Abstracts tagged "family studies"

Abstract Number: 147 • 2020 Pediatric Rheumatology Symposium
Familial Clustering of Immune-mediated Diseases in Children with Abrupt-onset OCD
Avis Chan ¹, Tiffany Phu ¹, Bahare Farhadian ², Theresa Willett ³, Melissa Silverman ¹, Paula Tran ¹, Margo Thienemann ³ and Jennifer Frankovich⁴, ¹Stanford University School of Medicine, Palo Alto, ²Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ³Stanford University School of Medicine, Palo Alto, California, ⁴Stanford
Background/Purpose: Recent epidemiologic studies have reported increased rates of immune-mediated comorbidities among first-degree relatives of patients with OCD and tic disorders.(Mataix-Cols et al., Mol Psychiatry…
Abstract Number: 117 • 2020 Pediatric Rheumatology Symposium
Family Impact of Juvenile Localized Scleroderma
Katia Milovanova¹, Vimal Prajapati ², Merna Adly ², Rebeka Stevenson ³, Brendan Lethebe ² and Nadia Luca ², ¹University of Alberta, Edmonton, Alberta, Canada, ²University of Calgary, Calgary, Alberta, Canada, ³Cochrane, Alberta, Canada
Background/Purpose: Juvenile localized scleroderma (jLS) is a rare autoimmune disease that can lead to significant morbidity. Previous studies have focused on predictors of patient health-related…
Abstract Number: 1104 • 2019 ACR/ARP Annual Meeting
Heritability and Familial Risk of Systemic Lupus Erythematosus in Sweden: A Population-based Case-control Study
Elizabeth Arkema¹, Marios Rossides ¹, Christopher Sjöwall ², Elisabet Svenungsson ³ and Julia Simard ⁴, ¹Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Previous studies examining the relative risk (RR) associated with having a first degree relative (FDR) with systemic lupus erythematosus (SLE) were small and few…
Abstract Number: 2186 • 2018 ACR/ARHP Annual Meeting
Process Evaluation of a Culturally-Sensitive, Community Based Self-Management Program for First Nations People with Arthritis and Their Families
Diane Lacaille¹, June Kaminski², Jade Collison³, Linda Lavender⁴, Monica Brown⁵, Kim Roberts⁶, Deborah Da Costa⁷, Paul Adam⁸, Linda Li² and Allen Lehman⁹, ¹Arthritis Research Canada/University of British Columbia, Medicine/Rheumatology, Richmond, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Haida Health Centre, Old Massett, BC, Canada, ⁴Kwakiutl District Council Health Services, Campbell River, BC, Canada, ⁵Director, Haida Health Centre, Old Massett, BC, Canada, ⁶Director, Kwakiutl District Council Health Services, Campbell River, BC, Canada, ⁷Medicine, McGill University, Montreal, QC, Canada, ⁸Mary Pack Arthritis Program, Vancouver, BC, Canada, ⁹Senior Medical Scientific Liaison-Rheumatology, Janssen, Pharmaceutical Companies of Johnson and Johnson, Vancouver, BC, Canada
Background/Purpose: First Nation community consultations identified arthritis as a priority health concern and the need for culturally sensitive health services adapted to community needs. In…
Abstract Number: 1308 • 2017 ACR/ARHP Annual Meeting
Answering Reproductive Health Questions That Your Patients Want to Know: Impediments to Family Building and Risks of Contraception
Malithi Jayasundara¹, Amanda M. Eudy², Tayseer Haroun³, W. Benjamin Nowell⁴, Jeffrey R. Curtis⁵, Rachelle Crow-Hercher⁶, Charlotte Whitney White⁶, Seth D. Ginsberg⁷ and Megan E. B. Clowse⁸, ¹Rheumatology, Duke University, Durham, NC, ²Duke University, Durham, NC, ³Department of Medicine/Division of Rheumatology, Duke University Medical Center, Durham, NC, ⁴Global Healthy Living Foundation, Upper Nyack, NY, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Arthritis Power, Upper Nyack, NY, ⁷Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ⁸Duke University Medical Center, Durham, NC
Background/Purpose: Women with arthritis wonder whether they will be able to have the children they desire. They also worry that oral contraceptives may worsen their…
Abstract Number: 1364 • 2017 ACR/ARHP Annual Meeting
Incidence of Rheumatoid Arthritis in a Cohort of First Degree Relatives from the Studies of the Etiology of Rheumatoid Arthritis
Diraj R. Karnani¹, Lindsy J. Forbess², Michael Weisman³, Kevin D. Deane⁴, V. Michael Holers⁵ and Jill M. Norris⁶, ¹Department of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, ²Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁵Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁶Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: First-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) are at increased risk for developing RA compared to the general population. The purpose of…
Abstract Number: 1505 • 2017 ACR/ARHP Annual Meeting
Gender Bias in the Inheritance of Ankylosing Spondylitis
Karim Doughem¹, Michael Weisman², Lianne S. Gensler³, Mohammad H. Rahbar⁴, MinJae Lee⁴, Laura A. Diekman⁵, Matt Brown⁶, Michael Ward⁷ and John D. Reveille⁵, ¹Rheumatology, The University of Texas-McGovern Medical School, Houston, TX, ²Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, ³Medicine/Rheumatology, UCSF, San Francisco, CA, ⁴Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁵Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ⁶Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁷NIH/NIAMS, Bethesda, MD
Background/Purpose: There are few studies of the heritability of ankylosing spondylitis (AS) in families, a disease where hereditary factors play a dominant role in disease…
