ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "fibroblasts and systemic sclerosis"

  • Abstract Number: 120 • 2018 ACR/ARHP Annual Meeting

    An Orally Available Highly Selective 5-Hydroxytryptamine 2B Receptor Antagonist Ameliorating Pulmonary and Dermal Fibrosis in Preclinical Models of Systemic Sclerosis

    Christina Wenglén1, Helena Arozenius2, Lars Pettersson2 and Gunilla Ekström1, 1R&D, AnaMar AB, Lund, Sweden, 2AnaMar AB, Lund, Sweden

    Background/Purpose: Serotonin or 5-hydroxytryptamine (5-HT) is well known as a stimulator of tissue fibrosis and a significant role of peripheral 5-HT2B receptors in fibrosis has…
  • Abstract Number: 753 • 2017 ACR/ARHP Annual Meeting

    The Histone Demethylase Jumonji Domain-Containing Protein 3 (JMJD3) As Central Mediator of Fibroblast Activation

    Christina Bergmann1, Amelie Brandt1, Clara Dees2, Yun Zhang3, Chih-Wei Chen4, Tatjana Mallano5, Thomas Wohlfahrt6, Ruifang Liang7, Rosebeth Kagwiria1, Aline Bozec8, Ralf Rieker9, David Abraham10, Andreas Ramming11, Oliver Distler12, Georg Schett13 and Jörg Distler14, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 6Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 7Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 8Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, 9Department of Pathology, University Clinic Erlangen, Erlangen, Germany, 10Centre for Rheumatology and Connective Tissue, UCL School of Life and Medical Sciences, London, London, United Kingdom, 11Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 12Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 13Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 14Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany

    Background/Purpose: Epigenetic modifications are key drivers of chronic fibroblast activation. Trimethylation of histone 3 at lysine residue K27 (H3K27me3) is a repressive modification, that is…
  • Abstract Number: 762 • 2017 ACR/ARHP Annual Meeting

    M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts

    Atsushi Noguchi, Ilia Atanelishvili, Tanjina Akter, Richard M. Silver and Galina S. Bogatkevich, Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: We recently identified M10, a caspase cleavage product of the hepatocyte growth factor receptor, as an anti-fibrotic peptide that interacts with Smad2 and inhibits…
  • Abstract Number: 1716 • 2017 ACR/ARHP Annual Meeting

    TGFβ-Dependent Upregulation of XIAP Fosters Fibroblast Activation and Tissue Fibrosis By Promoting Canonical Wnt Signaling

    Christina Bergmann1, Ludwig Hallenberger1, Amelie Brandt1, Benita Merlevede1, Clara Dees2, Chih-Wei Chen3, Christian Beyer1, Oliver Distler4, Georg Schett5 and Jörg Distler6, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany

    Background/Purpose: Aberrant activation of profibrotic pathways is a key feature of systemic sclerosis (SSc). Extensive evidence characterizes TGFβ- and canonical WNT-signaling as key drivers of…
  • Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting

    Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells

    Tetsuo Toyama1, Yoshihide Asano1, Takehiro Takahashi1, Ryosuke Saigusa1, Yohei Ichimura1, Takashi Taniguchi1, Shinji Noda1, Kaname Akamata1, Shinichi Sato1, Takafumi Kadono1 and Koichi Shudo2, 1Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Reseach Foundation ITSUU Laboratory, Tokyo, Japan

    Background/Purpose:  Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…
  • Abstract Number: 2708 • 2013 ACR/ARHP Annual Meeting

    The Hedgehog Transcription Factor Gli-2 Is a Novel Downstream Mediator Of The Pro-Fibrotic Effects Of Transforming Growth Factor-Beta

