Abstracts tagged "Erythropoiesis"

Abstract Number: 1431 • ACR Convergence 2021
Human TLR8 Leads to Fatal Anemia Due to Ineffective Erythropoiesis in Bone Marrow Erythroblastic Islands in Murine SLE
Naomi Maria¹, Julien Papoin¹, Chirag Raparia¹, Zeguo Sun², Shani Martinez¹, Weijia Zhang², Lionel Blanc¹ and Anne Davidson¹, ¹Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY, ²Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: There are multiple causes of anemia in SLE including hemolysis, inflammation, renal insufficiency and, more rarely, microangiopathy, hemophagocytosis and bone marrow insufficiency. One cause…