Abstracts tagged "Fc receptors and kinase"

Abstract Number: 2071 • ACR/ARHP Annual Meeting 2012
The Potent, Highly Selective and Orally Bioavailable Spleen Tyrosine Kinase Inhibitor GSK143 Demonstrates Efficacy in B Cell Receptor and Fc Receptor Signalling in Models of Inflammatory and Autoimmune Disease
Marion C. Dickson¹, Nicholas Smithers², Huw Lewis¹, Cesar Ramirez-Molina¹, Scott McCleary¹, Mike Barker¹ and John Liddle¹, ¹Immuno Inflammation, GSK, Stevenage, United Kingdom, ²Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: Spleen tyrosine kinase (Syk), a 72 KDa cytosolic non-receptor tyrosine kinase is a key mediator of B cell receptor (BCR) and Fc receptor (FcR)…