    Barbora Sumova1,2, Cinzia Cordazzo3, Katrin Palumbo-Zerr4, Clara Dees4, Pawel Zerr4, Oliver Distler5, Georg Schett6, Ladislav Senolt7 and Joerg H. W. Distler4, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany, Erlangen, Germany, 2Department of Rheumatology of the First Faculty of Medicine, Institute of Rheumatology and Connective Tissue Research Laboratory, Prague, Czech Republic, 33Dipartimento Cardiotoracico e Vascolare, Laboratory of Respiratory Cell Biology, University of Pisa, Pisa, Italy, 4Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 7Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Systemic sclerosis (SSc) is characterized by aberrant activation of fibroblasts with increased release of extracellular matrix components. TGFβ is a key-mediator of fibroblast activation…
  • Abstract Number: 2709 • 2013 ACR/ARHP Annual Meeting

    Secreted Frizzled-Related Protein 4 Can Be Induced By Transforming Growth Factor-β, Is Regulated By Caveolin-1 and Can Induce Non-Canonical Wnt Signaling In Fibroblasts

    Justin Gillespie1, Giuseppina Abignano1, Michael McDermott1, Paul Emery1 and Francesco Del Galdo2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is a heterogeneous disease characterized by autoimmune activation, fibroproliferative vasculopathy, and tissue fibrosis of skin and multiple internal organs. Several studies…
  • Abstract Number: 2610 • 2013 ACR/ARHP Annual Meeting

    A New Pathogenic Role Of BAFF As a Critical Mediator Of Skin and Lung Fibrosis In Experimental Bleomycin-Induced Pulmonary Fibrosis, Systemic Sclerosis and Idiopathic Pulmonary Fibrosis

    Antoine Francois1, Pascal Schneider2, Anne Davidson3, Emmanuel Chatelus4, Jérôme Avouac5, Yannick Allanore6, Bérengère Villeret7, Aurélie Gombault7, Paméla Gasse8, Sylvain Marchand Adam9, Bernhard Ryffel10, Siamak Bahram11, Philippe Georgel12, Jean Sibilia13, Isabelle Couillin8 and Jacques-Eric Gottenberg14, 1Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, 2Department of Biochemistry, University of Lausanne, Lausanne, Switzerland, 3Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 4Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 6Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 7Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orléans, France, 8Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orleans, France, 9Francois Rabelais University, National institute of the health and the medical research, Tours, France, 10UMR6218, Molecular Immunology, University and CNRS, 3b rue de la Ferollerie, Orleans, France, 11Fédération of Translational Medicine of Strasbourg (FMTS), Immunorhumatology Molécular, Strasbourg, France, 12Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France, 13Rheumatology, CHU Hautepierre, Strasbourg, France, 14Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Interstitial pneumonitis and lung fibrosis are frequent systemic complications of inflammatory arthritides, including systemic sclerosis (SSc), rheumatoid arthritis, or primary Sjögren’s syndrome. B lymphocytes…
  • Abstract Number: 2559 • 2013 ACR/ARHP Annual Meeting

    Effect Of NOX4 Overexpression On The Levels Of Micro RNAs Relevant To Systemic Sclerosis Fibrotic Process

    Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

     Background/Purpose: Systemic sclerosis (SSc) is characterized by the excessive deposition of collagen and other connective tissue components in skin and multiple internal organs.  Although transforming…
  • Abstract Number: 2571 • 2013 ACR/ARHP Annual Meeting

    Pigment Epithelium Derived Factor Secreted By Activated Fibroblasts Can Contribute To Impaired Angio and Vasculogenesis In Scleroderma

    Vasiliki Liakouli1,2, Georgia Mavria3, Justin Gillespie4, Margherita Scarcia3, Paola Cipriani2, Roberto Giacomelli2, Paul Emery5 and Francesco Del Galdo5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, 2Rheumatology Unit, University of Aquila, L'Aquila, IT, L'Aquila, Italy, 3Signal Transduction and Angiogenesis group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK, Leeds, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterized by tissue fibrosis and vasculopathy. This latter comprises both neointima proliferation and defective angio and vasculogenesis.…
  • Abstract Number: 821 • 2013 ACR/ARHP Annual Meeting

    Activation Of The Signal Transducer and Activator Of Transcription 3 By Transforming Growth Factor-Beta Promotes Fibroblast Activation and Tissue Fibrosis

