ACR Meeting Abstracts

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Abstracts tagged "Etiopathogenesis"

  • Abstract Number: 380 • 2019 ACR/ARP Annual Meeting

    Seasonal Clustering of Acute Sarcoidosis in South-West Germany and Associations with Particulate Matter Air Pollution

    Philipp Rustler1, Dirk Schindler 2, Reinhard Voll 1 and Florian Kollert 3, 1Division of Rheumatology and Clinical Immunology, Medical Centre - University of Freiburg, Freiburg, Germany, 2Environmental Meteorology, University of Freiburg, Freiburg, Germany, 3Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital Bern, Bern, Switzerland

    Background/Purpose: Sarcoidosis is a multisystemic granulomatous disorder of unknown origin. The central role of macrophages and granuloma formation, the predominant involvement of lung and skin,…
  • Abstract Number: 1894 • 2018 ACR/ARHP Annual Meeting

    Baricitinib-Associated Changes in Type l Interferon Gene Signature during a 24-Week Phase-2 Clinical SLE Trial

    Thomas Dörner1, Yoshiya Tanaka2, Michelle Petri3, Josef S. Smolen4, Ernst R. Dow5, Richard E. Higgs5, Robert J. Benschop5, Adam Abel5, Maria E. Silk5, Stephanie de Bono5 and Robert W. Hoffman5, 1Charité Universitätsmedizin Berlin and Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 5Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: In the phase 2 study JAHH (NCT02708095), treatment with baricitinib (bari), an oral selective Janus kinase 1/2 inhibitor approved for the treatment of RA,…
  • Abstract Number: 2825 • 2017 ACR/ARHP Annual Meeting

    A Possible Environmental Origin for a Proportion of the Genetic Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    John B. Harley1, Xiaoting Chen1, Mario Pujato2, Daniel Miller1, Avery Maddox1, Carmy Forney3, Albert Magnusen3, Arthur Lynch1, Kashish Chetal4, Masashi Yukawa5, Artem Barski6, Nathan Salomonis4, Kenneth Kaufman7, Leah C. Kottyan8 and Matthew Weirauch9, 1Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Divisions of Allergy and Immunology and Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Divisions of Allergy and Immunology and Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 8Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Nearly 150 genetic loci are convincingly associated with lupus (SLE) or rheumatoid arthritis (RA) and underlie their incompletely understood mechanisms of pathogenesis. Since 90%…
  • Abstract Number: 262 • 2016 ACR/ARHP Annual Meeting

    Seasonal Variation in Incidence of Sarcoidosis: A Population-Based Study 1976-2013

    Patompong Ungprasert1, Cynthia S. Crowson2 and Eric L. Matteson1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN

    Seasonal Variation in Incidence of Sarcoidosis: A Population-Based Study 1976-2013 Background/Purpose:   Sarcoidosis is a multi-systemic disorder of unknown etiology. Studies of seasonal and regional…
  • Abstract Number: 520 • 2015 ACR/ARHP Annual Meeting

    Antibody to Porphyromonas Gingivalis in Pre-Clinical Rheumatoid Arthritis

    Brian Coburn1, Kevin D. Deane2, Jess D. Edison3, Geoffrey M. Thiele1, Michael J. Duryee4, Carlos D. Hunter4, Jeffrey Payne5, Fang Yu6, Harlan Sayles6, V. Michael Holers2, Jill M. Norris7, William R Gilliland8, Jeremy Sokolove9, WH Robinson9 and Ted R. Mikuls1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Walter Reed National Military Medical Center, Bethesda, MD, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 6University of Nebraska Medical Center, Omaha, NE, 7Epidemiology, University of Colorado Denver, Aurora, CO, 8Rheumatology Service, Walter Reed National Military Medical Center, Bethesda, MD, 9VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA

    Background/Purpose: Periodontitis (PD) has been implicated as an etiologic risk factor in rheumatoid arthritis (RA), an association that is speculated to be related to the…
  • Abstract Number: 1645 • 2014 ACR/ARHP Annual Meeting

    Interferon Gene Signature Expression and Serological Differences in Japanese and Non-Japanese SLE Patients

    Hitoshi Kohsaka1, Kosuke Kotani2, Tomonori Ishii3, Tomoya Miyamura4, Masato Okada5, Toshihiko Aranishi2, R. Maciuca6, William P. Kennedy6 and Junko Ohata2, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences,, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Chugai Pharmaceutical co., ltd, Tokyo, Japan, 3Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 4Department of Internal Medicine and Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, 5Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 6Genentech, Inc, South San Francisco, CA

    Background/Purpose: Elevated expression of interferon(IFN)-regulated genes in peripheral blood cells has been reported in systemic lupus erythematosus (SLE) patients and is known as the IFN…
  • Abstract Number: 929 • 2014 ACR/ARHP Annual Meeting

    Antibiotic Exposure and the Development of Juvenile Idiopathic Arthritis: A Population-Based Case-Control Study

    Daniel B. Horton1,2, Frank I. Scott IV1,3, Kevin Haynes1, Mary E. Putt1, Carlos D. Rose2, James D. Lewis1,3 and Brian L. Strom1,4, 1Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Pediatrics, Division of Rheumatology, Nemours A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, 3Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, 4Rutgers Biomedical and Health Sciences, Newark, NJ

    Background/Purpose: Dysregulation of the human microbiome has been implicated in the development of several autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). Moreover,…
  • Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting

    Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis

    Sebastien Viatte1, Paul Martin2, Andrew Brass3, Mark Lunt4, Anne Barton5 and Stephen Eyre5, 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 3School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, 4Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, 5Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
  • Abstract Number: 2405 • 2013 ACR/ARHP Annual Meeting

    Respiratory Diseases As Risk Factors For Rheumatoid Arthritis

    Marie Holmqvist1, Johan Askling1, Lars Alfredsson2, Camilla Bengtsson2, Fredrik Nyberg3 and Göran Tornling4, 1Karolinska Institutet, Stockholm, Sweden, 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 3AstraZeneca R&D, Mölndal, Sweden, 4Respiratory Medicine Unit, Department of Medicine Solna and CMM, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is only partly understood. In addition to smoking, other airway exposures, e.g. silica dust and traffic pollution, have…
  • Abstract Number: 2039 • 2013 ACR/ARHP Annual Meeting

    Micro and Nanoparticles As Possible Causative-Prognostic Co-Factors Of Mixed Cryoglobulinemia Syndrome

    Erica Artoni1, Gian Luca Sighinolfi1, Daniele Campioli2, Marco Sebastiani3, Dilia Giuggioli3 and Clodoveo Ferri4, 1Life Sciences, University of Modena and Reggio Emilia, Modena, Italy, 2Laboratory of Clinical Chemistry, Azienda Ospedaliera - Policlino di Modena, Modena, Italy, 3Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, 4Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy

    Background/Purpose:  We previously demonstrated that patients affected by membranoproliferative glomerulonephritis and mixed cryoglobulinemia syndrome (MCs) show the presence of circulating micro and nanoparticles (MPs and…
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