Abstracts tagged "fibroblasts and synovial cells"

Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Yanying Liu², Aase Hensvold¹, Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström⁵, Khaled Amara¹, Johanna Steen¹, Muhammad Sohel Mia¹, Marianne Engström¹, Heidi Wähämaa¹, Jimmy Ytterberg¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…

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