Abstracts tagged "fibroblasts and scleroderma"

Abstract Number: 1705 • 2017 ACR/ARHP Annual Meeting
Inhibition of EZH2 Stops Fibrosis and Improves Angiogenesis in Scleroderma
Pei-Suen Tsou¹, Phillip L. Campbell², M. Asif Amin³, Patrick Coit¹, David Fox⁴, Dinesh Khanna⁵ and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ⁴Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease that involves activation of the immune system, vascular complications, and tissue fibrosis. Although the pathogenesis of this disease…
Abstract Number: 3003 • 2015 ACR/ARHP Annual Meeting
Increased Heparanase Expression in Keratinocytes Promotes Dermal Fibrosis in Scleroderma
In-Woon Baek¹, Wan-Uk Kim², Chul-Soo Cho¹ and Ki-Jo Kim³, ¹Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ²Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ³Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, South Korea
Background/Purpose: Interactions between keratinocyte and dermal fibroblast via paracrine loop play an important role in wound repair and keloid formation. In this study, we investigated…
Abstract Number: 657 • 2013 ACR/ARHP Annual Meeting
Lipoic Acid Plays a Crucial Role In Scleroderma Dermal Fibroblasts
Pei-Suen Tsou¹, Beatrix Balogh², Adam J. Pinney², George Zakhem², Ann Kendzicky², Elena Schiopu³, Dinesh Khanna⁴, David A. Fox⁵ and Alisa E. Koch^5,6, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶VA Medical Service, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived…
Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Swati Bhattacharyya¹, Zenshiro Tamaki², Wenxia Wang³, Paul Hoover⁴, Adam Booth⁵, Alyssa Dreffs⁶, Monique E. Hinchcliff⁷, Feng Fang⁸, Spiro Getsios⁴, Hang Yin⁹, Eric S. White⁶ and John Varga¹⁰, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Rheumatology, Northwestern Univ Med School, Chicago, IL, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Ann Arbor, MI, ⁶Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁷Division of Rheumatology, Northwestern Univ Med School, Chicago, IL, ⁸Rheumatology Division, Northwestern University, Chicago, IL, ⁹University of Colorado at Boulder, Boulder, CO, ¹⁰Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…
Abstract Number: 1520 • 2012 ACR/ARHP Annual Meeting
Role of 12/15-Lipoxygenase(LOX) in Patients with Systemic Sclerosis
Hirahito Endo, Makoto Kabraki, Koutarou Shikano, Sei Muraoka, Nahoko Tanaka, Tatsuhiro Yamamoto, Kanako Kitahara, Kaichi Kaneko, Yoshie Kusunoki, Natsuko Kusunoki, Kenji Takagi, Tomoko Hasunuma and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Recently 12/15-lipoxygenase (LOX) and it’s metabolites have a prominent anti-fibrotic role during dermal fibrosis in scleroderma experimental model using 12/15-LOX deficient mice were reported…
Abstract Number: 1498 • 2012 ACR/ARHP Annual Meeting
Wisp-1 Neutralization Reduces Gvhd-Induced Skin Fibrosis by Altering TSLP-OX40L Axis-Dependent Th2 Responses
Raphael Lemaire, Tim Burwell, Rachel Griffin, Julie Bakken, Joseph Madary, Lynne Murray, Ronald Herbst and Jane Connor, Research, MedImmune LLC, Gaithersburg, MD
Background/Purpose: There is accumulating evidence for a role of Wnt-signaling pathway activation in connective tissue disorders, including dermal and lung fibrosis. In particular, expression of…
Abstract Number: 1503 • 2012 ACR/ARHP Annual Meeting
Effect of Thiol Antioxidants On the Profibrotic Phenotype of Scleroderma Dermal Fibroblasts
Pei-Suen Tsou¹, Beatrix Balogh², Adam J. Pinney², Elena Schiopu³, Dinesh Khanna⁴ and Alisa E. Koch⁵, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (Scleroderma, SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in superoxide production and…

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