Abstracts tagged "fibroblasts and rheumatic disease"

Abstract Number: 3119 • 2016 ACR/ARHP Annual Meeting
Complete Whole Genome Transcriptome, DNA Methylation, and Histone Mark Analysis of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) Reveals a Distinctive Epigenetic Landscape and Critical Pathogenic Pathways
Rizi Ai¹, Deepa Hammaker², David L. Boyle³, Andre ‎ Wildberg⁴, Keisuke Maeshima², Emmanuele Palescandolo⁵, Vinod Krishna⁵, Bryan Linggi⁶, Radu Dobrin⁵, John W. Whitaker⁷, Wei Wang⁸ and Gary Firestein⁹, ¹Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ³Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁴Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁵Janssen Pharmaceuticals, Spring House, PA, ⁶janssen Pharmaceuticals, Spring House, PA, ⁷Janssen Pharmaceuticals, La Jolla, CA, ⁸Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁹Medicine, UCSD, La Jolla, CA
Background/Purpose: RA FLS display a unique aggressive phenotype with a distinctive DNA methylation profile that marks genes involved with cytokine signaling, cell recruitment, and matrix…

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