Abstracts tagged "Fibroblasts, Other"

Abstract Number: 1876 • ACR Convergence 2025
Targeting the NK cell checkpoint NKG2A promotes lung fibrosis resolution by enhancing immune clearance of senescent myofibroblasts
Wolfgang Merkt¹, Lea Rodon², Franca Sophie Deicher³, Maren Claus⁴, Rachel Lister⁵, Hongwei Han⁵, Yan Zhou⁵, Zhengwang Sun⁵, Arik Horne⁶, Ayla Nadja Stuetz⁷, Michael Kreuter⁸, nicolas kahn⁹, Marc Schneider⁹, Simon Haas¹⁰, Norbert Blank¹¹, Hanns-Martin Lorenz¹², Carsten Watzl⁴, Daniel Hübschmann¹³ and David Lagares⁵, ¹University Hospital Düsseldorf, Düsseldorf, Germany, ²University Hospital Heidelberg, Heidelberg, Hungary, ³Uniklinik Düsseldorf, Düsseldorf, Germany, ⁴IfADo, Leibniz Institute Dortmund, Dortmund, Germany, ⁵Massachusetts General Hospital and Harvard Medical School, Boston, ⁶Charite, Berlin, Berlin, ⁷Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Nordrhein-Westfalen, Germany, ⁸Universitätsmedizin Mainz, Mainz, ⁹Thoraxklinik, Heidelberg University, Heidelberg, Germany, ¹⁰Charite, Berlin, Berlin, Germany, ¹¹University Hospital Heidelberg, Heidelberg, Germany, ¹²Universitétsklinikum Heidelberg, Heidelberg, Germany, ¹³Heidelberg University, Berlin, Germany
Background/Purpose: A key event driving pulmonary fibrosis in interstitial lung disease (ILD) is the accumulation of pathologic senescent myofibroblasts, thought to be promoted by insufficient…
Abstract Number: 0808 • ACR Convergence 2025
Spatial Transcriptomics Show Fibroblast LIF Receptor Drives Fibrosis in Systemic Sclerosis
Mari Kamiya¹, Hung Nguyen¹, Miles Tran², Ce Gao³, Sergio Poli¹, Yunju Jeong⁴, Louis Merriam⁵, Jinjun Shi⁶, Rachel Knipe⁷, Katharine Black⁸, Lida Hariri⁹, Carol Feghali-Bostwick¹⁰, Rodney Infante¹¹, Janelle Pugashetti¹², Justin Oldham¹², Ilya Korsunsky¹³, Kevin Wei¹⁴ and Edy Kim¹, ¹Division of Pulmonary and Critical Care Medicine, Department of Medicine (DOM), Brigham and Women's Hospital (BWH); Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Inflammation and Immunity, DOM, BWH; Harvard Medical School, Boston, MA, ⁴Division of Pulmonary and Critical Care Medicine, Department of Medicine (DOM), Brigham and Women's Hospital (BWH), Harvard Medical School, Boston, MA, United States; Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul, Republic of Korea, ⁵Division of Pulmonary and Critical Care Medicine, Department of Medicine (DOM), Brigham and Women's Hospital (BWH), Boston, MA, ⁶Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (BWH); Harvard Medical School, Boston, MA, ⁷Division of Pulmonary and Critical Care Medicine, DOM, Massachusetts General Hospital; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital; Harvard Medical School, Boston, MA, ⁸Division of Pulmonary and Critical Care Medicine, DOM, Massachusetts General Hospital; Harvard Medical School, Boston, MA, ⁹Department of Pathology, Massachusetts General Hospital; Division of Pulmonary and Critical Care Medicine, DOM, Massachusetts General Hospital; Harvard Medical School, Boston, MA, ¹⁰Medical University of South Carolina, Charleston, SC, ¹¹Center for Human Nutrition, Dept. of Molecular Genetics, DOM, University of Texas Southwestern, Dallas, TX, ¹²Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, ¹³Division of Rheumatology, Inflammation and Immunity, DOM, BWH; Division of Genetics, DOM, BWH; Harvard Medical School, Boston, MA, ¹⁴Brigham and Women's Hospital at Harvard Medical School, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune, fibroinflammatory disease of skin and visceral organs. Current SSc therapies have limited efficacy for progressive fibrosis. Our prior…
Abstract Number: 1868 • ACR Convergence 2025
Global Downregulation of Fli1 in Mice Induces Cardiac Dysfunction via Enhanced β-fatty acid Oxidation and Collagen Deposition
Knowledge Mudhibadhi Moyo¹, Fatima-Ezzahrae El Adili², Maria Trojanowska¹ and Andreea Bujor¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Revere, MA
Background/Purpose: Primary cardiac involvement is a common complication of Systemic sclerosis (SSc), characterized by fibrosis and diastolic dysfunction, presumably due to microvascular dysfunction and repeated…
Abstract Number: 0102 • ACR Convergence 2025
Iron Metabolism Dysregulation and Inflammation in Ankylosing Spondylitis: Role of SLC39A14 in Extracellular Matrix Remodeling
Dachun Zhuo¹, Yulong Tang², Xiaobei Ma², Chengchun Geng¹, Jiangnan Xie¹, Jiucun Wang² and Jing Liu¹, ¹Fudan University, Shanghai, Shanghai, China (People's Republic), ²Fudan university, Shanghai, China (People's Republic)
