Abstracts tagged "fibroblasts and rheumatoid arthritis"

Abstract Number: 2002 • ACR/ARP Annual Meeting 2019
Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts
Samuel Finlay¹, Stefano Alivernini ², Aziza Elmesmari ³, Barbara Tolusso ², Luca Petricca ², Clara Di Mario ⁴, Annunziata Capacci ², Andrew Filer ⁵, Gianfranco Ferraccioli ², Iain McInnes ¹, Elisa Gremese ² and Mariola Kurowska-Stolarska ¹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, ⁴Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, ⁵Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
Abstract Number: 1959 • ACR/ARHP Annual Meeting 2018
Stability of DNA Methylation Signature in Primary RA Synovial Fibroblasts Compared with Cultured Fibroblast-like Synoviocytes
Rizi Ai¹, Deepa Hammaker², Wei Wang³ and Gary S. Firestein⁴, ¹University of California San Diego, La Jolla, CA, ²Medicine, UC San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, ⁴Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction. Fibroblast-like synoviocytes (FLS) play a key role in mediating…
Abstract Number: 865 • ACR/ARHP Annual Meeting 2017
Lasp-1 Regulates Cell-Matrix and Cell-Cell Contacts in Arthritic Mouse Models
Denise Beckmann¹, Annika Krause², Uwe Hansen¹, Hans Peter Kiener³, Thomas Kamradt⁴, Catherine S. Chew⁵, Thomas Pap² and Adelheid Korb-Pap¹, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute for Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Institute of Immunology, University Hospital Jena, Jena, Germany, ⁵Institute of Molecular Medicine and Genetics, Medical College of GA, GA, GA
Background/Purpose: In rheumatoid arthritis (RA) the attachment of synovial fibroblasts (SF) to articular cartilage is an important prerequisite in the process of cartilage degradation. The…
Abstract Number: 1163 • ACR/ARHP Annual Meeting 2015
Dynamic Regulation of Enhancers and Super-Enhancers in Rheumatoid Arthritis Synovial Finroblasts
Sung-Ho Park¹, Christopher Sohn¹, Konstantinos Loupasakis², Angela Lee³, Eugenia Giannopoulou¹, Lionel B. Ivashkiv³ and George D. Kalliolias¹, ¹Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ³Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Enhancers are regulatory elements that modulate transcriptional rates of genes. Super-enhancers (SupE) are extremely large enhancers associated primarily with highly expressed genes that have…