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Abstracts tagged "Familial Mediterranean fever"

  • Abstract Number: 195 • 2015 ACR/ARHP Annual Meeting

    Activation of the Pyrin Inflammasome through the RhoA Signaling Pathway in Familial Mediterranean Fever (FMF) and Hyperimmunoglobulinemia D Syndrome (HIDS)

    Yong Hwan Park, Geryl Wood, Daniel Kastner and Jae Jin Chae, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, NIH/NHGRI, Bethesda, MD

    Background/Purpose: Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause the autoinflammatory diseases familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS), respectively. …
  • Abstract Number: 246 • 2015 ACR/ARHP Annual Meeting

    Adult Autoinflammatory Disease Frequency and Our Diagnostic Experience in an Adult Autoinflammatory Clinic

    Qingping Yao1, Felicitas Lacbawan2 and Jianbo Li1, 1Cleveland Clinic, Cleveland, OH, 2Molecular Genetics Pathology, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Autoinflammatory diseases (AIDs), aka, periodic fever syndromes include monogenic diseases, such as familial Mediterranean fever (FMF), cryopyrin-associated periodic disease (CAPS), tumor necrosis factor receptor-associated…
  • Abstract Number: 941 • 2015 ACR/ARHP Annual Meeting

    Relationship Between Colchine Plasma Level and Frequency of Familial Mediterranean Fever Attacks

    Fadime Canbolat1, Gulsen Ozen2, Selma Ozilhan1, Samet Gulturk3, Ayse Ozcetin4, Ali Ugur Unal2, Nevsun Inanc2, Pamir Atagunduz2, Haner Direskeneli2 and Tuncel Ozden1, 1Department of Pharmacology, Uskudar University Pharmacogenetic Laboratory, Istanbul, Turkey, 2Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Molecular Biology and Genetics, Uskudar University, Istanbul, Turkey, 4Department of Neuroscience, Uskudar University, Istanbul, Turkey

    Background/Purpose: Colchicine is the mainstay of Familial Mediterranean Fever (FMF) treatment that reduces the frequency of attacks and prevents amyloidosis in the majority of patients. Colchicine,…
  • Abstract Number: 2270 • 2014 ACR/ARHP Annual Meeting

    Changes in Cerebral Blood Flow Velocity in Patients with Familial Mediterranean Fever

    Gozde Yildirim Cetin1, Uygar Utku2, Nurhan Atilla3, Kadir Gisi4 and Mehmet Sayarlioglu5, 1Deparment of Rheumatology, Sutcu Imam University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey, 2Neurology, Kahramanmaras Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey, 3Chest Diseases, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey, 4Gastroenterology, Sutcu Imam University, School of Medicine, Kahramanmaras, Turkey, 5Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey

    Background/Purpose Familial Mediterranean fever (FMF) is a hereditary and an auto-inflammatory disease predominantly characterized by repeated attacks of fever, abdominal pain, pleuritic chest pain, arthritis…
  • Abstract Number: 1229 • 2014 ACR/ARHP Annual Meeting

    Is NOD2-Associated Autoinflammatory Disease Remotely Related to Familial Mediterranean Fever or Continuum of It?

    Min Shen1, Bo Shen2 and Qingping Yao3, 1Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, 2Gastroenterology, Cleveland Clinic, Cleveland, OH, 3Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose NOD2-associated autoinflammatory disease (NAID) is a newly described autoinflammatory disease characterized by periodic fever, dermatitis, polyarthritis, gastrointestinal and sicca symptoms. It is genotypically associated…
  • Abstract Number: 1858 • 2013 ACR/ARHP Annual Meeting

    Investigating The Role Of IL-22 In The Pathogenesis Of Familial Mediterranean FEVER

    Dilek Keskin1, Goksal Keskin2, Ali Inal3 and Lale Ozisik4, 1Immunology, DYB Research and Training Hospital, Ankara, Turkey, 2Internal Medicine and Clinical Immunology, DYB Research and Training Hospital, Ankara, Turkey, 3GATA, Immunology, MD, Ankara, Turkey, 4Internal Medicine, MD, Ankara, Turkey

    Background/Purpose: Familial mediterranean fever (FMF) is a familial disease characterized by recurrent episodes of febrile serositis, peritonitis, arthritis andpleuritis. Many studies have been performed as an attempt to understand…
  • Abstract Number: 1209 • 2013 ACR/ARHP Annual Meeting

    Starting Time Of Inflammatory Attacks In Patients With Familial Mediterranean Fever

    Feyza Berktas1, Nilufer Alpay Kanitez1, Bahtiyar Toz1, Oguz Kaan Bakkaloglu1, Burak Erer2 and Ahmet Gul1, 1Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Department of Internal Medicine, Rheumatology Division, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Background/Purpose: Familial Mediterranean fever (FMF), the most common form of the hereditary autoinflammatory diseases, is characterized by recurrent self-limiting attacks of fever and/or serositis accompanied…
  • Abstract Number: 1211 • 2013 ACR/ARHP Annual Meeting

    Adult Autoinflammatory Phenotypes Associated With Heterozygous MEFV Mutations: A Continuum of Familial Mediterranean Fever?

    Qingping Yao, Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Familial Mediterranean fever (FMF) is traditionally regarded as an autosomal recessive disease characterized by periodic fever, serositis, erysipelas-like erythema and good response to colchicine. The…
  • Abstract Number: 1212 • 2013 ACR/ARHP Annual Meeting

    Are Different Disease Subtypes With Distinct Clinical Expression Present In Familial Mediterranean Fever: Results Of a Cluster Analysis

    Servet Akar1, Timucin Kasifoglu2, Dilek Solmaz1, Sule Yasar Bilge2, Ismail Sari1 and Mehmet Tunca3, 1Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, 2Rheumatology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey, 3Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey

    Background/Purpose: Familial Mediterranean fever (FMF) is an auto-inflammatory disorder characterized by self limited attacks of fever and serositis. The disease expression may be different in…
  • Abstract Number: 750 • 2012 ACR/ARHP Annual Meeting

    Efficacy and Safety of Canakinumab in Adults with Colchicine Resistant Familial Mediterranean Fever

    A. Gul1, H. Ozdogan2, B. Erer3, S. Ugurlu2, Nicole Davis4, S. Sevgi5 and O. Kasapcopur6, 1Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey, 3Istanbul Faculty of Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 4Novartis Pharma Corp, East Hannover, 5Novartis Pharma, Istanbul, Turkey, 6Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

    Background/Purpose: Familial Mediterranean fever (FMF) is associated with variations in the MEFV gene resulting in proteolytic activation of IL-1β through the inflammasome complex. FMF is…
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