Background/Purpose: Iron metabolism dysregulation has been increasingly recognized as a key factor in the pathogenesis of inflammatory arthritis, with evidence linking altered iron homeostasis to…
Abstract Number: 1866 • ACR Convergence 2025
Elucidating gastric pathology in systemic sclerosis using single-cell RNA sequencing
kristina clark¹, Moustafa Attar², Matthias Friedrich³, Charles Murray⁴, Alexander Clarke² and Christopher Denton⁵, ¹Kennedy Institute of Rheumatology, University of Oxford, London, United Kingdom, ²Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ³Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom, ⁴Royal Free Hospital NHS Trust, London, United Kingdom, ⁵University College London, UK, London, United Kingdom
Background/Purpose: Gastrointestinal (GI) involvement in systemic sclerosis (SSc) affects over 90% of patients and represents a large clinical burden and unmet need. Unlike the skin…
Abstract Number: 1863 • ACR Convergence 2025
Bag3 in systemic sclerosis: possible therapeutic target and biomarker for pulmonary fibrosis
Claudia Iannone¹, Margot De Marco², Antonina Minniti³, Giuseppe Armentaro⁴, Antonia Falco², Angela D'Ardia², paola Manzo², Liberato Marzullo⁵, Anna Basile², Alessandra Rosati², Maria Caterina Turco², Roberto Caporali⁶ and Nicoletta Del Papa⁷, ¹University of Milan, Gaetano Pini CTO, Milano, Milan, Italy, ²Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy, Baronissi, Campania, Italy, ³ASST Gaetano Pini, milano, Milan, Italy, ⁴ASST Pini-CTO, Clinical Rheumatology Unit, Milano, Italy, ⁵Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, Italy, Baronissi, Italy, ⁶University of Milan and ASST Gaetano Pini-CTO, Milano, Italy, ⁷ASST Pini CTO, Milano, Milan, Italy
Background/Purpose: BAG3 (Bcl2-associated athanogene 3) regulates cellular pathways including apoptosis and autophagy, and induces fibroblast-to-myofibroblast transformation. In systemic sclerosis (SSc), myofibroblasts drive fibrosis of skin…
Abstract Number: 1860 • ACR Convergence 2025
GLUT and FAPα as molecular imaging markers for interstitial lung disease in systemic sclerosis
Bo Broens¹, Conny van der Laken¹, Teodora Radonic¹, Douwe Mulder², esther Nossent¹, Yehya Al-Adwi², Tji Gan², Wim Timens², Alexandre Voskuijl³ and Jan Willem Duitman¹, ¹Amsterdam UMC, Amsterdam, Netherlands, ²UMCG Groningen, Groningen, Netherlands, ³Amsterdam University Medical Center, Amsterdam, Netherlands
Background/Purpose: The clinical management of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is challenging due to its heterogeneous progression. While recent studies have shown that pulmonary…
Abstract Number: 1856 • ACR Convergence 2025
Spatial Proteomic-based Phenotyping of Fibroblast Populations and their Microenvironment in Systemic Sclerosis Primary Heart Involvement
Ayla Nadja Stuetz¹, Giacomo de Luca², Alexandru-Emil Matei³, Yi-Nan Li⁴, Veronica Batani², Tim Filla⁵, Aleix Rius Rigau⁶, Bilgesu Safak Tümerdem¹, Cosimo Bruni⁷, Maike Büttner-Herold⁸, Stefania Rizzo⁹, Monica De Gaspari⁹, Markus Eckstein¹⁰, Georg Schett¹¹, Cristina Basso⁹, Jörg Distler¹², Marco Matucci-Cerinic¹³ and Andrea-Hermina Györfi¹⁴, ¹Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Nordrhein-Westfalen, Germany, ²Vita-Salute San Raffaele University. Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy, ³Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany, Düsseldorf, Germany, ⁴University Hospital of Düsseldorf, Düsseldorf, Germany, ⁵Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University., Düsseldorf, Germany, ⁶Department of Internal Medicine ³, Rheumatology and Clinical Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen. Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, ⁷Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁸Department of Nephropathology, University Hospital Erlangen, Erlangen, Germany, ⁹Cardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University and Hospital of Padua, Padua, Italy, ¹⁰Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ¹¹Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, ¹²University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ¹³University San Raffaele Milano, Milano, Milan, Italy, ¹⁴Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University., Düsseldorf, Germany
Background/Purpose: Primary heart involvement (pHI) is one of the leading causes of death in systemic sclerosis (SSc). However, the cellular and molecular pathomechanisms of SSc-pHI…
Abstract Number: 1830 • ACR Convergence 2025
Single-Cell and Spatial Profiling Reveal Proinflammatory and Profibrotic Fibroblast-Macrophage Niches in Lupus Nephritis
