Abstracts tagged "extracellular matrix proteins and osteoarthritis"

Abstract Number: 2123 • 2016 ACR/ARHP Annual Meeting
Follistatin-like Protein 1 Is a Potent Regulator of Articular Chondrocytes in Osteoarthritis
Yury Chaly, Bruce Hostager, Sonja Smith and Raphael Hirsch, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Osteoarthritis (OA) is the most common degenerative disease of the joints, affecting nearly 30 million Americans. It is characterized by a change in chondrocyte…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 10 • 2012 ACR/ARHP Annual Meeting
Fibronectin Fragment Induces Procatabolic Effects Through TLR-2 Signaling Pathway in Human Articular Chondrocytes
Su Jin Park¹, Eun-Jeong Cheon² and Hyun Ah Kim³, ¹Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ²Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea
Background/Purpose: Fibronectin fragments (FN-fs) are increased in the synovial fluid of osteoarthritis patients and have a potent chondrolytic effect. However, little is known about the…

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