    Barbora Sumova1,2, Katrin Palumbo-Zerr3, Clara Dees3, Pawel Zerr3, Oliver Distler4, Georg Schett5, Ladislav Senolt6 and Joerg H. W. Distler3, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Germany, Erlangen, Germany, 2Department of Rheumatology of the First Faculty of Medicine, Institute of Rheumatology and Connective Tissue Research Laboratory, Prague, Czech Republic, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 6Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Systemic sclerosis (SSc) is characterized by uncontrolled activation of fibroblasts resulting in tissue fibrosis in which the TGFβ signaling plays a main role. Signal…
  • Abstract Number: 654 • 2013 ACR/ARHP Annual Meeting

    Effects Of Macitentan and Its Active Metabolite In Modulating Extracellular Matrix Synthesis In Cultured Human Systemic Sclerosis and Normal Skin Fibroblasts

    Maurizio Cutolo1, Paola Montagna2, Renata Brizzolara2, Elisa Alessandri3, Pietro Paolo Tavilla4, Aurora Parodi4, Alberto Sulli5 and Stefano Soldano6, 1University of Genova, Genova, Italy, 2Department of Internal Medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, 3Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 4Department of Endocrinologial and Medical Science, Unit of Dermatology, University of Genova, Genova, Italy, 5Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 6Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy

    Background/Purpose: Endothelin-1 (ET-1) has been shown to activate myofibroblasts and to enhance the synthesis of extracellular matrix proteins (ECM),  such as collagen type I (COL-1)…
  • Abstract Number: 2286 • 2012 ACR/ARHP Annual Meeting

    Dysregulated Discoidin Domain Receptor 2-Microrna 196a-Mediated Negative Feedback Against Excess Type I Collagen Expression in Scleroderma Dermal Fibroblasts

    Katsunari Makino1, Masatoshi Jinnin1, Jun Aoi1, Ikko Kajihara1, Takamitsu Makino2, Keisuke Sakai1, Satoshi Fukushima1, Yuji Inoue1 and Hironobu Ihn2, 1Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan, 2Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan

    Background/Purpose: Systemic sclerosis (SSc) is characterized by the excess deposition of collagen in the skin, due to intrinsic transforming growth factor (TGF)-β activation. The discoidin…
  • Abstract Number: 1717 • 2012 ACR/ARHP Annual Meeting

    Autologous Lipostructure in the Treatment of Fibrotic Perioral Changes in Systemic Sclerosis: A Pilot Study

    Nicoletta Del Papa1, Fabio Caviggioli2, Domenico Sambataro3, Eleonora Zaccara1, Gabriele Di Luca4, Valeriano Vinci2 and Marco Klinger5, 1UOC Day Hospital Reumatologia, G. Pini Hospital, Milano, Italy, 2UOC Chirurgia Plastica,, UOC Chirurgia Plastica, Multimedica Holding SpA, Università degli Studi di Milano, Milano, Italy, 3UOC Day Hospital Reumatologia,, G. Pini Hospital, Milano, Italy, 4UOS Chirurgia Vascolare,, Osp. G. Pini, Milano, Italy, 5UOC Chirurgia Plastica 2, Istituto Clinico Humanitas, Università degli Studi di Milano;, Milano, Italy

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by varying degree of fibrosis in skin and other tissues. Therapeutic options for fibrotic changes are very…
  • Abstract Number: 1522 • 2012 ACR/ARHP Annual Meeting

    Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis

    Jun Liang1, Tanjina Akter2, Ilia Atanelishvili3, Richard M. Silver4 and Galina S. Bogatkevich2, 1Department of Rheumatology, Medical University of SC, Charleston, SC, 2Department of Rheumatology, Medical University of South Carolina,Charleston,USA, Charleston, SC, 3Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, 4Rheumatology, Medical University of SC, Charleston, SC

    Background/Purpose: Interstitial lung disease is a prevalent and worrisome complication of systemic sclerosis (SSc), which is now the leading cause of death in SSc. There…
  • 1
  • 2
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology