZD5 Pathway in Regulating the Transformed Intermediate State of Alveolar Epithelial Cells Involved in Pulmonary Fibrosis in Systemic Sclerosis
Hang Yu¹ and Jing Xue², ¹zhejiang university, Hangzhou, China (People's Republic), ²The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)
Background/Purpose: Systemic sclerosis (SSc) is a diffuse connective tissue disease associated with multi-system and multi-organ tissue damage. The transformation of different precursor cells to myofibroblasts…
Abstract Number: 0972 • ACR Convergence 2024
Downregulated Fli1 in Scleroderma Myeloid Cells Contributes to Cardiac Fibrosis via a Galectin-3/mTOR Dependent Pathway
Fatima El adili¹, Moyo Mudhibadhi², Giovanni ligresti³, Maria Trojanowska² and Andreea Bujor³, ¹Boston Medical Center, Boston, MA, ²Boston university medical school, Boston, MA, ³Boston University, Boston, MA
Background/Purpose: Cardiac fibrosis is a common complication in Systemic sclerosis (SSc), but the pathogenesis is largely unknown. We have previously shown that monocytes isolated from…
Abstract Number: 1686 • ACR Convergence 2024
Urine Proteomics in Class II Lupus Nephritis Reveals Immune Activation and Pro-Fibrotic Signatures
Jasmine Shwetar¹, Jill Buyon², Michelle Petri³, Kelly Ruggles⁴ and Andrea Fava⁵, ¹New York School of Medicine, Ann Arbor, MI, ²NYU Grossman School of Medicine, New York, NY, ³Johns Hopkins University School of Medicine, Timonium, MD, ⁴NYU Grossman School of Medicine, Brooklyn, NY, ⁵Johns Hopkins University, Baltimore, MD
Background/Purpose: Lupus nephritis (LN) is a pathologically diverse autoimmune disease that can lead to end-stage kidney disease and mortality. Although Class II LN is considered…
Abstract Number: 1770 • ACR Convergence 2024
Assessing S100A4 and Myofibroblast Phenotypes in the Pathogenesis of Cardiac and Cutaneous Neonatal Lupus
Nalani Sachan¹, Christina Firl², Philip Carlucci³, Nicola Fraser², Robert Clancy⁴ and Jill Buyon⁵, ¹NYU Grossman School of Medicine, New York, NY, ²NYU Langone Health, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Columbia University Medical Center, New York, NY, ⁵New York University Grossman School of Medicine, New York, NY
Background/Purpose: Neonatal lupus (NL), driven by fetal exposure to maternal anti-SSA/Ro autoantibodies, typically results in permanent cardiac manifestations in utero and/or a transient rash postnatally.…

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