Abstracts tagged "fibroblasts and transforming growth factor"

Abstract Number: 1967 • 2014 ACR/ARHP Annual Meeting
Transforming Growth Factor Beta Is a Major Regulator of Micro-RNA Synthesis in Rheumatoid Arthritis Synovial Fibroblasts
Anna Engler¹, Emmanuel Karouzakis¹, Christoph Kolling², Renate E. Gay³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose Transforming growth factor beta (TGFβ) modulates microRNA (miRNA) biogenesis in a variety of cell types. The expression of miRNAs is deregulated in the synovial…
Abstract Number: 2572 • 2013 ACR/ARHP Annual Meeting
An Atypical Cyclin-Dependent Kinase Mediates Fibrosis and Is a Novel Target In Scleroderma
Jun Wei¹, Roberta G. Marangoni², Wenxia Wang³, Jingang Huang⁴, Joerg H. W. Distler⁴ and John Varga⁵, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Cyclin-dependent kinase 5 (CDK5), expressed primarily in the central nervous system, plays important roles in axonal guidance, dopaminergic signaling, neuronal migration, and pain sensing.…

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