Abstract Number: 985 • 2016 ACR/ARHP Annual Meeting
Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool with or without a Health Educator for Knowledge of RA Risk Factors
Maria G. Prado¹, Rachel Miller Kroouze¹, Zhi Yu¹, Maura D. Iversen^2,3,4, Nellie A. Triedman¹, Sarah S. Kalia⁵, Kevin D. Deane⁶, Karen H. Costenbader¹, Bing Lu¹, Robert C. Green⁵, Elizabeth W. Karlson¹ and Jeffrey A. Sparks⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden, ³Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Much progress has been made in identifying risk factors for RA, but it is unclear whether individuals at risk for RA have knowledge of…
Abstract Number: 991 • 2016 ACR/ARHP Annual Meeting
Familial Aggregation of Rheumatoid Arthritis in Sarcoidosis: A Register-Based Case-Control Study in Sweden
Elizabeth V. Arkema, Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Sarcoidosis is an inflammatory disease with unknown etiology that primarily affects the lungs and lymph glands. Sarcoidosis shares some features with rheumatoid arthritis (RA),…
Abstract Number: 1022 • 2015 ACR/ARHP Annual Meeting
Identification of Shared Genomic Regions in Distantly Related Pairs of Cases with Juvenile Idiopathic Arthritis
Sampath Prahalad¹, K. Alaine Broadaway², John F. Bohnsack³, Ann Dodd², Aimee O. Hersh⁴, Sheila T. Angeles-Han¹, Se Ryeong Jang¹, Marc Sudman⁵, Susan D. Thompson⁶, Michael Zwick⁷, Karen Conneely² and Michael Epstein², ¹Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, ⁴Pediatrics/Rheumatology, University of Utah, Salt Lake City, UT, ⁵Divison of Rheumatology, Childrens Hospital Med Ctr, Cincinnati, OH, ⁶Rheumatology Dept, Childrens Hospital Med Ctr, Cincinnati, OH, ⁷Human Genetics, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a complex genetic trait. While several risk variants have been identified using genome wide studies, a substantial component of…
Abstract Number: 1069 • 2015 ACR/ARHP Annual Meeting
Child’s HLA-DRB1 Genotype Increases Maternal Risk of Systemic Lupus Erythematosus: Results from the Mother-Child Immunogenetic Study in Autoimmunity
Giovanna I. Cruz¹, Xiaorong Shao², Hong L. Quach², Janelle Noble³, Nikolaos Patsopoulos⁴, Michael Busch⁵, Darrell Triulzi⁶, Wendy S.W. Wong⁷, Benjamin Solomon⁷, John Niederhuber⁷, Lindsey A. Criswell⁸ and Lisa F. Barcellos², ¹School of Public Health, University of California, Berkeley, Berkeley, CA, ²Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ³Children's Hospital Oakland Research Institute, Oakland, CA, ⁴Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁵Blood Systems Research Institute, San Francisco, CA, ⁶Institute of Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Medical Genomics, Inova Translational Medicine Institute, Falls Church, VA, ⁸Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: SLE [MIM 152700] disproportionately affects women of reproductive age and pregnant patients are more likely to experience flares. Fetal microchimerism (FMC), or the persistence…
Abstract Number: 2101 • 2015 ACR/ARHP Annual Meeting
HLA Associations in Mothers of Children with Cardiac Manifestations of Neonatal Lupus
Hannah C. Ainsworth¹, Carl D. Langefeld¹, Miranda C. Marion², Nathalie Costedoat-Chalumeau³, Antonio Brucato⁴, Jill P. Buyon⁵ and Robert M. Clancy⁵, ¹Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, ³Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁴Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁵Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Cardiac manifestations of neonatal lupus, comprising atrioventricular conduction defects and cardiomyopathy, occur in fetuses exposed to anti-Ro/SSA antibodies, and carry substantial mortality. There is…
Abstract Number: 2890 • 2014 ACR/ARHP Annual Meeting
Does a Family History of RA Influence the Clinical Presentation and Treatment Response in RA?
Thomas Frisell¹, Saedis Saevarsdottir^2,3 and Johan Askling^1,4, ¹Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Since family history of RA is among the strongest risk factors for developing the disease, individuals suspected to have RA are routinely asked about…
Abstract Number: 1403 • 2014 ACR/ARHP Annual Meeting
Psychosocial Impact of Rheumatoid Arthritis Patients on Their Family Members
Sang Wan Chung¹, Ji Ae Yang², Eun Ha Kang¹, Yun Jong Lee^1,3 and You Jung Ha¹, ¹Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ³Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory arthritis that can cause pain and functional disability, and RA patients have a higher risk of psychiatric…
Abstract Number: 1767 • 2013 ACR/ARHP Annual Meeting
Gender, Race, and Soluble Mediators Distinguish Blood Relatives Who Develop Incomplete Lupus Or Classified SLE In The Lupus Autoimmunity In Relatives (LAUREL) Study
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris², Joel M. Guthridge³, Diane L. Kamen⁴, Timothy B. Niewold⁵, Gary S. Gilkeson⁴, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J. Wallace⁷, David R. Karp⁸, John B. Harley^9,10 and Judith A. James^11,12, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁹Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁰US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and identify individuals for prevention trials. Healthy blood relatives (FDRs) of lupus…

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