Chirag Raparia¹, Paul Hoover², Nir Hacohen³, Arnon Arazi⁴ and Anne Davidson¹, ¹Feinstein Institutes for Medical Research, Manhasset, NY, ²Brigham and Women's Hospital, Boston, MA, ³Broad Institute of MIT Harvard, Cambridge, MA, ⁴Feinstein Institutes for Medical Research, Acton, MA
Background/Purpose: Lupus nephritis (LN) is a severe complication of SLE that can progress to chronic kidney disease, renal fibrosis, and eventual renal failure. Fibroblasts activated…
Abstract Number: 1805 • ACR Convergence 2025
Human meniscus histopathological and transcriptomic changes at early and advanced stages of knee osteoarthritis
Takuya Sakamoto¹, Merissa Olmer¹, chelsea Kenvisay¹, Rachel Miller², Anne-Marie Malfait³, Darryl D'Lima⁴, William Bugbee⁵, Hannah Swahn⁶ and Martin Lotz⁷, ¹Scripps Research Institute, La Jolla, CA, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴Scripps Clinic, San Diego, CA, ⁵Scripps Clinic, La Jolla, CA, ⁶Scripps Research Institute, Carlsbad, CA, ⁷Scripps Research, La Jolla, CA
Background/Purpose: The knee menisci are essential in joint biomechanics while meniscus damage is a driver of knee osteoarthritis (OA) and an important source of knee…
Abstract Number: 1752 • ACR Convergence 2025
Prg4+ Ligament Cells Are Involved in Ligament Ossification in Ankylosing Spondylitis
Kunhai Tang¹, Lilu Zu¹, Chenyuan Wu¹, Jiucun Wang¹ and Jing Liu², ¹Fudan University, shanghai, China (People's Republic), ²Fudan University, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Ankylosing spondylitis(AS) is a chronic inflammatory disease with clinical symptoms characterized by inflammatory low back pain and spinal ankylosis due to ligament ossification. Enthesitis…
Abstract Number: 1684 • ACR Convergence 2025
Integration of Multiple Spatial Transcriptomics Reveals Novel Insights into Sjogren Disease Salivary Gland Fibroblast by Peripheral Serostatus
Zhou Fang¹, Ahmet Coskun¹ and Sara McCoy², ¹Georgia Tech, Atlanta, ²University of Wisconsin–Madison, Madison, WI
Background/Purpose: Anti-SSA antibody positive (SSA+ [Ro52 or Ro60]) and negative (SSA-) Sjögren disease (SjD) have differing clinical phenotypes and prognostic features; however, the pathogenesis driving…
Abstract Number: 1682 • ACR Convergence 2025
Sjögren’s Disease Salivary Gland Fibroblast Subsets are Proinflammatory and Aberrantly Promote Pain
Sara McCoy¹, Rachael Bogle², michele larsen³, Li Chen⁴, thomas pranzatelli⁵, Paola Perez⁶, john chiorini⁷, Alan Baer⁸, A. Darise Farris⁹, Christopher Lessard⁹, Astrid Rasmussen⁹, Caroline Shiboski¹⁰, Stephen Shiboski¹⁰, Alexander Mikesell³, Zachary Campbell³, Alex Tsoi², Johann Gudjonsson¹¹ and Blake M. Warner¹², ¹University of Wisconsin–Madison, Madison, WI, ²University of Michigan, Holland, OH, ³University of Wisconsin, Madison, ⁴University of Michigan, Ann Arbor, ⁵NIH, Bethesda, ⁶NIDCR, Bethesda, MD, ⁷NIH, bethesda, MD, ⁸Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰University of California San Francisco, San Francisco, CA, ¹¹University of Michigan, Ann Arbor, MI, ¹²National Institutes of Health, Bethesda, MD
Background/Purpose: Fibroblasts (fb) are increasingly recognized as dynamic signaling hubs in rheumatic disease, yet their contribution to Sjögren Disease (SjD) remains poorly defined. We dissect…
Abstract Number: 1560 • ACR Convergence 2025
Longitudinal assessment of circulating fibroblast activation protein in systemic sclerosis-associated interstitial lung disease
Bo Broens¹, Conny van der Laken¹, Iris Simons¹, Tamara Dekker¹, Jan Willem Duitman¹ and Alexandre Voskuijl², ¹Amsterdam UMC, Amsterdam, Netherlands, ²Amsterdam University Medical Center, Amsterdam, Netherlands
Background/Purpose: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is difficult to manage due to the heterogeneous disease course. There is a high need for biomarkers to…
Abstract Number: 0940 • ACR Convergence 2025
Resident Macrophages Localize Near Fibroblasts and Drive Reprogramming in Lupus Nephritis Through Direct and Soluble Signaling
Chirag Raparia¹, Paul Hoover², Arnon Arazi³, Nir Hacohen⁴ and Anne Davidson¹, ¹Feinstein Institutes for Medical Research, Manhasset, NY, ²Brigham and Women's Hospital, Boston, MA, ³Feinstein Institutes for Medical Research, Acton, MA, ⁴Broad Institute of MIT Harvard, Cambridge, MA
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of SLE that can progress to renal fibrosis, and eventual renal failure. In LN, tubulointerstitial inflammation and…

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